Search Results - "Dascal N"

Loss of expression and function of Gβγ by GNB1 encephalopathy-associated L95P mutation of the Gβ1 subunit.

Authors: Reddy HP Keren-Raifman T Tabak G et al.

Source: Frontiers in pharmacology [Front Pharmacol] 2025 May 09; Vol. 16, pp. 1592012. Date of Electronic Publication: 2025 May 09 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE

Ethosuximide: Subunit- and Gβγ-dependent blocker and reporter of allosteric changes in GIRK channels.

Authors: Shalomov B Friesacher T Yakubovich D et al.

Source: British journal of pharmacology [Br J Pharmacol] 2025 Apr; Vol. 182 (8), pp. 1704-1718. Date of Electronic Publication: 2025 Jan 15.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca²⁺ channel may modulate its β-adrenergic regulation.

Authors: Oz S Keren-Raifman T Sharon T et al.

Source: BMC biology [BMC Biol] 2024 Nov 28; Vol. 22 (1), pp. 276. Date of Electronic Publication: 2024 Nov 28.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190720 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7007 (Electronic) Linking ISSN: 17417007 NLM ISO Abbreviation: BMC Biol Subsets: MEDLINE

Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels.

Authors: Handklo-Jamal R Raifman TK Shalomov B et al.

Source: Nature communications [Nat Commun] 2025 Nov 24; Vol. 16 (1), pp. 11607. Date of Electronic Publication: 2025 Nov 24.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels.

Authors: Handklo-Jamal R Raifman TK Shalomov B et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Oct 15. Date of Electronic Publication: 2025 Oct 15.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

A revised mechanism of action of hyperaldosteronism-linked mutations in cytosolic domains of GIRK4 (KCNJ5).

Authors: Shalomov B Handklo-Jamal R Reddy HP et al.

Source: The Journal of physiology [J Physiol] 2022 Mar; Vol. 600 (6), pp. 1419-1437. Date of Electronic Publication: 2022 Jan 17.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 0266262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7793 (Electronic) Linking ISSN: 00223751 NLM ISO Abbreviation: J Physiol Subsets: MEDLINE

A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors.

Authors: Berlin S Artzy E Handklo-Jamal R et al.

Source: Frontiers in pharmacology [Front Pharmacol] 2020 Aug 12; Vol. 11, pp. 1216. Date of Electronic Publication: 2020 Aug 12 (Print Publication: 2020).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE

A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels.

Authors: Papa A Del Rivero Morfin PJ Chen BX et al.

Source: The Journal of clinical investigation [J Clin Invest] 2024 Jan 16; Vol. 134 (5). Date of Electronic Publication: 2024 Jan 16.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

Andersen-Tawil Syndrome Is Associated With Impaired PIP2 Regulation of the Potassium Channel Kir2.1.

Authors: Handklo-Jamal R Meisel E Yakubovich D et al.

Source: Frontiers in pharmacology [Front Pharmacol] 2020 May 15; Vol. 11, pp. 672. Date of Electronic Publication: 2020 May 15 (Print Publication: 2020).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE

Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor.

Authors: Colombo S Reddy HP Petri S et al.

Source: Frontiers in cellular neuroscience [Front Cell Neurosci] 2023 May 18; Vol. 17, pp. 1175895. Date of Electronic Publication: 2023 May 18 (Print Publication: 2023).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477935 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5102 (Print) Linking ISSN: 16625102 NLM ISO Abbreviation: Front Cell Neurosci Subsets: PubMed not MEDLINE

Protein kinase C enhances plasma membrane expression of cardiac L-type calcium channel, CaV1.2.

Authors: Raifman TK Kumar P Haase H et al.

Source: Channels (Austin, Tex.) [Channels (Austin)] 2017 Nov 02; Vol. 11 (6), pp. 604-615. Date of Electronic Publication: 2017 Sep 21.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101321614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-6969 (Electronic) Linking ISSN: 19336950 NLM ISO Abbreviation: Channels (Austin) Subsets: MEDLINE

Lithium reduces the span of G protein-activated K⁺ (GIRK) channel inhibition in hippocampal neurons.

Authors: Dascal N Rubinstein M

Source: Bipolar disorders [Bipolar Disord] 2017 Nov; Vol. 19 (7), pp. 568-574. Date of Electronic Publication: 2017 Sep 12.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Munksgaard Country of Publication: Denmark NLM ID: 100883596 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-5618 (Electronic) Linking ISSN: 13985647 NLM ISO Abbreviation: Bipolar Disord Subsets: MEDLINE

Collision coupling in the GABAB receptor-G protein-GIRK signaling cascade.

Authors: Kahanovitch U Berlin S Dascal N

Source: FEBS letters [FEBS Lett] 2017 Sep; Vol. 591 (18), pp. 2816-2825. Date of Electronic Publication: 2017 Aug 21.

Publication Type: Letter; Research Support, Non-U.S. Gov't

Journal Info: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3468 (Electronic) Linking ISSN: 00145793 NLM ISO Abbreviation: FEBS Lett Subsets: MEDLINE

A novel small-molecule selective activator of homomeric GIRK4 channels.

Authors: Cui M Xu K Gada KD et al.

Source: The Journal of biological chemistry [J Biol Chem] 2022 Jun; Vol. 298 (6), pp. 102009. Date of Electronic Publication: 2022 May 04.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

A selectivity filter mutation provides insights into gating regulation of a K⁺ channel.

Authors: Friesacher T Reddy HP Bernsteiner H et al.

Source: Communications biology [Commun Biol] 2022 Apr 11; Vol. 5 (1), pp. 345. Date of Electronic Publication: 2022 Apr 11.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels.

Authors: Reddy HP Yakubovich D Keren-Raifman T et al.

Source: IScience [iScience] 2021 Aug 21; Vol. 24 (9), pp. 103018. Date of Electronic Publication: 2021 Aug 21 (Print Publication: 2021).

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE

Protein kinase A regulates C-terminally truncated CaV 1.2 in Xenopus oocytes: roles of N- and C-termini of the α1C subunit.

Authors: Oz S Pankonien I Belkacemi A et al.

Source: The Journal of physiology [J Physiol] 2017 May 15; Vol. 595 (10), pp. 3181-3202. Date of Electronic Publication: 2017 Mar 23.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 0266262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7793 (Electronic) Linking ISSN: 00223751 NLM ISO Abbreviation: J Physiol Subsets: MEDLINE

Interactions between N and C termini of α1C subunit regulate inactivation of CaV1.2 L-type Ca(2+) channel.

Authors: Benmocha Guggenheimer A Almagor L Tsemakhovich V et al.

Source: Channels (Austin, Tex.) [Channels (Austin)] 2016; Vol. 10 (1), pp. 55-68.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101321614 Publication Model: Print Cited Medium: Internet ISSN: 1933-6969 (Electronic) Linking ISSN: 19336950 NLM ISO Abbreviation: Channels (Austin) Subsets: MEDLINE

A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ.

Authors: Yakubovich D Berlin S Kahanovitch U et al.

Source: PLoS computational biology [PLoS Comput Biol] 2015 Nov 06; Vol. 11 (11), pp. e1004598. Date of Electronic Publication: 2015 Nov 06 (Print Publication: 2015).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7358 (Electronic) Linking ISSN: 1553734X NLM ISO Abbreviation: PLoS Comput Biol Subsets: MEDLINE

Reconstitution of β-adrenergic regulation of CaV1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.

Authors: Katz M Subramaniam S Chomsky-Hecht O et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 May 25; Vol. 118 (21).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE