Search Results - "CHOLINESTERASE reactivators"

Novel chlorinated oxime K870 protects rats against paraoxon poisoning better than obidoxime.

Authors: Maksimović ŽM T Marinković S Đukanović Đ et al.

Source: Drug and chemical toxicology [Drug Chem Toxicol] 2025 Nov; Vol. 48 (6), pp. 1179-1189. Date of Electronic Publication: 2025 Jan 27.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 7801723 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6014 (Electronic) Linking ISSN: 01480545 NLM ISO Abbreviation: Drug Chem Toxicol Subsets: MEDLINE

The evaluation of HI-6 encapsulated in reconstituted lipid nanoparticles for central delivery and reactivation in soman-poisoned mice.

Authors: Zhuang T Zhao J Yang X et al.

Source: Neuroscience letters [Neurosci Lett] 2026 Jun 30; Vol. 881, pp. 138623. Date of Electronic Publication: 2026 May 07.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE

Next-generation broad-spectrum reactivators for effective countermeasure against organophosphorus poisoning.

Authors: Zdarova Karasova J Hrabinova M Dlabkova A et al.

Source: Archives of toxicology [Arch Toxicol] 2026 Jun; Vol. 100 (6), pp. 2467-2502. Date of Electronic Publication: 2026 Mar 16.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

Effect of HI-6-loaded brain-targeted metal-organic frameworks on reactivation of central nervous system enzymes.

Authors: Qin Y Li Q Fan N et al.

Source: Journal of pharmaceutical sciences [J Pharm Sci] 2026 May; Vol. 115 (5), pp. 104237. Date of Electronic Publication: 2026 Mar 06.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE

Non-oxime reactivators of organophosphate-inhibited cholinesterases.

Authors: Knittelova K Kohoutova Z Prchalova E et al.

Source: Archives of toxicology [Arch Toxicol] 2025 Aug; Vol. 99 (8), pp. 3315-3330. Date of Electronic Publication: 2025 May 03.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

Design, synthesis and evaluation of an uncharged broad spectrum quinoline-oxime hybrid for the reactivation of nerve agent-inhibited human acetylcholinesterase.

Authors: De Sousa J Calas AG De La Mora E et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Oct 15; Vol. 316, pp. 119023. Date of Electronic Publication: 2026 Jun 01.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

N,N'-dibenzyl imidazolium oximes are potent reactivators of organophosphate-inhibited human butyrylcholinesterase.

Authors: Kolić D Divjak T Šinko G et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Sep 05; Vol. 313, pp. 118895. Date of Electronic Publication: 2026 Apr 29.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging.

Authors: Čadež T Maček Hrvat N Šinko G et al.

Source: Archives of toxicology [Arch Toxicol] 2025 May; Vol. 99 (5), pp. 2107-2131. Date of Electronic Publication: 2025 Mar 03.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

In silico studies and in vitro evaluation of isatin-pyridine oxime hybrids as novel reactivators of acetylcholinesterase inhibited by an A-230 surrogate.

Authors: Bernardo LB Vieira LA Borges CVN et al.

Source: Archives of toxicology [Arch Toxicol] 2025 May; Vol. 99 (5), pp. 2225-2228. Date of Electronic Publication: 2025 Mar 04.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

Imidazole as a Pendant Reactivation Ligand Increases Efficacy Scope for Reactivation and Resurrection of Organophosphorus-Inhibited/Aged Cholinesterases by Quinone Methide Precursors.

Authors: Lovins AR Miller KA Homoelle RK et al.

Source: ACS chemical neuroscience [ACS Chem Neurosci] 2026 Mar 04; Vol. 17 (5), pp. 962-975. Date of Electronic Publication: 2026 Feb 19.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

Approaches to the treatment of nerve agent poisoning with oximes - from experimental studies to the intensive care unit.

Authors: Thiermann H Worek F Horn G

Source: Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2025 Jun; Vol. 63 (6), pp. 375-392. Date of Electronic Publication: 2025 May 27.

Publication Type: Journal Article; Review

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 101241654 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-9519 (Electronic) Linking ISSN: 15563650 NLM ISO Abbreviation: Clin Toxicol (Phila) Subsets: MEDLINE

Serine hydrolase targets of a sarin surrogate anticholinesterase and oxime-mediated reactivation in rat brain.

Authors: Price CY Meek EC Ross MK et al.

Source: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2026 Mar 02; Vol. 209 (3).

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Internet ISSN: 1096-0929 (Electronic) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE

Reactivation screening of A-234-inhibited human recombinant acetylcholinesterase in vitro.

Authors: Opravil J Pejchal J Hrabinova M et al.

Source: Chemico-biological interactions [Chem Biol Interact] 2026 Jan 05; Vol. 423, pp. 111810. Date of Electronic Publication: 2025 Nov 04.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

Outlining the A-series of organophosphorus compounds: Cholinesterase inhibition, reactivation, cytotoxicity, and acute toxicity in mice.

Authors: Kovarik Z Kolić D Čadež T et al.

Source: Chemico-biological interactions [Chem Biol Interact] 2025 Nov 01; Vol. 421, pp. 111762. Date of Electronic Publication: 2025 Sep 30.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents.

Authors: Prchalova E Andrys R Pejchal J et al.

Source: Archives of toxicology [Arch Toxicol] 2024 Sep; Vol. 98 (9), pp. 2937-2952. Date of Electronic Publication: 2024 May 24.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

Synthesis and in vitro assessment of the reactivation profile of clinically available oximes on the acetylcholinesterase model inhibited by A-230 nerve agent surrogate.

Authors: Bernardo LB Borges CVN Buitrago PAG et al.

Source: Archives of toxicology [Arch Toxicol] 2024 Oct; Vol. 98 (10), pp. 3397-3407. Date of Electronic Publication: 2024 Jul 14.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

Reactivation by novel pyridinium oximes of rat serum and skeletal muscle acetylcholinesterase inhibited by organophosphates.

Authors: Bennett JP Meek EC Chambers JE

Source: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2024 Jul; Vol. 38 (7), pp. e23750.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 9717231 Publication Model: Print Cited Medium: Internet ISSN: 1099-0461 (Electronic) Linking ISSN: 10956670 NLM ISO Abbreviation: J Biochem Mol Toxicol Subsets: MEDLINE

Targeted delivery of 2-PAM to the brain using cationic liposomes modified with lipid-like surfactants for the treatment of acute organophosphorus poisoning.

Authors: Kuznetsova DA Kuznetsov DM Gaynanova GA et al.

Source: Chemico-biological interactions [Chem Biol Interact] 2025 Oct 22; Vol. 420, pp. 111678. Date of Electronic Publication: 2025 Jul 28.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

Photochemistry-driven design of small molecule cholinesterase ligands.

Authors: Škorić I Sviben M Mlakić M et al.

Source: Chemico-biological interactions [Chem Biol Interact] 2025 Oct 22; Vol. 420, pp. 111703. Date of Electronic Publication: 2025 Aug 13.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE

Pralidoxime Is no Longer Fit for Purpose as an Antidote to Organophosphate Poisoning in the United Kingdom.

Authors: Corby G; St John's College, University of Oxford, Oxford, UK.

Source: Disaster medicine and public health preparedness [Disaster Med Public Health Prep] 2024 Feb 22; Vol. 18, pp. e32. Date of Electronic Publication: 2024 Feb 22.

Publication Type: Journal Article

Journal Info: Publisher: Cambridge University Press Country of Publication: United States NLM ID: 101297401 Publication Model: Electronic Cited Medium: Internet ISSN: 1938-744X (Electronic) Linking ISSN: 19357893 NLM ISO Abbreviation: Disaster Med Public Health Prep Subsets: MEDLINE