Search Results - "Butler DCD"

Harnessing sulfur-binding domains to separate Sp and Rp isomers of phosphorothioate oligonucleotides.

Authors: Ge, Fulin Wang, Yuli Liu, Jinling et al.

Source: Applied Microbiology & Biotechnology; 8/27/2024, Vol. 108 Issue 1, p1-14, 14p

Current CMC challenges in oligonucleotide API development: from IND to NDA.

Authors: Chen D Zhang X Xu S et al.

Source: Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents [Med Chem Res] 2026 Apr; Vol. 35 (4), pp. 711-725. Date of Electronic Publication: 2026 Apr 25.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9211347 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8120 (Electronic) Linking ISSN: 10542523 NLM ISO Abbreviation: Med Chem Res Subsets: MEDLINE

Chemical cleavage coupled with LCMS to report on the true diastereomeric distributions of phosphorothioate linkages in gapmer ASO.

Authors: Li Z Nguyen T Zhou X et al.

Source: Analytical and bioanalytical chemistry [Anal Bioanal Chem] 2026 Apr; Vol. 418 (8), pp. 2415-2425. Date of Electronic Publication: 2026 Feb 11.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101134327 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-2650 (Electronic) Linking ISSN: 16182642 NLM ISO Abbreviation: Anal Bioanal Chem Subsets: MEDLINE

Refining LNA safety profile by controlling phosphorothioate stereochemistry.

Authors: Funder, Erik Daa Albæk, Nanna Moisan, Annie et al.

Source: PLoS ONE. 6/12/2020, Vol. 15 Issue 6, p1-11. 11p.

BIOANALYSIS AND BIOTRANSFORMATION OF OLIGONUCLEOTIDE THERAPEUTICS BY LIQUID CHROMATOGRAPHY‐MASS SPECTROMETRY.

Authors: Sutton, James Michael Kim, Jaeah El Zahar, Noha M. et al.

Source: Mass Spectrometry Reviews. Jul2021, Vol. 40 Issue 4, p334-358. 25p.

THERAPEUTIC OLIGONUCLEOTIDES, IMPURITIES, DEGRADANTS, AND THEIR CHARACTERIZATION BY MASS SPECTROMETRY.

Authors: Pourshahian, Soheil¹ (AUTHOR) spoursha@its.jnj.com

Source: Mass Spectrometry Reviews. Mar2021, Vol. 40 Issue 2, p75-109. 35p.

Investigation of factors influencing the separation of diastereomers of phosphorothioated oligonucleotides.

Authors: Enmark, Martin Rova, Maria Samuelsson, Jörgen et al.

Source: Analytical & Bioanalytical Chemistry. Jun2019, Vol. 411 Issue 15, p3383-3394. 12p.

Genetic neuromuscular disorders: living the era of a therapeutic revolution. Part 2: diseases of motor neuron and skeletal muscle.

Authors: Vita, Giuseppe Vita, Gian Luca Musumeci, Olimpia et al.

Source: Neurological Sciences. Apr2019, Vol. 40 Issue 4, p671-681. 11p. 1 Chart.

Subjects: Glycogen storage disease type II, Motor neuron diseases, Neuromuscular diseases, United States. Food & Drug Administration, Genetic disorders, Duchenne muscular dystrophy, Skeletal muscle, Treatment of Duchenne muscular dystrophy, Mitochondrial pathology, Muscle disease treatment, Nucleotides, Treatment of spinal muscular atrophy, Heterocyclic compounds, Muscle relaxants, Carrier proteins, Gene therapy, Myotonia atrophica, Inborn errors of carbohydrate metabolism, Therapeutics

Huntington's Disease Clinical Trials Corner: February 2018.

Authors: Rodrigues, Filipe B. Wild, Edward J.

Source: Journal of Huntington's Disease. 2018, Vol. 7 Issue 1, p88-98. 10p.

Gene expression silencing therapy in tumors, focus on gastrointestinal and genitourinary tumors.

Authors: El-Ghazzi N Italiano A Angeli E

Source: Frontiers in immunology [Front Immunol] 2025 Oct 03; Vol. 16, pp. 1657040. Date of Electronic Publication: 2025 Oct 03 (Print Publication: 2025).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Introduction and History of the Chemistry of Nucleic Acids Therapeutics.

Authors: Gait MJ Agrawal S

Source: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2434, pp. 3-31.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

Control of backbone chemistry and chirality boost oligonucleotide splice switching activity.

Authors: Kandasamy P McClorey G Shimizu M et al.

Source: Nucleic acids research [Nucleic Acids Res] 2022 Jun 10; Vol. 50 (10), pp. 5443-5466.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Structural Fingerprinting of Antisense Oligonucleotide Therapeutics by Solution NMR Spectroscopy.

Authors: Becette OB Marino JP Brinson RG

Source: Pharmaceutical research [Pharm Res] 2023 Jun; Vol. 40 (6), pp. 1373-1382. Date of Electronic Publication: 2022 Oct 04.

Publication Type: Journal Article

Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE

Stereopure AIMer: A Promising RNA Base-editing Tool for Monogenic Neurological Diseases.

Authors: Yu J Li T Chen K et al.

Source: Neuroscience bulletin [Neurosci Bull] 2023 Feb; Vol. 39 (2), pp. 353-355. Date of Electronic Publication: 2022 Aug 22.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 101256850 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1995-8218 (Electronic) Linking ISSN: 19958218 NLM ISO Abbreviation: Neurosci Bull Subsets: MEDLINE

Therapeutic antisense oligonucleotides for movement disorders.

Authors: Doxakis E; Center of Basic Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece.

Source: Medicinal research reviews [Med Res Rev] 2021 Sep; Vol. 41 (5), pp. 2656-2688. Date of Electronic Publication: 2020 Jul 13.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 8103150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-1128 (Electronic) Linking ISSN: 01986325 NLM ISO Abbreviation: Med Res Rev Subsets: MEDLINE

Antisense therapies for movement disorders.

Authors: Scoles DR Pulst SM

Source: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2019 Aug; Vol. 34 (8), pp. 1112-1119. Date of Electronic Publication: 2019 Jul 08.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8610688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8257 (Electronic) Linking ISSN: 08853185 NLM ISO Abbreviation: Mov Disord Subsets: MEDLINE

From liquid-phase synthesis to chemical ligation: preparation of oligonucleotides and their backbone analogs in solution.

Authors: Virta P; Department of Chemistry, University of Turku, 20500, Finland.

Source: Nucleic acids research [Nucleic Acids Res] 2025 Oct 28; Vol. 53 (20).

Publication Type: Journal Article; Review

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Next generation APOBEC3 inhibitors: optimally designed for potency and nuclease stability.

Authors: Hedger AK Myint W Lee JM et al.

Source: Nucleic acids research [Nucleic Acids Res] 2025 Mar 20; Vol. 53 (6).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Evolution of antisense oligonucleotides: navigating nucleic acid chemistry and delivery challenges.

Authors: Ruchi R Raman GM Kumar V et al.

Source: Expert opinion on drug discovery [Expert Opin Drug Discov] 2025 Jan; Vol. 20 (1), pp. 63-80. Date of Electronic Publication: 2024 Dec 17.

Publication Type: Journal Article; Review

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101295755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1746-045X (Electronic) Linking ISSN: 17460441 NLM ISO Abbreviation: Expert Opin Drug Discov Subsets: MEDLINE

Post-transcriptional modification of m⁶A methylase METTL3 regulates ERK-induced androgen-deprived treatment resistance prostate cancer.

Authors: Li Y Zhu S Chen Y et al.

Source: Cell death & disease [Cell Death Dis] 2023 Apr 24; Vol. 14 (4), pp. 289. Date of Electronic Publication: 2023 Apr 24.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE