Search Results - "Adam LP"

Systemic delivery of AAV5, AAV8, and AAV9 packaging a C5-12-microdystrophin-FLAG expression cassette in non-human primates.

Authors: Liu M Cook E Dai Y et al.

Source: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2025 Jan 17; Vol. 33 (1), pp. 101411. Date of Electronic Publication: 2025 Jan 17 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101624857 Publication Model: eCollection Cited Medium: Print ISSN: 2329-0501 (Print) Linking ISSN: 23290501 NLM ISO Abbreviation: Mol Ther Methods Clin Dev Subsets: PubMed not MEDLINE

Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors.

Authors: Hu Z Sitkoff D Glunz PW et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 May 15; Vol. 88, pp. 129304. Date of Electronic Publication: 2023 Apr 28.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.

Authors: Axelsson Raja A Wakimoto H DeLaughter DM et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Jul 12; Vol. 119 (28), pp. e2204174119. Date of Electronic Publication: 2022 Jul 05.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors.

Authors: Hu Z Wang C Sitkoff D et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Nov 01; Vol. 30 (21), pp. 127474. Date of Electronic Publication: 2020 Aug 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies.

Authors: Hu Z Wang C Glunz PW et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Nov 01; Vol. 30 (21), pp. 127495. Date of Electronic Publication: 2020 Aug 13.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

LC/MS/MS-based quantitation of pig and human S100A1 protein in cardiac tissues: Application to gene therapy.

Authors: Sleczka BG Levesque PC Adam LP et al.

Source: Analytical biochemistry [Anal Biochem] 2020 Aug 01; Vol. 602, pp. 113766. Date of Electronic Publication: 2020 May 08.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0370535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0309 (Electronic) Linking ISSN: 00032697 NLM ISO Abbreviation: Anal Biochem Subsets: MEDLINE

Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL-C Increase In Vivo.

Authors: Tora G Kim SH Pi Z et al.

Source: Journal of medicinal chemistry [J Med Chem] 2020 Feb 27; Vol. 63 (4), pp. 1660-1670. Date of Electronic Publication: 2020 Feb 11.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Benzothiazole-based compounds as potent endothelial lipase inhibitors.

Authors: Meng W Adam LP Behnia K et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Oct 15; Vol. 29 (20), pp. 126673. Date of Electronic Publication: 2019 Sep 06.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Corrigendum to "Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase" [Bioorg. Med. Chem. Lett. 29 (2019) 1918-1921].

Authors: Kim SH Johnson JA Jiang J et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Sep 01; Vol. 29 (17), pp. 2525. Date of Electronic Publication: 2019 Jul 25.

Publication Type: Published Erratum

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE; PubMed not MEDLINE

Inhibition of ERK attenuates force development by lowering myosin light chain phosphorylation.

Authors: D'Angelo G Adam LP

Source: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2002 Feb; Vol. 282 (2), pp. H602-10.

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print Cited Medium: Print ISSN: 0363-6135 (Print) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE

Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase.

Authors: Kim SH Johnson JA Jiang J et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Aug 01; Vol. 29 (15), pp. 1918-1921. Date of Electronic Publication: 2019 May 25.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE; PubMed not MEDLINE

Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor.

Authors: Finlay HJ Jiang J Rampulla R et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 May 06; Vol. 10 (6), pp. 911-916. Date of Electronic Publication: 2019 May 06 (Print Publication: 2019).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Evidence for modulation of smooth muscle force by the p38 MAP kinase/HSP27 pathway.

Authors: Yamboliev IA Hedges JC Mutnick JL et al.

Source: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2000 Jun; Vol. 278 (6), pp. H1899-907.

Publication Type: Journal Article

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print Cited Medium: Print ISSN: 0363-6135 (Print) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE

Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle.

Authors: Hedges JC Oxhorn BC Carty M et al.

Source: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2000 Apr; Vol. 278 (4), pp. C718-26.

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print Cited Medium: Print ISSN: 0363-6143 (Print) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE

Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors.

Authors: Hu CH Wang TC Qiao JX et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Dec 15; Vol. 28 (23-24), pp. 3721-3725. Date of Electronic Publication: 2018 Oct 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Development of a Chemiluminescent ELISA Method for the Detection of Total Anti-Adeno Associated Virus Serotype 9 (AAV9) Antibodies.

Authors: Kavita U Dai Y Salvador L et al.

Source: Human gene therapy methods [Hum Gene Ther Methods] 2018 Dec; Vol. 29 (6), pp. 237-250. Date of Electronic Publication: 2018 Nov 22.

Publication Type: Journal Article

Journal Info: Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 101573202 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6544 (Electronic) Linking ISSN: 19466536 NLM ISO Abbreviation: Hum Gene Ther Methods

Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase.

Authors: Johnson JA Tora G Pi Z et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Nov 21; Vol. 9 (12), pp. 1263-1268. Date of Electronic Publication: 2018 Nov 21 (Print Publication: 2018).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor.

Authors: Hangeland JJ Abell LM Adam LP et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Jun 15; Vol. 9 (7), pp. 673-678. Date of Electronic Publication: 2018 Jun 15 (Print Publication: 2018).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Oral Delivery of Highly Lipophilic, Poorly Water-Soluble Drugs: Self-Emulsifying Drug Delivery Systems to Improve Oral Absorption and Enable High-Dose Toxicology Studies of a Cholesteryl Ester Transfer Protein Inhibitor in Preclinical Species.

Authors: Chen XQ Ziemba T Huang C et al.

Source: Journal of pharmaceutical sciences [J Pharm Sci] 2018 May; Vol. 107 (5), pp. 1352-1360. Date of Electronic Publication: 2018 Jan 06.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311).

Authors: Qiao JX Wang TC Adam LP et al.

Source: Journal of medicinal chemistry [J Med Chem] 2015 Nov 25; Vol. 58 (22), pp. 9010-26. Date of Electronic Publication: 2015 Nov 17.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE