Search Results - "Beisel CL"

Target RNA-triggered CRISPR-Cas12a2 preferentially cleaves collateral DNA over RNA.

Authors: Kunwar S Hallmark T Manna S et al.

Source: Nucleic acids research [Nucleic Acids Res] 2026 Jun 08; Vol. 54 (11).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

A leader-repeat hairpin blocks extraneous CRISPR RNA production in diverse CRISPR-Cas13 systems.

Authors: Migur A Feussner M Liao C et al.

Source: The EMBO journal [EMBO J] 2026 May; Vol. 45 (10), pp. 3396-3415. Date of Electronic Publication: 2026 Apr 02.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

YprA-family helicases provide the missing link between diverse prokaryotic immune systems.

Authors: Bell RT Gaudin T Wu Y et al.

Source: Cell host & microbe [Cell Host Microbe] 2026 Jul 08; Vol. 34 (7), pp. 1430-1444.e3. Date of Electronic Publication: 2026 Jun 11.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE

RNA-triggered cell killing with CRISPR-Cas12a2.

Authors: Scholz P Thompson J Crosby KT et al.

Source: Nature [Nature] 2026 Jul; Vol. 655 (8121), pp. 230-239. Date of Electronic Publication: 2026 May 06.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes.

Authors: Gupta D Patinios C Bassett HV et al.

Source: Nature biotechnology [Nat Biotechnol] 2026 Jul; Vol. 44 (7), pp. 1190-1201. Date of Electronic Publication: 2025 Sep 04.

Publication Type: Journal Article

Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

Target RNA-triggered CRISPR-Cas12a2 Preferentially Cleaves Collateral DNA over RNA.

Authors: Kunwar S Hallmark T Manna S et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 30. Date of Electronic Publication: 2026 May 30.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Guide DNA - not RNA - expands the CRISPR toolkit.

Authors: Beisel CL; Botnar Institute of Immune Engineering, Basel, Switzerland. chase.beisel@immune.engineering.

Source: Nature biotechnology [Nat Biotechnol] 2026 May 15. Date of Electronic Publication: 2026 May 15.

Publication Type: Journal Article

Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

PAM-interacting domain turn-helix 51 motifs can improve Cas9-SpRY activity.

Authors: Eggenschwiler R Hoffmann T Dmytrenko O et al.

Source: Nucleic acids research [Nucleic Acids Res] 2025 Aug 11; Vol. 53 (15).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Comprehensive analysis of CRISPR array repeat mutations reveals subtype-specific patterns and links to spacer dynamics.

Authors: Mitrofanov A Beisel CL Baumdicker F et al.

Source: MicroLife [Microlife] 2026 Jan 06; Vol. 7, pp. uqaf050. Date of Electronic Publication: 2026 Jan 06 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9918227365406676 Publication Model: eCollection Cited Medium: Internet ISSN: 2633-6693 (Electronic) Linking ISSN: 26336693 NLM ISO Abbreviation: Microlife Subsets: PubMed not MEDLINE

RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity.

Authors: Dmytrenko O Yuan B Crosby KT et al.

Source: Nature [Nature] 2026 Jan; Vol. 649 (8099), pp. 1312-1321. Date of Electronic Publication: 2026 Jan 07.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

An updated evolutionary classification of CRISPR-Cas systems including rare variants.

Authors: Makarova KS Shmakov SA Wolf YI et al.

Source: Nature microbiology [Nat Microbiol] 2025 Dec; Vol. 10 (12), pp. 3346-3361. Date of Electronic Publication: 2025 Nov 06.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE

MprF-mediated immune evasion is necessary for Lactiplantibacillus plantarum resilience in the Drosophila gut during inflammation.

Authors: Arias-Rojas A Arifah AQ Angelidou G et al.

Source: PLoS pathogens [PLoS Pathog] 2024 Aug 19; Vol. 20 (8), pp. e1012462. Date of Electronic Publication: 2024 Aug 19 (Print Publication: 2024).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

TracrRNA reprogramming enables direct PAM-independent detection of RNA with diverse DNA-targeting Cas12 nucleases.

Authors: Jiao C Peeck NL Yu J et al.

Source: Nature communications [Nat Commun] 2024 Jul 13; Vol. 15 (1), pp. 5909. Date of Electronic Publication: 2024 Jul 13.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Systematic interrogation of CRISPR antimicrobials in Klebsiella pneumoniae reveals nuclease-, guide- and strain-dependent features influencing antimicrobial activity.

Authors: Vialetto E Miele S Goren MG et al.

Source: Nucleic acids research [Nucleic Acids Res] 2024 Jun 10; Vol. 52 (10), pp. 6079-6091.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection.

Authors: Jabalera Y Tascón I Samperio S et al.

Source: Nature biotechnology [Nat Biotechnol] 2025 Oct; Vol. 43 (10), pp. 1663-1672. Date of Electronic Publication: 2024 Oct 31.

Publication Type: Journal Article

Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

YprA family helicases provide the missing link between diverse prokaryotic immune systems.

Authors: Bell RT Gaudin T Wu Y et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Sep 15. Date of Electronic Publication: 2025 Sep 15.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Expanding the flexibility of base editing for high-throughput genetic screens in bacteria.

Authors: Gawlitt S Collins SP Yu Y et al.

Source: Nucleic acids research [Nucleic Acids Res] 2024 Apr 24; Vol. 52 (7), pp. 4079-4097.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

A Hitchhiker's guide to CRISPR editing tools in bacteria : CRISPR can help unlock the bacterial world, but technical and regulatory barriers persist.

Authors: Krink N Nikel PI Beisel CL

Source: EMBO reports [EMBO Rep] 2024 Apr; Vol. 25 (4), pp. 1694-1699. Date of Electronic Publication: 2024 Feb 12.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE

Interrogating two extensively self-targeting Type I CRISPR-Cas systems in Xanthomonas albilineans reveals distinct anti-CRISPR proteins that block DNA degradation.

Authors: Wimmer F Englert F Wandera KG et al.

Source: Nucleic acids research [Nucleic Acids Res] 2024 Jan 25; Vol. 52 (2), pp. 769-783.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Improved prediction of bacterial CRISPRi guide efficiency from depletion screens through mixed-effect machine learning and data integration.

Authors: Yu Y Gawlitt S de Andrade E Sousa LB et al.

Source: Genome biology [Genome Biol] 2024 Jan 11; Vol. 25 (1), pp. 13. Date of Electronic Publication: 2024 Jan 11.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE