Search Results - "Capener JL"

Development of NanoBRET cellular target engagement assays in primary neurons for activating mutants of p21-activated kinase 1.

Authors: Capener JL Badillo-Martinez A Awada B et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 06. Date of Electronic Publication: 2026 May 06.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Smoothened and ciliary GPCRs regulate ciliary protein kinase A activity involved in Hedgehog signal transduction.

Authors: Nguyen, Thi D. Konjikusic, Mia J. Del Castillo, Lorenzo M. et al.

Source: PLoS Biology. 6/10/2026, Vol. 24 Issue 6, p1-26. 26p.

Development of a chemical probe to enable characterization of the casein kinase 1γ subfamily.

Authors: Capener JL Kramer TW Bashore FM et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Sep 16. Date of Electronic Publication: 2025 Sep 16.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Illumination of understudied ciliary kinases.

Authors: Flax RG Rosston P Rocha C et al.

Source: Frontiers in molecular biosciences [Front Mol Biosci] 2024 Mar 08; Vol. 11, pp. 1352781. Date of Electronic Publication: 2024 Mar 08 (Print Publication: 2024).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101653173 Publication Model: eCollection Cited Medium: Print ISSN: 2296-889X (Print) Linking ISSN: 2296889X NLM ISO Abbreviation: Front Mol Biosci Subsets: PubMed not MEDLINE

Development of SYK NanoBRET cellular target engagement assays for gain-of-function variants.

Authors: Capener JL Vasta JD Katis VL et al.

Source: Frontiers in chemical biology [Front Chem Biol] 2024; Vol. 3. Date of Electronic Publication: 2024 Jul 28.

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 9918716583206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2813-530X (Electronic) Linking ISSN: 2813530X NLM ISO Abbreviation: Front Chem Biol Subsets: PubMed not MEDLINE

Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits.

Authors: Arveseth CD Happ JT Hedeen DS et al.

Source: PLoS biology [PLoS Biol] 2021 Apr 22; Vol. 19 (4), pp. e3001191. Date of Electronic Publication: 2021 Apr 22 (Print Publication: 2021).

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.

Authors: Walker, Madison F. Zhang, Jingyi Steiner, William et al.

Source: PLoS Biology. 8/13/2024, Vol. 22 Issue 8, p1-41. 41p.

Caudal fin shape imprinted during late zebrafish embryogenesis is re-patterned by SONIC hedgehog.

Authors: Surette, Eric Donahue, Joan Soto Martinez, Crisvely et al.

Source: PLoS Biology. 8/25/2025, Vol. 23 Issue 8, p1-22. 22p.

Hedgehog-stimulated phosphorylation at multiple sites activates Ci by altering Ci–Ci interfaces without full Suppressor of Fused dissociation.

Authors: Kim, Hoyon Little, Jamie C. Li, Jiashen et al.

Source: PLoS Biology. 4/11/2025, Vol. 23 Issue 4, p1-37. 37p.

NEK8, a NIMA-family protein kinase at the core of the ciliary INV complex.

Authors: Roig, Joan¹ (AUTHOR) jrabmc@ibmb.csic.es

Source: Cell Communication & Signaling. 4/7/2025, Vol. 23 Issue 1, p1-20. 20p.

Protein kinases as therapeutic targets in Alzheimer's disease: challenges, insights, and new frontiers.

Authors: Tak C Bhujbal SP Hah JM

Source: Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents [Med Chem Res] 2026 Apr; Vol. 35 (4), pp. 726-756. Date of Electronic Publication: 2026 Apr 17.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9211347 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8120 (Electronic) Linking ISSN: 10542523 NLM ISO Abbreviation: Med Chem Res Subsets: MEDLINE

PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice.

Authors: Yang T Huhe H Williams SP et al.

Corporate Authors: Yang T Huhe H Williams SP et al.

Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Dec; Vol. 21 (12), pp. e71033.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

Hedgehog pathway, cell cycle, and primary cilium.

Authors: Zhuang T; Institute of Veterinary Immunology and Engineering, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China. zhuangtenghan@foxmail.com.; GuoTai (Taizhou) Center of Technology Innovation for Veterinary Biologicals, Taizhou, Jiangsu, China. zhuangtenghan@foxmail.com.

Source: Cell death discovery [Cell Death Discov] 2025 Jul 03; Vol. 11 (1), pp. 302. Date of Electronic Publication: 2025 Jul 03.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE

Therapeutic potential of astrocyte transdifferentiated neurons.

Authors: Liang X Qin R Qin Q et al.

Source: Neural regeneration research [Neural Regen Res] 2026 Oct 01; Vol. 21 (10), pp. 4854-4864. Date of Electronic Publication: 2025 Dec 30.

Publication Type: Journal Article

Journal Info: Publisher: Wolters Kluwer Health, Medknow Country of Publication: India NLM ID: 101316351 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1673-5374 (Print) Linking ISSN: 16735374 NLM ISO Abbreviation: Neural Regen Res Subsets: PubMed not MEDLINE

The hidden hedgehog of the pituitary: hedgehog signaling in development, adulthood and disease of the hypothalamic-pituitary axis.

Authors: Bian Y Hahn H Uhmann A

Source: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Jul 05; Vol. 14, pp. 1219018. Date of Electronic Publication: 2023 Jul 05 (Print Publication: 2023).

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE

A critical evaluation of protein kinase regulation by activation loop autophosphorylation.

Authors: Reinhardt R Leonard TA

Source: ELife [Elife] 2023 Jul 20; Vol. 12. Date of Electronic Publication: 2023 Jul 20.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation.

Authors: Hansen JN Kaiser F Leyendecker P et al.

Source: EMBO reports [EMBO Rep] 2022 Aug 03; Vol. 23 (8), pp. e54315. Date of Electronic Publication: 2022 Jun 13.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE

Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling.

Authors: Bosakova M Abraham SP Nita A et al.

Corporate Authors: Bosakova M Abraham SP Nita A et al.

Source: EMBO molecular medicine [EMBO Mol Med] 2020 Nov 06; Vol. 12 (11), pp. e11739. Date of Electronic Publication: 2020 Oct 14.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE