Search Results - "DRUG development"

Utilization of Healthy Volunteers in Oncology Drug Development in Japan: A 10-Year Analysis of Approved Anticancer Agents (2014-2024).

Authors: Morihisa K Yoshitsugu H Wakuda H et al.

Source: Clinical and translational science [Clin Transl Sci] 2026 Jun; Vol. 19 (6), pp. e70626.

Publication Type: Journal Article; Review

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

Tumor-Specific Success Probabilities and Factors Associated With Phase III Trials in Oncology Drug Development.

Authors: Yamamoto K Iwase A Maeda H

Source: Clinical and translational science [Clin Transl Sci] 2026 Jun; Vol. 19 (6), pp. e70635.

Publication Type: Journal Article

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

From Precision to Personalized: Catalyzing AI-Enabled Innovation in Drug Development.

Authors: Subbaswamy A Dunn A Langevin B et al.

Source: Clinical and translational science [Clin Transl Sci] 2026 Jun; Vol. 19 (6), pp. e70617.

Publication Type: Journal Article

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

Are we ready to replace animal models? A perspective on regulatory challenges of human-relevant drug testing systems.

Authors: Liu T Lu H

Source: Drug discoveries & therapeutics [Drug Discov Ther] 2026 Jul 14; Vol. 20 (3), pp. 205-210. Date of Electronic Publication: 2026 Jun 23.

Publication Type: Journal Article; Review

Journal Info: Publisher: Shandong University China-Japan Cooperation Center for Drug Discovery & Screen Country of Publication: Japan NLM ID: 101493809 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-784X (Electronic) Linking ISSN: 18817831 NLM ISO Abbreviation: Drug Discov Ther Subsets: MEDLINE

MIDD Evidence to Support Drug Regulatory Decisions in China.

Authors: Gao L Wang Y He R et al.

Source: Clinical and translational science [Clin Transl Sci] 2026 Jul; Vol. 19 (7), pp. e70656.

Publication Type: Journal Article; Review

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

Leveraging Mendelian randomization to inform drug discovery and development for ischemic stroke.

Authors: Daghlas I Gill D

Source: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2026 Jun; Vol. 46 (6), pp. 1404-1423. Date of Electronic Publication: 2024 Dec 04.

Publication Type: Journal Article; Review

Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 8112566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-7016 (Electronic) Linking ISSN: 0271678X NLM ISO Abbreviation: J Cereb Blood Flow Metab Subsets: MEDLINE

Quantitative Medicine to Support Drug Development and Regulatory Decisions: A UK Regulatory Approach Informed by ICH M15.

Authors: Kerwash E Butler AS Malamatari M et al.

Source: Clinical and translational science [Clin Transl Sci] 2026 Jun; Vol. 19 (6), pp. e70636.

Publication Type: Journal Article

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

Digital twins to accelerate target identification and drug development for immune-mediated disorders.

Authors: Niarakis A Moingeon P

Source: FEBS open bio [FEBS Open Bio] 2026 Jun; Vol. 16 (6), pp. 1048-1059. Date of Electronic Publication: 2026 Mar 23.

Publication Type: Journal Article; Review

Journal Info: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 101580716 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-5463 (Electronic) Linking ISSN: 22115463 NLM ISO Abbreviation: FEBS Open Bio Subsets: MEDLINE

Artificial Intelligence Across the Drug Development Lifecycle.

Authors: Demyashkin G Parshenkov M Zyryanov S et al.

Source: Medical sciences (Basel, Switzerland) [Med Sci (Basel)] 2026 May 10; Vol. 14 (2). Date of Electronic Publication: 2026 May 10.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629322 Publication Model: Electronic Cited Medium: Internet ISSN: 2076-3271 (Electronic) Linking ISSN: 20763271 NLM ISO Abbreviation: Med Sci (Basel) Subsets: MEDLINE

Supply and Demand in the Mathematics of Rare Disease Drug Development: Why Choosing the Right Model Is Crucial.

Authors: Summar ML Woodcock J

Source: Clinical and translational science [Clin Transl Sci] 2026 May; Vol. 19 (5), pp. e70551.

Publication Type: Journal Article; Review

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

From Models to Medicines: A Narrative History and Regulatory Perspective on the Translational Impact of Model-Informed Drug Development (MIDD).

Authors: Zineh I; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.

Source: Clinical and translational science [Clin Transl Sci] 2026 May; Vol. 19 (5), pp. e70547.

Publication Type: Journal Article; Historical Article; Review

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

Advancing Pharmacoequity in Low- and Middle-Income Countries via Model Informed Drug Development.

Authors: Enzama H Ojara FW Haworth IS et al.

Source: Clinical and translational science [Clin Transl Sci] 2026 May; Vol. 19 (5), pp. e70571.

Publication Type: Journal Article

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

Paediatric medicines development for Duchenne muscular dystrophy: An EU regulatory perspective.

Authors: Benchetrit S Chu C Athanasiou D et al.

Source: Journal of neuromuscular diseases [J Neuromuscul Dis] 2026 May; Vol. 13 (3), pp. 405-419. Date of Electronic Publication: 2025 Nov 18.

Publication Type: Journal Article; Review

Journal Info: Publisher: IOS Press Country of Publication: United States NLM ID: 101649948 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2214-3602 (Electronic) Linking ISSN: 22143599 NLM ISO Abbreviation: J Neuromuscul Dis Subsets: MEDLINE

Report of the multistakeholder drug development round table meeting of the World Duchenne Organization focusing on challenges for clinical development of therapies.

Authors: Aartsma-Rus A; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.

Source: Journal of neuromuscular diseases [J Neuromuscul Dis] 2026 Jul; Vol. 13 (4), pp. 850-859. Date of Electronic Publication: 2025 Dec 04.

Publication Type: Journal Article

Journal Info: Publisher: IOS Press Country of Publication: United States NLM ID: 101649948 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2214-3602 (Electronic) Linking ISSN: 22143599 NLM ISO Abbreviation: J Neuromuscul Dis Subsets: MEDLINE

Quality by design in public healthcare: a rapid development framework for future pandemics.

Authors: Panda N Maity M Kotra V et al.

Source: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques [J Pharm Pharm Sci] 2026 Jun 25; Vol. 29, pp. 16451. Date of Electronic Publication: 2026 Jun 25 (Print Publication: 2026).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 9807281 Publication Model: eCollection Cited Medium: Internet ISSN: 1482-1826 (Electronic) Linking ISSN: 14821826 NLM ISO Abbreviation: J Pharm Pharm Sci Subsets: MEDLINE

Drug response profile-based machine learning enables strategic cell line and compound selection for drug development.

Authors: Abdel-Rehim A Tate E Soldatova LN et al.

Source: Bioinformatics (Oxford, England) [Bioinformatics] 2026 Jun 01; Vol. 42 (6).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9808944 Publication Model: Print Cited Medium: Internet ISSN: 1367-4811 (Electronic) Linking ISSN: 13674803 NLM ISO Abbreviation: Bioinformatics Subsets: MEDLINE

Development Trends of Janus Kinase Inhibitors (JAKi) Over Three Decades: From Common to Rare Diseases.

Authors: Dai R Lou N Zheng X et al.

Source: Drug design, development and therapy [Drug Des Devel Ther] 2026 May 12; Vol. 20, pp. 597046. Date of Electronic Publication: 2026 May 12 (Print Publication: 2026).

Publication Type: Journal Article; Review

Journal Info: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE

Shifting a paradigm: highlights of model informed drug development in dosage selection and optimization for oncology products.

Authors: Xiong Y Konicki R Zirkelbach JF et al.

Source: The oncologist [Oncologist] 2026 May 08; Vol. 31 (6).

Publication Type: Journal Article; Review

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9607837 Publication Model: Print Cited Medium: Internet ISSN: 1549-490X (Electronic) Linking ISSN: 10837159 NLM ISO Abbreviation: Oncologist Subsets: MEDLINE

Clinical Pharmacology and Translational Science Considerations in the Development of Dual-Payload Antibody Drug Conjugates.

Authors: Ravenstijn P Kakinuma T Hamed S et al.

Source: Clinical and translational science [Clin Transl Sci] 2026 May; Vol. 19 (5), pp. e70569.

Publication Type: Journal Article; Review

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

Optimizing Oligonucleotide Therapeutics: A Model-Informed Drug Development Perspective.

Authors: Yuan Y Sharma V Bhattaram VA et al.

Source: Clinical and translational science [Clin Transl Sci] 2026 May; Vol. 19 (5), pp. e70570.

Publication Type: Journal Article; Review

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE