Search Results - "Deepa SS"

A Non-Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver.

Authors: Mohammed S Jiang C Pennington T et al.

Source: Aging cell [Aging Cell] 2026 Jul; Vol. 25 (7), pp. e70618.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE

A Narrative Review of Necroptosis in Neuromuscular Junction Disorders: Pathogenesis and Therapeutic Strategies.

Authors: Qaisar R Deepa SS

Source: Archives of medical research [Arch Med Res] 2026 Jul; Vol. 57 (5), pp. 103401. Date of Electronic Publication: 2026 Feb 13.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 9312706 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5487 (Electronic) Linking ISSN: 01884409 NLM ISO Abbreviation: Arch Med Res Subsets: MEDLINE

The role of inflammation induced by necroptosis in the development of fibrosis and liver cancer in novel knockin mouse models fed a western diet.

Authors: Selvarani R Nguyen HM Pazhanivel N et al.

Source: GeroScience [Geroscience] 2025 Jun; Vol. 47 (3), pp. 2973-2994. Date of Electronic Publication: 2024 Nov 08.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural

Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE

Impact of Mlkl or Ripk3 deletion on age-associated liver inflammation, metabolic health, and lifespan.

Authors: Mohammed S Ohene-Marfo P Jiang C et al.

Source: GeroScience [Geroscience] 2025 Jun; Vol. 47 (3), pp. 4465-4483. Date of Electronic Publication: 2025 Feb 10.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE

Hepatocyte MLKL Drives Obesity-Driven Hepatocellular Carcinoma Progression via Mitochondrial Dysfunction Independent of Necroptosis in MASLD.

Authors: Ohene-Marfo P Mohammed S Jiang C et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 30. Date of Electronic Publication: 2025 Nov 30.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Intracellular iron accumulation facilitates mycobacterial infection in old mouse macrophages.

Authors: Kotey SK Tan X Fleming O et al.

Source: GeroScience [Geroscience] 2024 Apr; Vol. 46 (2), pp. 2739-2754. Date of Electronic Publication: 2023 Dec 30.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE

Characterization of novel mouse models to study the role of necroptosis in aging and age-related diseases.

Authors: Selvarani R Van Michelle Nguyen H Thadathil N et al.

Source: GeroScience [Geroscience] 2023 Dec; Vol. 45 (6), pp. 3241-3256. Date of Electronic Publication: 2023 Oct 04.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE

A Non-canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver.

Authors: Mohammed S Jiang C Pennington T et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 May 03. Date of Electronic Publication: 2025 May 03.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma.

Authors: Thadathil N Selvarani R Mohammed S et al.

Source: Aging cell [Aging Cell] 2022 Aug; Vol. 21 (8), pp. e13676. Date of Electronic Publication: 2022 Jul 23.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE

Necroptosis contributes to chronic inflammation and fibrosis in aging liver.

Authors: Mohammed S Thadathil N Selvarani R et al.

Source: Aging cell [Aging Cell] 2021 Dec; Vol. 20 (12), pp. e13512. Date of Electronic Publication: 2021 Nov 11.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE

Necroptosis increases with age in the brain and contributes to age-related neuroinflammation.

Authors: Thadathil N Nicklas EH Mohammed S et al.

Source: GeroScience [Geroscience] 2021 Oct; Vol. 43 (5), pp. 2345-2361. Date of Electronic Publication: 2021 Sep 13.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE

MLKL overexpression leads to Ca²⁺ and metabolic dyshomeostasis in a neuronal cell model.

Authors: Deepa SS Thadathil N Corral J et al.

Source: Cell calcium [Cell Calcium] 2024 May; Vol. 119, pp. 102854. Date of Electronic Publication: 2024 Feb 06.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8006226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1991 (Electronic) Linking ISSN: 01434160 NLM ISO Abbreviation: Cell Calcium Subsets: MEDLINE

Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High-Fat, High-Fructose, High-Cholesterol Diet Mouse Model.

Authors: Ohene-Marfo P Nguyen HVM Mohammed S et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 28; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 28.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High Fat, High Fructose, High Cholesterol Diet Mouse Model.

Authors: Ohene-Marfo P Nguyen HVM Mohammed S et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 11. Date of Electronic Publication: 2024 Jan 11.

Publication Type: Preprint; Journal Article

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis.

Authors: Mohammed S Thadathil N Ohene-Marfo P et al.

Source: Molecular cancer research : MCR [Mol Cancer Res] 2023 Sep 01; Vol. 21 (9), pp. 933-946.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101150042 Publication Model: Print Cited Medium: Internet ISSN: 1557-3125 (Electronic) Linking ISSN: 15417786 NLM ISO Abbreviation: Mol Cancer Res Subsets: MEDLINE

The potential role of necroptosis in inflammaging and aging.

Authors: Royce GH Brown-Borg HM Deepa SS

Source: GeroScience [Geroscience] 2019 Dec; Vol. 41 (6), pp. 795-811. Date of Electronic Publication: 2019 Nov 13.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Review

Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE

Accelerated decline in cognition in a mouse model of increased oxidative stress.

Authors: Logan S Royce GH Owen D et al.

Source: GeroScience [Geroscience] 2019 Oct; Vol. 41 (5), pp. 591-607. Date of Electronic Publication: 2019 Oct 22.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE

Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis.

Authors: Bhaskaran S Kumar G Thadathil N et al.

Source: Redox biology [Redox Biol] 2023 Feb; Vol. 59, pp. 102550. Date of Electronic Publication: 2022 Nov 26.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE

Necroptosis increases with age and is reduced by dietary restriction.

Authors: Deepa SS Unnikrishnan A Matyi S et al.

Source: Aging cell [Aging Cell] 2018 Aug; Vol. 17 (4), pp. e12770. Date of Electronic Publication: 2018 Apr 25.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE

Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice.

Authors: Deepa SS Pharaoh G Kinter M et al.

Source: Aging cell [Aging Cell] 2018 Aug; Vol. 17 (4), pp. e12769. Date of Electronic Publication: 2018 Apr 25.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE