Search Results - "Cihlar T"

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Comparative effects of adefovir and selected nucleoside inhibitors of hepatitis B virus DNA polymerase on mitochondrial DNA in liver and skeletal muscle cells.

Authors: Birkus, G. Gibbs, C. S. Cihlar, T.

Source: Journal of Viral Hepatitis. Jan2003, Vol. 10 Issue 1, p50-54. 5p.

394 IN VIVO ORAL DOSING OF THE TLR7 AGONIST GS-9620 INDUCES AN ANTI-VIRAL GENE EXPRESSION SIGNATURE IN MURINE LIVER CONCURRENT WITH UNDETECTABLE SERUM LEVELS OF IFN-a.

Authors: Pflanz, S. Fosdick, A. Cihlar, T. et al.

Source: Journal of Hepatology. Apr2013 Supplement 1, Vol. 58, pS162-S162. 1p.

Identification of key metabolic enzymes involved in the activation of obeldesivir and remdesivir to the active triphosphate metabolite.

Authors: Xu Y Liclican A Zhao X et al.

Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2026 Jun 22, pp. e0005526. Date of Electronic Publication: 2026 Jun 22.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys.

Authors: Pitts J Zamora JLR Manhas S et al.

Source: Nature communications [Nat Commun] 2025 Jul 11; Vol. 16 (1), pp. 6437. Date of Electronic Publication: 2025 Jul 11.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Remdesivir is active in vitro against tick-borne encephalitis virus and selects for resistance mutations in the viral RNA-dependent RNA polymerase.

Authors: Nyström K Trybala E Said J et al.

Source: Infectious diseases (London, England) [Infect Dis (Lond)] 2025 Jul; Vol. 57 (7), pp. 628-635. Date of Electronic Publication: 2025 Feb 20.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 101650235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2374-4243 (Electronic) Linking ISSN: 23744243 NLM ISO Abbreviation: Infect Dis (Lond) Subsets: MEDLINE

The Indispensable Value of Small-Molecule Antivirals in Epidemic and Pandemic Preparedness.

Authors: Draghia-Akli R Hill NM Altevogt B et al.

Source: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2026 Feb 09; Vol. 82 (1), pp. e49-e55.

Publication Type: Journal Article; Review

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE

Activating PKC-ε induces HIV expression with improved tolerability.

Authors: Irrinki AM Kaur J Randhawa B et al.

Source: PLoS pathogens [PLoS Pathog] 2025 Feb 06; Vol. 21 (2), pp. e1012874. Date of Electronic Publication: 2025 Feb 06 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses.

Authors: Martinez DR Moreira FR Catanzaro NJ et al.

Source: Science translational medicine [Sci Transl Med] 2024 May 22; Vol. 16 (748), pp. eadj4504. Date of Electronic Publication: 2024 May 22.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis.

Authors: Canales E Tse W Schroeder SD et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Oct 23; Vol. 68 (20), pp. 21072-21094. Date of Electronic Publication: 2025 Oct 01.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus.

Authors: Cross RW Woolsey C Chu VC et al.

Source: Science (New York, N.Y.) [Science] 2024 Mar 15; Vol. 383 (6688), pp. eadk6176. Date of Electronic Publication: 2024 Mar 15.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Perspectives on Advancing Countermeasures for Filovirus Disease: Report From a Multisector Meeting.

Authors: Sprecher A Cross R Marzi A et al.

Source: The Journal of infectious diseases [J Infect Dis] 2023 Nov 13; Vol. 228 (Suppl 7), pp. S474-S478.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE

Impact of HIV-1 capsid polymorphisms on viral infectivity and susceptibility to lenacapavir.

Authors: Hansen D Hendricks MR Chang S et al.

Source: MBio [mBio] 2025 May 14; Vol. 16 (5), pp. e0018725. Date of Electronic Publication: 2025 Apr 17.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

Remdesivir postexposure prophylaxis limits measles-induced "immune amnesia" and measles antibody responses in macaques.

Authors: Chan AKP Liu L Morgenlander WR et al.

Source: JCI insight [JCI Insight] 2025 Apr 22; Vol. 10 (11). Date of Electronic Publication: 2025 Apr 22 (Print Publication: 2025).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates.

Authors: Cross RW Woolsey C Prasad AN et al.

Source: Nature medicine [Nat Med] 2025 Apr; Vol. 31 (4), pp. 1303-1311. Date of Electronic Publication: 2025 Jan 13.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

The oral drug obeldesivir protects nonhuman primates against lethal Ebola virus infection.

Authors: Woolsey C Cross RW Chu VC et al.

Source: Science advances [Sci Adv] 2025 Mar 14; Vol. 11 (11), pp. eadw0659. Date of Electronic Publication: 2025 Mar 14.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

Antiviral target compound profile for pandemic preparedness.

Authors: Demarest JF Draghia-Akli R Cihlar T et al.

Corporate Authors: Demarest JF Draghia-Akli R Cihlar T et al.

Source: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2025 Feb; Vol. 24 (2), pp. 151-152.

Publication Type: Letter

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124171 Publication Model: Print Cited Medium: Internet ISSN: 1474-1784 (Electronic) Linking ISSN: 14741776 NLM ISO Abbreviation: Nat Rev Drug Discov Subsets: MEDLINE; In Process

A Randomized, Blinded, Vehicle-Controlled Dose-Ranging Study to Evaluate and Characterize Remdesivir Efficacy Against Ebola Virus in Rhesus Macaques.

Authors: Zumbrun EE Garvey CB Wells JB et al.

Source: Viruses [Viruses] 2024 Dec 18; Vol. 16 (12). Date of Electronic Publication: 2024 Dec 18.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.

Authors: Stevens LJ Pruijssers AJ Lee HW et al.

Source: Science translational medicine [Sci Transl Med] 2022 Aug 03; Vol. 14 (656), pp. eabo0718. Date of Electronic Publication: 2022 Aug 03.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2.

Authors: Feng JY Du Pont V Babusis D et al.

Source: Molecules (Basel, Switzerland) [Molecules] 2022 Jun 30; Vol. 27 (13). Date of Electronic Publication: 2022 Jun 30.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE