Search Results - "Burlein, Christine"

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Development of a sensitive amplified luminescent proximity homogeneous assay to monitor the interactions between pTEFb and Tat.

Authors: Burlein, Christine Bahnck, Carolyn Bhatt, Triveni et al.

Source: Analytical Biochemistry. Nov2014, Vol. 465, p164-171. 8p.

Novel Pan-Coronavirus 3CL Protease Inhibitor MK-7845: Biological and Pharmacological Profiling.

Authors: Alvarez, Nadine Adam, Gregory C. Howe, John A. et al.

Source: Viruses (1999-4915). Jul2024, Vol. 16 Issue 7, p1158. 22p.

Discovery of arylsulfonamides as a novel class of allosteric integrase inhibitors with antiviral activity.

Authors: Wang, Cheng Adam, Gregory C. Burlein, Christine et al.

Source: Bioorganic & Medicinal Chemistry Letters. Jun2023, Vol. 89, pN.PAG-N.PAG. 1p.

Structural optimization of cyclic sulfonamide based novel HIV-1 protease inhibitors to picomolar affinities guided by X-ray crystallographic analysis.

Authors: Ganguly, Ashit K. Alluri, Sesha S. Wang, Chih-Hung et al.

Source: Tetrahedron. May2014, Vol. 70 Issue 18, p2894-2904. 11p.

Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2–P4 linkers

Authors: Rudd, Michael T. McIntyre, Charles J. Romano, Joseph J. et al.

Source: Bioorganic & Medicinal Chemistry Letters. Dec2012, Vol. 22 Issue 23, p7207-7213. 7p.

Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease

Authors: Rudd, Michael T. McCauley, John A. Romano, Joseph J. et al.

Source: Bioorganic & Medicinal Chemistry Letters. Dec2012, Vol. 22 Issue 23, p7201-7206. 6p.

Epsilon substituted lysinol derivatives as HIV-1 protease inhibitors

Authors: Jones, Kristen L.G. Holloway, M. Katharine Su, Hua-Poo et al.

Source: Bioorganic & Medicinal Chemistry Letters. Jul2010, Vol. 20 Issue 14, p4065-4068. 4p.

Purification of untagged HIV-1 reverse transcriptase by affinity chromatography

Authors: Lu, Meiqing Ngo, Winnie Mei, Ye et al.

Source: Protein Expression & Purification. Jun2010, Vol. 71 Issue 2, p231-239. 9p.

A time-resolved, internally quenched fluorescence assay to characterize inhibition of hepatitis C virus nonstructural protein 3–4A protease at low enzyme concentrations

Authors: Mao, Shi-Shan DiMuzio, Jillian McHale, Carolyn et al.

Source: Analytical Biochemistry. Feb2008, Vol. 373 Issue 1, p1-8. 8p.

Synthesis and HCV inhibitory properties of 9-deaza- and 7,9-dideaza-7-oxa-2′-C-methyladenosine

Authors: Butora, Gabor Olsen, David B. Carroll, Steven S. et al.

Source: Bioorganic & Medicinal Chemistry. Aug2007, Vol. 15 Issue 15, p5219-5229. 11p.

Electrochemiluminescence assay for basic carboxypeptidases: inhibition of basic carboxypeptidases and activation of thrombin-activatable fibrinolysis inhibitor

Authors: Mao, Shi-Shan Colussi, Dennis Bailey, Carolyn M. et al.

Source: Analytical Biochemistry. Aug2003, Vol. 319 Issue 1, p159. 12p.

A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.

Authors: Cosden, Mali Jinn, Sarah Yao, Lihang et al.

Source: Neurobiology of Disease. Nov2021, Vol. 159, pN.PAG-N.PAG. 1p.

Correction to Design,Synthesis, and X-ray Crystallographic Analysis of a Novel Class ofHIV-1 Protease Inhibitors.

Authors: Ganguly, Ashit K. Alluri, Sesha S. Caroccia, Danielle et al.

Source: Journal of Medicinal Chemistry. Jun2012, Vol. 55 Issue 11, p5647-5647. 1p.

MK-5172, a Novel Macrocyclic Inhibitor of NS3/4a Protease Demonstrates Efficacy Against Viral Resistance in the Chimpanzee Model of Chronic Hepatitis C Virus Infection

Authors: Ludmerer, Steve Carroll, Steve McCauley, John et al.

Source: Antiviral Research. Apr2010, Vol. 86 Issue 1, pA21-A21. 1p.

Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure-Activity Relationships.

Authors: Plotkin MA Labroli M Schubert J et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Jul 09; Vol. 15 (8), pp. 1232-1241. Date of Electronic Publication: 2024 Jul 09 (Print Publication: 2024).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.

Authors: Shurtleff VW Layton ME Parish CA et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 3935-3958. Date of Electronic Publication: 2024 Feb 16.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase.

Authors: Hayes RP Heo MR Mason M et al.

Source: Nature communications [Nat Commun] 2021 May 24; Vol. 12 (1), pp. 3040. Date of Electronic Publication: 2021 May 24.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections.

Authors: Loughran HM Schirripa KM Roecker AJ et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Dec 21; Vol. 15 (1), pp. 123-131. Date of Electronic Publication: 2023 Dec 21 (Print Publication: 2024).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.

Authors: Roecker AJ Schirripa KM Loughran HM et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Jan 12; Vol. 14 (2), pp. 146-155. Date of Electronic Publication: 2023 Jan 12 (Print Publication: 2023).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE