Search Results - "Burkard MR"

Targeting ubiquitin signaling vulnerabilities in KEAP1-inactivated lung cancer.

Authors: Shah VJ Hartmann O Wegner M et al.

Source: The EMBO journal [EMBO J] 2026 May; Vol. 45 (9), pp. 3276-3305. Date of Electronic Publication: 2026 Mar 20.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

Mapping the global landscape of molecular glues in drug discovery: a bibliometric analysis from 2010 to 2024.

Authors: Labhade S Bhole R Karwa P et al.

Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Feb; Vol. 399 (3), pp. 4321-4339. Date of Electronic Publication: 2025 Oct 18.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

Evolution of direct RAS inhibitors: from undruggable target to clinical breakthroughs.

Authors: Wang, Xia Wu, Jing Xiao, Aotian et al.

Source: Molecular Cancer. 9/24/2025, Vol. 24 Issue 1, p1-21. 21p.

Modeling receptor flexibility in the structure-based design of KRASG12C inhibitors.

Authors: Zhu, Kai Li, Cui Wu, Kingsley Y. et al.

Source: Journal of Computer-Aided Molecular Design; Aug2022, Vol. 36 Issue 8, p591-604, 14p

Emergence and Targeting of Acquired and Hereditary Resistance to Multikinase RET Inhibition in Patients With RET-Altered Cancer.

Authors: Wirth LJ Kohno T Udagawa H et al.

Source: JCO precision oncology [JCO Precis Oncol] 2019 Sep 11; Vol. 3. Date of Electronic Publication: 2019 Sep 11 (Print Publication: 2019).

Publication Type: Case Reports; Journal Article

Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 101705370 Publication Model: eCollection Cited Medium: Internet ISSN: 2473-4284 (Electronic) Linking ISSN: 24734284 NLM ISO Abbreviation: JCO Precis Oncol Subsets: PubMed not MEDLINE

Targeting the BCR::ABL1 Kinase: Advances Beyond Imatinib in Chronic Myeloid Leukemia.

Authors: Naderi Z Sadras T Branford S et al.

Source: Current hematologic malignancy reports [Curr Hematol Malig Rep] 2026 Apr 25; Vol. 21 (1). Date of Electronic Publication: 2026 Apr 25.

Publication Type: Journal Article; Review

Journal Info: Publisher: Current Science Country of Publication: United States NLM ID: 101262565 Publication Model: Electronic Cited Medium: Internet ISSN: 1558-822X (Electronic) Linking ISSN: 15588211 NLM ISO Abbreviation: Curr Hematol Malig Rep Subsets: MEDLINE

The polyamine inhibitor SAM486A increases the efficacy of adagrasib in non-small cell lung cancer cells harboring KRAS^G12C mutation.

Authors: Martin-Martin A Chipón C Guzman-Kunstmann C et al.

Source: Biological research [Biol Res] 2026 Feb 19; Vol. 59 (1). Date of Electronic Publication: 2026 Feb 19.

Publication Type: Journal Article

Journal Info: Publisher: Biomed Central, Ltd Country of Publication: England NLM ID: 9308271 Publication Model: Electronic Cited Medium: Internet ISSN: 0717-6287 (Electronic) Linking ISSN: 07169760 NLM ISO Abbreviation: Biol Res Subsets: MEDLINE

Synthesis and in vitro evaluation of benzo[b]thiophene-3-carboxylic acid 1,1-dioxide derivatives as anticancer agents targeting the RhoA/ROCK pathway.

Authors: Liang, Jinhao Huang, Jin Yang, Jianzhan et al.

Source: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2024, Vol. 39 Issue 1, p1-15. 15p.

A single center analysis of first-line treatment in advanced KRAS mutant non-small cell lung cancer: real-world practice.

Authors: Liu, Yanxia Gao, Yuan Wang, Ying et al.

Source: BMC Cancer. 11/16/2022, p1-14. 14p.

Molecular docking analysis reveals differential binding affinities of multiple classes of selective inhibitors towards cancer-associated KRAS mutants.

Authors: Mullaguri, Sai Charitha Akula, Sravani Sahoo, Partha Sarathi et al.

Source: 3 Biotech. 11/6/2022, Vol. 12 Issue 12, p1-8. 8p.

Absorption, single-dose and steady-state metabolism, excretion, and pharmacokinetics of adagrasib, a KRAS^G12C inhibitor.

Authors: Rahbaek L Cilliers C Wegerski CJ et al.

Source: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2024 Dec 19; Vol. 95 (1), pp. 7. Date of Electronic Publication: 2024 Dec 19.

Publication Type: Journal Article

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

An overview of recent advancements in small molecules suppression of oncogenic signaling of K-RAS: an updated review.

Authors: Sabt A Tawfik HO Khaleel EF et al.

Source: Molecular diversity [Mol Divers] 2024 Dec; Vol. 28 (6), pp. 4581-4608. Date of Electronic Publication: 2024 Jan 30.

Publication Type: Journal Article; Review

Journal Info: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.

Authors: Fell JB Fischer JP Baer BR et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Nov 07; Vol. 9 (12), pp. 1230-1234. Date of Electronic Publication: 2018 Nov 07 (Print Publication: 2018).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Modeling receptor flexibility in the structure-based design of KRAS^G12C inhibitors.

Authors: Zhu, Kai Li, Cui Wu, Kingsley Y. et al.

Source: Journal of Computer-Aided Molecular Design. Aug2022, Vol. 36 Issue 8, p591-604. 14p.

Metabolic characterization of colorectal cancer cells harbouring different KRAS mutations in codon 12, 13, 61 and 146 using human SW48 isogenic cell lines.

Authors: Varshavi, Dorna Varshavi, Dorsa McCarthy, Nicola et al.

Source: Metabolomics. Apr2020, Vol. 16 Issue 4, p1-13. 13p.

miR-214-3p-Sufu-GLI1 is a novel regulatory axis controlling inflammatory smooth muscle cell differentiation from stem cells and neointimal hyperplasia.

Authors: He, Shiping Yang, Feng Yang, Mei et al.

Source: Stem Cell Research & Therapy. 11/3/2020, Vol. 11 Issue 1, pN.PAG-N.PAG. 1p.

Activation of the Kinin B1 Receptor Attenuates Melanoma Tumor Growth and Metastasis

Authors: Dillenburg-Pilla, Patricia Maria, Andrea G. Reis, Rosana I. et al.

Source: PLoS ONE. May2013, Vol. 8 Issue 5, p1-11. 11p.

Advancements in gene therapies targeting mutant KRAS in cancers.

Authors: Wang Y Bui TA Yang X et al.

Source: Cancer metastasis reviews [Cancer Metastasis Rev] 2025 Jan 17; Vol. 44 (1), pp. 24. Date of Electronic Publication: 2025 Jan 17.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8605731 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7233 (Electronic) Linking ISSN: 01677659 NLM ISO Abbreviation: Cancer Metastasis Rev Subsets: MEDLINE

CSC01 shows promise as a potential inhibitor of the oncogenic G13D mutant of KRAS: an in silico approach.

Authors: Durojaye OA Ejaz U Uzoeto HO et al.

Source: Amino acids [Amino Acids] 2023 Dec; Vol. 55 (12), pp. 1745-1764. Date of Electronic Publication: 2023 Jul 27.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 9200312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1438-2199 (Electronic) Linking ISSN: 09394451 NLM ISO Abbreviation: Amino Acids Subsets: MEDLINE

Pharmacophoric analogs of sotorasib-entrapped KRAS G12C in its inactive GDP-bound conformation: covalent docking and molecular dynamics investigations.

Authors: Oyedele AK Ogunlana AT Boyenle ID et al.

Source: Molecular diversity [Mol Divers] 2023 Aug; Vol. 27 (4), pp. 1795-1807. Date of Electronic Publication: 2022 Oct 21.

Publication Type: Journal Article

Journal Info: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE