Search Results - "Adam, Gregory C."

Novel Pan-Coronavirus 3CL Protease Inhibitor MK-7845: Biological and Pharmacological Profiling.

Authors: Alvarez, Nadine Adam, Gregory C. Howe, John A. et al.

Source: Viruses (1999-4915). Jul2024, Vol. 16 Issue 7, p1158. 22p.

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Efficacy evaluation of the S-adenosylhomocysteine hydrolase inhibitor MSD-914 in rhesus macaques (Macaca Mulatta) challenged with Ebola virus by the intramuscular route.

Authors: Johnston, Sara C. Ginnetti, Anthony T. Twenhafel, Nancy A. et al.

Source: PLoS ONE. 2/6/2026, Vol. 21 Issue 2, p1-22. 22p.

Activity-Based Protein Profiling in Vivo Using a Copper(I)-Catalyzed Azide-Alkyne {3 + 2} Cycloaddition.

Authors: Speers, Anna E. Adam, Gregory C. Cravatt, Benjamin F.

Source: Journal of the American Chemical Society; April 23 2003, Vol. 125 Issue 16, p4686-4687, 2p

Application of Affinity Selection/Mass Spectrometry to Determine the Structural Isomer of Parnafungins Responsible for Binding Polyadenosine Polymerase.

Authors: Adam, Gregory C. Parish, Craig A. Wisniewski, Douglas et al.

Source: Journal of the American Chemical Society. 12/10/2008, Vol. 130 Issue 49, p16704-16710. 7p. 6 Graphs.

Subjects: Candida albicans, Spectrum analysis, Natural products, Stereoisomers, Pathogenic fungi, Antifungal agents

Mapping Enzyme Active Sites in Complex Proteomes.

Authors: Adam, Gregory C. Burbaum, Jonathan Kozarich, John W. et al.

Source: Journal of the American Chemical Society. 2/11/2004, Vol. 126 Issue 5, p1363-1368. 6p.

Subjects: Genomes, Enzymes, Aldehyde dehydrogenase, Prokaryotes, Glutathione, Gel electrophoresis, Isotopes

Elucidation of DnaE as the Antibacterial Target of the Natural Product, Nargenicin.

Authors: Painter, Ronald E. Adam, Gregory C. Arocho, Marta et al.

Source: Chemistry & Biology. Oct2015, Vol. 22 Issue 10, p1362-1373. 12p.

Affinity-based ranking of ligands for DPP-4 from mixtures

Authors: Adam, Gregory C. Meng, Juncai Athanasopoulos, John et al.

Source: Bioorganic & Medicinal Chemistry Letters. May2007, Vol. 17 Issue 9, p2404-2407. 4p.

Discovery of arylsulfonamides as a novel class of allosteric integrase inhibitors with antiviral activity.

Authors: Wang, Cheng Adam, Gregory C. Burlein, Christine et al.

Source: Bioorganic & Medicinal Chemistry Letters. Jun2023, Vol. 89, pN.PAG-N.PAG. 1p.

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.

Authors: Petrilli, Whitney L. Adam, Gregory C. Erdmann, Roman S. et al.

Source: Cell Chemical Biology. Jan2020, Vol. 27 Issue 1, p32-32. 1p.

A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.

Authors: Cosden, Mali Jinn, Sarah Yao, Lihang et al.

Source: Neurobiology of Disease. Nov2021, Vol. 159, pN.PAG-N.PAG. 1p.

Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease.

Authors: Mudhasani RR Golden JW Adam GC et al.

Source: Microbiology spectrum [Microbiol Spectr] 2024 Apr 02; Vol. 12 (4), pp. e0358623. Date of Electronic Publication: 2024 Feb 23.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural

Journal Info: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE

Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.

Authors: Shurtleff VW Layton ME Parish CA et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 3935-3958. Date of Electronic Publication: 2024 Feb 16.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections.

Authors: Loughran HM Schirripa KM Roecker AJ et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Dec 21; Vol. 15 (1), pp. 123-131. Date of Electronic Publication: 2023 Dec 21 (Print Publication: 2024).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.

Authors: Roecker AJ Schirripa KM Loughran HM et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Jan 12; Vol. 14 (2), pp. 146-155. Date of Electronic Publication: 2023 Jan 12 (Print Publication: 2023).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.

Authors: Moore KP Schwaid AG Tudor M et al.

Source: ACS chemical biology [ACS Chem Biol] 2022 Sep 16; Vol. 17 (9), pp. 2595-2604. Date of Electronic Publication: 2022 Aug 31.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Discovery of the First Non-cGMP Mimetic Small Molecule Activators of cGMP-Dependent Protein Kinase 1 α (PKG1α).

Authors: Hanisak J Soriano A Adam GC et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Jul 16; Vol. 12 (8), pp. 1275-1282. Date of Electronic Publication: 2021 Jul 16 (Print Publication: 2021).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Profiling Active Enzymes for Polysorbate Degradation in Biotherapeutics by Activity-Based Protein Profiling.

Authors: Li X Chandra D Letarte S et al.

Source: Analytical chemistry [Anal Chem] 2021 Jun 15; Vol. 93 (23), pp. 8161-8169. Date of Electronic Publication: 2021 May 25.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE

Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction.

Authors: Beshore DC Adam GC Barnard RJO et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Mar 07; Vol. 12 (4), pp. 540-547. Date of Electronic Publication: 2021 Mar 07 (Print Publication: 2021).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE