Search Results - "Cheff DM"

Development of therapies for rare genetic disorders of GPX4: roadmap and opportunities.

Authors: Cheff DM Muotri AR Stockwell BR et al.

Source: Orphanet journal of rare diseases [Orphanet J Rare Dis] 2021 Oct 23; Vol. 16 (1), pp. 446. Date of Electronic Publication: 2021 Oct 23.

Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101266602 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1172 (Electronic) Linking ISSN: 17501172 NLM ISO Abbreviation: Orphanet J Rare Dis Subsets: MEDLINE

Arsenic exposure and increased C-reactive protein are independently associated with lower erythrocyte glutathione peroxidase activity in Bangladeshi children.

Authors: Cheff DM Skröder H Akhtar E et al.

Source: Redox biochemistry and chemistry [Redox Biochem Chem] 2023 Dec; Vol. 5-6. Date of Electronic Publication: 2023 Sep 27.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 9918697481606676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2773-1766 (Electronic) Linking ISSN: 27731766 NLM ISO Abbreviation: Redox Biochem Chem Subsets: PubMed not MEDLINE

Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4.

Authors: Cheff DM Cheng Q Guo H et al.

Source: Redox biology [Redox Biol] 2023 Jul; Vol. 63, pp. 102719. Date of Electronic Publication: 2023 May 16.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE

The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1.

Authors: Cheff DM Huang C Scholzen KC et al.

Source: Redox biology [Redox Biol] 2023 Jun; Vol. 62, pp. 102703. Date of Electronic Publication: 2023 Apr 17.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural

Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE

Discovery and Optimization of 2H-1λ²-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.

Authors: Rohde JM Karavadhi S Pragani R et al.

Source: Journal of medicinal chemistry [J Med Chem] 2021 Apr 22; Vol. 64 (8), pp. 4913-4946. Date of Electronic Publication: 2021 Apr 06.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.

Authors: Rai G Urban DJ Mott BT et al.

Source: Journal of medicinal chemistry [J Med Chem] 2020 Oct 08; Vol. 63 (19), pp. 10984-11011. Date of Electronic Publication: 2020 Sep 27.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Keeping It Clean: The Cell Culture Quality Control Experience at the National Center for Advancing Translational Sciences.

Authors: Roth JS Lee TD Cheff DM et al.

Source: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2020 Jun; Vol. 25 (5), pp. 491-497. Date of Electronic Publication: 2020 Apr 01.

Publication Type: Journal Article; Research Support, N.I.H., Intramural

Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE

Predictive models for estimating cytotoxicity on the basis of chemical structures.

Authors: Sun H Wang Y Cheff DM et al.

Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 May 15; Vol. 28 (10), pp. 115422. Date of Electronic Publication: 2020 Mar 12.

Publication Type: Journal Article; Research Support, N.I.H., Intramural

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.

Authors: Lee OW Austin S Gamma M et al.

Source: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2020 Jan; Vol. 25 (1), pp. 9-20. Date of Electronic Publication: 2019 Sep 09.

Publication Type: Journal Article; Research Support, N.I.H., Intramural

Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

Authors: Kearney SE Zahoránszky-Kőhalmi G Brimacombe KR et al.

Source: ACS central science [ACS Cent Sci] 2018 Dec 26; Vol. 4 (12), pp. 1727-1741. Date of Electronic Publication: 2018 Dec 05.

Publication Type: Journal Article

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101660035 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2374-7943 (Print) Linking ISSN: 23747943 NLM ISO Abbreviation: ACS Cent Sci Subsets: PubMed not MEDLINE

Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling.

Authors: Iniguez AB Alexe G Wang EJ et al.

Source: Cancer cell [Cancer Cell] 2018 Dec 10; Vol. 34 (6), pp. 922-938.e7.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell

Correction to A Drug of Such Damned Nature. Challenges and Opportunities in Translational Platinum Drug Research.

Authors: Cheff DM Hall MD

Source: Journal of medicinal chemistry [J Med Chem] 2018 Oct 11; Vol. 61 (19), pp. 8944. Date of Electronic Publication: 2018 Sep 27.

Publication Type: Journal Article; Published Erratum

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: PubMed not MEDLINE

High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.

Authors: Coussens NP Kales SC Henderson MJ et al.

Source: The Journal of biological chemistry [J Biol Chem] 2018 Aug 31; Vol. 293 (35), pp. 13750-13765. Date of Electronic Publication: 2018 Jun 26.

Publication Type: Journal Article; Research Support, N.I.H., Intramural

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

Authors: Rohde JM Brimacombe KR Liu L et al.

Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2018 May 01; Vol. 26 (8), pp. 1727-1739. Date of Electronic Publication: 2018 Feb 27.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).

Authors: Rai G Brimacombe KR Mott BT et al.

Source: Journal of medicinal chemistry [J Med Chem] 2017 Nov 22; Vol. 60 (22), pp. 9184-9204. Date of Electronic Publication: 2017 Nov 09.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.

Authors: Urban DJ Martinez NJ Davis MI et al.

Source: Scientific reports [Sci Rep] 2017 Oct 06; Vol. 7 (1), pp. 12758. Date of Electronic Publication: 2017 Oct 06.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

A Drug of Such Damned Nature.1 Challenges and Opportunities in Translational Platinum Drug Research.

Authors: Cheff DM Hall MD

Source: Journal of medicinal chemistry [J Med Chem] 2017 Jun 08; Vol. 60 (11), pp. 4517-4532. Date of Electronic Publication: 2017 Feb 28.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE