Search Results - "Burkholder TP"

LY3410738, a Covalent Inhibitor of Mutant IDH1/2, is Effective in Acute Myeloid Leukemia Preclinical Models.

Authors: Brooks NA Skwarska A Salama V et al.

Source: Blood cancer discovery [Blood Cancer Discov] 2026 Jul 23. Date of Electronic Publication: 2026 Jul 23.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101764786 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2643-3249 (Electronic) Linking ISSN: 26433230 NLM ISO Abbreviation: Blood Cancer Discov Subsets: MEDLINE

Discovery of LY2457546: a multi-targeted anti-angiogenic kinase inhibitor with a novel spectrum of activity and exquisite potency in the acute myelogenous leukemia-Flt-3-internal tandem duplication mutant human tumor xenograft model.

Authors: Burkholder TP Clayton JR Rempala ME et al.

Source: Investigational new drugs [Invest New Drugs] 2012 Jun; Vol. 30 (3), pp. 936-49. Date of Electronic Publication: 2011 Mar 01.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 8309330 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-0646 (Electronic) Linking ISSN: 01676997 NLM ISO Abbreviation: Invest New Drugs Subsets: MEDLINE

Developing and applying a gene functional association network for anti-angiogenic kinase inhibitor activity assessment in an angiogenesis co-culture model.

Authors: Chen Y Wei T Yan L et al.

Source: BMC genomics [BMC Genomics] 2008 Jun 02; Vol. 9, pp. 264. Date of Electronic Publication: 2008 Jun 02.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100965258 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2164 (Electronic) Linking ISSN: 14712164 NLM ISO Abbreviation: BMC Genomics Subsets: MEDLINE

Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.

Authors: Parthasarathy S Henry K Pei H et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Jun 01; Vol. 28 (10), pp. 1887-1891. Date of Electronic Publication: 2018 Apr 02.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Discovery of a Highly Selective NAMPT Inhibitor That Demonstrates Robust Efficacy and Improved Retinal Toxicity with Nicotinic Acid Coadministration.

Authors: Zhao G Green CF Hui YH et al.

Source: Molecular cancer therapeutics [Mol Cancer Ther] 2017 Dec; Vol. 16 (12), pp. 2677-2688. Date of Electronic Publication: 2017 Oct 20.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptor β agonists.

Authors: Burkholder TP Cunningham BE Clayton JR et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Apr 01; Vol. 25 (7), pp. 1377-80. Date of Electronic Publication: 2015 Mar 03.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F.

Authors: Ma L Clayton JR Walgren RA et al.

Source: Blood cancer journal [Blood Cancer J] 2013 Apr 12; Vol. 3, pp. e109. Date of Electronic Publication: 2013 Apr 12.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101568469 Publication Model: Electronic Cited Medium: Print ISSN: 2044-5385 (Print) Linking ISSN: 20445385 NLM ISO Abbreviation: Blood Cancer J Subsets: PubMed not MEDLINE

Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications.

Authors: Tan B Young DA Lu ZH et al.

Source: The Journal of biological chemistry [J Biol Chem] 2013 Feb 01; Vol. 288 (5), pp. 3500-11. Date of Electronic Publication: 2012 Dec 13.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics.

Authors: Wacheck V Lahn M Dickinson G et al.

Source: Cancer management and research [Cancer Manag Res] 2011; Vol. 3, pp. 157-75. Date of Electronic Publication: 2011 May 10.

Publication Type: Journal Article

Journal Info: Publisher: Dove Medical Press Country of Publication: New Zealand NLM ID: 101512700 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1322 (Electronic) Linking ISSN: 11791322 NLM ISO Abbreviation: Cancer Manag Res Subsets: PubMed not MEDLINE

The development of potent and selective bisarylmaleimide GSK3 inhibitors.

Authors: Engler TA Malhotra S Burkholder TP et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Feb 15; Vol. 15 (4), pp. 899-903.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Substituted 3-imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino-[6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as highly selective and potent inhibitors of glycogen synthase kinase-3.

Authors: Engler TA Henry JR Malhotra S et al.

Source: Journal of medicinal chemistry [J Med Chem] 2004 Jul 29; Vol. 47 (16), pp. 3934-7.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

The peripheral NK-1/NK-2 receptor antagonist MDL 105,172A inhibits tachykinin-mediated respiratory effects in guinea-pigs.

Authors: Kudlacz EM Knippenberg RW Shatzer SA et al.

Source: Journal of autonomic pharmacology [J Auton Pharmacol] 1997 Apr; Vol. 17 (2), pp. 109-19.

Publication Type: Journal Article

Journal Info: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8106455 Publication Model: Print Cited Medium: Print ISSN: 0144-1795 (Print) Linking ISSN: 01441795 NLM ISO Abbreviation: J Auton Pharmacol Subsets: MEDLINE

Effect of MDL 105,212, a nonpeptide NK-1/NK-2 receptor antagonist in an allergic guinea pig model.

Authors: Kudlacz EM Knippenberg RW Logan DE et al.

Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 1996 Nov; Vol. 279 (2), pp. 732-9.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print Cited Medium: Print ISSN: 0022-3565 (Print) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

In vitro and in vivo characterization of MDL 105,212A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist.

Authors: Kudlacz EM Shatzer SA Knippenberg RW et al.

Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 1996 May; Vol. 277 (2), pp. 840-51.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print Cited Medium: Print ISSN: 0022-3565 (Print) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE