Search Results - "Burlein C"

39 MK-5172: A NOVEL HCV NS3/4A PROTEASE INHIBITOR WITH POTENT ACTIVITY AGAINST KNOWN RESISTANCE MUTANTS

Authors: Carroll, S. McCauley, J. Ludmerer, S. et al.

Source: Journal of Hepatology. Apr2010 Supplement 1, Vol. 52, pS17-S17. 1p.

Evaluation of MK-7009, A Novel Macrocyclic Inhibitor of NS3/4A Protease, in the Chimpanzee Model of Chronic Hepatitis C Virus Infection

Authors: Ludmerer, S. Graham, D. Handt, L. et al.

Source: Antiviral Research. May2008, Vol. 78 Issue 2, pA23-A23. 1p.

Novel Pan-Coronavirus 3CL Protease Inhibitor MK-7845: Biological and Pharmacological Profiling.

Authors: Alvarez N Adam GC Howe JA et al.

Source: Viruses [Viruses] 2024 Jul 18; Vol. 16 (7). Date of Electronic Publication: 2024 Jul 18.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure-Activity Relationships.

Authors: Plotkin MA Labroli M Schubert J et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Jul 09; Vol. 15 (8), pp. 1232-1241. Date of Electronic Publication: 2024 Jul 09 (Print Publication: 2024).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.

Authors: Shurtleff VW Layton ME Parish CA et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 3935-3958. Date of Electronic Publication: 2024 Feb 16.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase.

Authors: Hayes RP Heo MR Mason M et al.

Source: Nature communications [Nat Commun] 2021 May 24; Vol. 12 (1), pp. 3040. Date of Electronic Publication: 2021 May 24.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections.

Authors: Loughran HM Schirripa KM Roecker AJ et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Dec 21; Vol. 15 (1), pp. 123-131. Date of Electronic Publication: 2023 Dec 21 (Print Publication: 2024).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Discovery of arylsulfonamides as a novel class of allosteric integrase inhibitors with antiviral activity.

Authors: Wang C Adam GC Burlein C et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Jun 01; Vol. 89, pp. 129303. Date of Electronic Publication: 2023 May 03.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.

Authors: Roecker AJ Schirripa KM Loughran HM et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Jan 12; Vol. 14 (2), pp. 146-155. Date of Electronic Publication: 2023 Jan 12 (Print Publication: 2023).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.

Authors: Cosden M Jinn S Yao L et al.

Source: Neurobiology of disease [Neurobiol Dis] 2021 Nov; Vol. 159, pp. 105507. Date of Electronic Publication: 2021 Sep 09.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE

Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction.

Authors: Beshore DC Adam GC Barnard RJO et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Mar 07; Vol. 12 (4), pp. 540-547. Date of Electronic Publication: 2021 Mar 07 (Print Publication: 2021).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

P2-quinazolinones and bis-macrocycles as new templates for next-generation hepatitis C virus NS3/4a protease inhibitors: discovery of MK-2748 and MK-6325.

Authors: Rudd MT Butcher JW Nguyen KT et al.

Source: ChemMedChem [ChemMedChem] 2015 Apr; Vol. 10 (4), pp. 727-35. Date of Electronic Publication: 2015 Mar 10.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV-1 Integrase Inhibitors with Antiretroviral Activity.

Authors: Burlein C Wang C Xu M et al.

Source: ACS chemical biology [ACS Chem Biol] 2017 Nov 17; Vol. 12 (11), pp. 2858-2865. Date of Electronic Publication: 2017 Oct 19.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Structural characterization of nonactive site, TrkA-selective kinase inhibitors.

Authors: Su HP Rickert K Burlein C et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Jan 17; Vol. 114 (3), pp. E297-E306. Date of Electronic Publication: 2016 Dec 30.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Development of a sensitive amplified luminescent proximity homogeneous assay to monitor the interactions between pTEFb and Tat.

Authors: Burlein C Bahnck C Bhatt T et al.

Source: Analytical biochemistry [Anal Biochem] 2014 Nov 15; Vol. 465, pp. 164-71. Date of Electronic Publication: 2014 Aug 14.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0370535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0309 (Electronic) Linking ISSN: 00032697 NLM ISO Abbreviation: Anal Biochem Subsets: MEDLINE

Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.

Authors: Rudd MT McIntyre CJ Romano JJ et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Dec 01; Vol. 22 (23), pp. 7207-13. Date of Electronic Publication: 2012 Oct 02.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease.

Authors: Rudd MT McCauley JA Romano JJ et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Dec 01; Vol. 22 (23), pp. 7201-6. Date of Electronic Publication: 2012 Sep 07.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.

Authors: Summa V Ludmerer SW McCauley JA et al.

Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2012 Aug; Vol. 56 (8), pp. 4161-7. Date of Electronic Publication: 2012 May 21.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor.

Authors: Harper S McCauley JA Rudd MT et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2012 Mar 02; Vol. 3 (4), pp. 332-6. Date of Electronic Publication: 2012 Mar 02 (Print Publication: 2012).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Design, synthesis, and X-ray crystallographic analysis of a novel class of HIV-1 protease inhibitors.

Authors: Ganguly AK Alluri SS Caroccia D et al.

Source: Journal of medicinal chemistry [J Med Chem] 2011 Oct 27; Vol. 54 (20), pp. 7176-83. Date of Electronic Publication: 2011 Sep 26.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE