Search Results - "Colca JR"

Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice.

Authors: Strong R Nelson JF Bogue MA et al.

Source: GeroScience [Geroscience] 2026 Jun; Vol. 48 (3), pp. 4139-4156. Date of Electronic Publication: 2025 Sep 19.

Publication Type: Journal Article

Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE

Metabolic dysfunction and insulin sensitizers in acute and chronic disease.

Authors: Colca JR McCommis KS

Source: Expert opinion on investigational drugs [Expert Opin Investig Drugs] 2025 Jan-Feb; Vol. 34 (1-2), pp. 17-26. Date of Electronic Publication: 2025 Feb 07.

Publication Type: Journal Article; Review

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9434197 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-7658 (Electronic) Linking ISSN: 13543784 NLM ISO Abbreviation: Expert Opin Investig Drugs Subsets: MEDLINE

Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19.

Authors: Zhu B Wei X Narasimhan H et al.

Source: Science immunology [Sci Immunol] 2023 Apr 14; Vol. 8 (82), pp. eadf0348. Date of Electronic Publication: 2023 Apr 14.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE

Re-routing Metabolism by the Mitochondrial Pyruvate Carrier Inhibitor MSDC-0160 Attenuates Neurodegeneration in a Rat Model of Parkinson's Disease.

Authors: Mallet D Goutaudier R Barbier EL et al.

Source: Molecular neurobiology [Mol Neurobiol] 2022 Oct; Vol. 59 (10), pp. 6170-6182. Date of Electronic Publication: 2022 Jul 27.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Insulin sensitizers in 2023: lessons learned and new avenues for investigation.

Authors: Colca JR Tanis SP Kletzien RF et al.

Source: Expert opinion on investigational drugs [Expert Opin Investig Drugs] 2023 Jul-Dec; Vol. 32 (9), pp. 803-811. Date of Electronic Publication: 2023 Oct 13.

Publication Type: Journal Article; Review

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9434197 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-7658 (Electronic) Linking ISSN: 13543784 NLM ISO Abbreviation: Expert Opin Investig Drugs Subsets: MEDLINE

Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism.

Authors: Ferguson D Eichler SJ Yiew NKH et al.

Source: Molecular metabolism [Mol Metab] 2023 Apr; Vol. 70, pp. 101694. Date of Electronic Publication: 2023 Feb 18.

Publication Type: Randomized Controlled Trial; Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism.

Authors: Vigueira PA McCommis KS Hodges WT et al.

Source: Experimental physiology [Exp Physiol] 2017 Aug 01; Vol. 102 (8), pp. 985-999. Date of Electronic Publication: 2017 Jul 10.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9002940 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-445X (Electronic) Linking ISSN: 09580670 NLM ISO Abbreviation: Exp Physiol Subsets: MEDLINE

Metabolic Mechanisms Connecting Alzheimer's and Parkinson's Diseases: Potential Avenues for Novel Therapeutic Approaches.

Authors: Colca JR Finck BN

Source: Frontiers in molecular biosciences [Front Mol Biosci] 2022 Jun 16; Vol. 9, pp. 929328. Date of Electronic Publication: 2022 Jun 16 (Print Publication: 2022).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101653173 Publication Model: eCollection Cited Medium: Print ISSN: 2296-889X (Print) Linking ISSN: 2296889X NLM ISO Abbreviation: Front Mol Biosci Subsets: PubMed not MEDLINE

The metabolic syndrome, thiazolidinediones, and implications for intersection of chronic and inflammatory disease.

Authors: Colca JR Scherer PE

Source: Molecular metabolism [Mol Metab] 2022 Jan; Vol. 55, pp. 101409. Date of Electronic Publication: 2021 Dec 01.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Review

Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.

Authors: Ghosh A Tyson T George S et al.

Source: Science translational medicine [Sci Transl Med] 2016 Dec 07; Vol. 8 (368), pp. 368ra174.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide.

Authors: Kamm DR Pyles KD Sharpe MC et al.

Source: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100807. Date of Electronic Publication: 2021 May 20.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Suboptimal reliability of liver biopsy evaluation has implications for randomized clinical trials.

Authors: Davison BA Harrison SA Cotter G et al.

Source: Journal of hepatology [J Hepatol] 2020 Dec; Vol. 73 (6), pp. 1322-1332. Date of Electronic Publication: 2020 Jun 28.

Publication Type: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE

An insulin-sensitizing thiazolidinedione, which minimally activates PPARγ, does not cause bone loss.

Authors: Fukunaga T Zou W Rohatgi N et al.

Source: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 2015 Mar; Vol. 30 (3), pp. 481-8.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 8610640 Publication Model: Print Cited Medium: Internet ISSN: 1523-4681 (Electronic) Linking ISSN: 08840431 NLM ISO Abbreviation: J Bone Miner Res Subsets: MEDLINE

Mitochondrial target of thiazolidinediones.

Authors: Colca JR McDonald WG Kletzien RF

Source: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2014 Nov; Vol. 16 (11), pp. 1048-54. Date of Electronic Publication: 2014 May 22.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE

Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins.

Authors: Colca JR McDonald WG Cavey GS et al.

Source: PloS one [PLoS One] 2013 May 15; Vol. 8 (5), pp. e61551. Date of Electronic Publication: 2013 May 15 (Print Publication: 2013).

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets.

Authors: Rohatgi N Aly H Marshall CA et al.

Source: PloS one [PLoS One] 2013 May 01; Vol. 8 (5), pp. e62012. Date of Electronic Publication: 2013 May 01 (Print Publication: 2013).

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Clinical proof-of-concept study with MSDC-0160, a prototype mTOT-modulating insulin sensitizer.

Authors: Colca JR VanderLugt JT Adams WJ et al.

Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2013 Apr; Vol. 93 (4), pp. 352-9. Date of Electronic Publication: 2013 Jan 18.

Publication Type: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

Extend data exclusivity to save drug development.

Authors: Colca JR

Source: Science (New York, N.Y.) [Science] 2013 Jan 25; Vol. 339 (6118), pp. 393.

Publication Type: Letter; Comment

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study.

Authors: Harrison SA Alkhouri N Davison BA et al.

Source: Journal of hepatology [J Hepatol] 2020 Apr; Vol. 72 (4), pp. 613-626. Date of Electronic Publication: 2019 Nov 04.

Publication Type: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE

Inhibiting the mitochondrial pyruvate carrier does not ameliorate synucleinopathy in the absence of inflammation or metabolic deficits.

Authors: Peelaerts W Bergkvist L George S et al.

Source: Free neuropathology [Free Neuropathol] 2020; Vol. 1, pp. 33. Date of Electronic Publication: 2020 Nov 25.

Publication Type: Journal Article

Journal Info: Publisher: University of Muenster Country of Publication: Germany NLM ID: 101768755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2699-4445 (Electronic) Linking ISSN: 26994445 NLM ISO Abbreviation: Free Neuropathol Subsets: PubMed not MEDLINE