Search Results - "Demarest KT"

Phase 0 study of the inhibition of cholesteryl ester transfer protein activity by JNJ-28545595 in plasma from normolipidemic and dyslipidemic humans.

Authors: Sarich TC Connelly MA Schranz DB et al.

Source: International journal of clinical pharmacology and therapeutics [Int J Clin Pharmacol Ther] 2012 Aug; Vol. 50 (8), pp. 584-94.

Publication Type: Journal Article; Validation Study

Journal Info: Publisher: Dustri-Verlag Dr. K. Feistle Country of Publication: Germany NLM ID: 9423309 Publication Model: Print Cited Medium: Print ISSN: 0946-1965 (Print) Linking ISSN: 09461965 NLM ISO Abbreviation: Int J Clin Pharmacol Ther Subsets: MEDLINE

Beneficial metabolic effects of CB1R anti-sense oligonucleotide treatment in diet-induced obese AKR/J mice.

Authors: Tang Y Ho G Li Y et al.

Source: PloS one [PLoS One] 2012; Vol. 7 (8), pp. e42134. Date of Electronic Publication: 2012 Aug 03.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Characterization of RWJ-351647, a novel nonpeptide vasopressin V2 receptor antagonist.

Authors: Gunnet JW Matthews JM Maryanoff BE et al.

Source: Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2006 Apr; Vol. 33 (4), pp. 320-6.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: Australia NLM ID: 0425076 Publication Model: Print Cited Medium: Print ISSN: 0305-1870 (Print) Linking ISSN: 03051870 NLM ISO Abbreviation: Clin Exp Pharmacol Physiol Subsets: MEDLINE

Sustained aquaretic effect of the V2-AVP receptor antagonist, RWJ-351647, in cirrhotic rats with ascites and water retention.

Authors: Ros J Fernández-Varo G Muñoz-Luque J et al.

Source: British journal of pharmacology [Br J Pharmacol] 2005 Nov; Vol. 146 (5), pp. 654-61.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print Cited Medium: Print ISSN: 0007-1188 (Print) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Pharmacological profile of a novel, non-TZD PPARgamma agonist.

Authors: Chen X Osborne MC Rybczynski PJ et al.

Source: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2005 Sep; Vol. 7 (5), pp. 536-46.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print Cited Medium: Print ISSN: 1462-8902 (Print) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE

Topiramate is an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF rats.

Authors: Wilkes JJ Nelson E Osborne M et al.

Source: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2005 Mar; Vol. 288 (3), pp. E617-24. Date of Electronic Publication: 2004 Nov 09.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0193-1849 (Print) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE

Distinctive and synergistic signaling of human adenosine A2a and dopamine D2L receptors in CHO cells.

Authors: Tang Y Demarest KT

Source: Journal of receptor and signal transduction research [J Recept Signal Transduct Res] 2005; Vol. 25 (3), pp. 159-79.

Publication Type: Journal Article

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9509432 Publication Model: Print Cited Medium: Print ISSN: 1079-9893 (Print) Linking ISSN: 10799893 NLM ISO Abbreviation: J Recept Signal Transduct Res Subsets: MEDLINE

Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice.

Authors: Liang Y Osborne MC Monia BP et al.

Source: Diabetes [Diabetes] 2004 Feb; Vol. 53 (2), pp. 410-7.

Publication Type: Journal Article

Journal Info: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print Cited Medium: Print ISSN: 0012-1797 (Print) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE

The use of biosensors to study GPCR function: applications for high-content screening.

Authors: Conway BR Demarest KT

Source: Receptors & channels [Recept Channels] 2002; Vol. 8 (5-6), pp. 331-41.

Publication Type: Journal Article; Review

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9315376 Publication Model: Print Cited Medium: Print ISSN: 1060-6823 (Print) Linking ISSN: 10606823 NLM ISO Abbreviation: Recept Channels Subsets: MEDLINE

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs.

Authors: Yang SM Tang Y Rano T et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Mar 01; Vol. 24 (5), pp. 1437-41. Date of Electronic Publication: 2013 Dec 27.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs.

Authors: Yang SM Tang Y Zhang R et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Dec 15; Vol. 23 (24), pp. 6773-6. Date of Electronic Publication: 2013 Oct 09.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2.

Authors: Qi J Lang W Geisler JG et al.

Source: Journal of lipid research [J Lipid Res] 2012 Jun; Vol. 53 (6), pp. 1106-16. Date of Electronic Publication: 2012 Apr 03.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0376606 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-7262 (Electronic) Linking ISSN: 00222275 NLM ISO Abbreviation: J Lipid Res Subsets: MEDLINE

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.

Authors: Semple G Ren A Fioravanti B et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 May 15; Vol. 21 (10), pp. 3134-41. Date of Electronic Publication: 2011 Mar 13.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition.

Authors: Connelly MA Parry TJ Giardino EC et al.

Source: Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 2010 May; Vol. 55 (5), pp. 459-68.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7902492 Publication Model: Print Cited Medium: Internet ISSN: 1533-4023 (Electronic) Linking ISSN: 01602446 NLM ISO Abbreviation: J Cardiovasc Pharmacol Subsets: MEDLINE

Synthesis and discovery of 2,3-dihydro-3,8-diphenylbenzo[1,4]oxazines as a novel class of potent cholesteryl ester transfer protein inhibitors.

Authors: Wang A Prouty CP Pelton PD et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Feb 15; Vol. 20 (4), pp. 1432-5. Date of Electronic Publication: 2010 Jan 04.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform.

Authors: Rano TA Sieber-McMaster E Pelton PD et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 May 01; Vol. 19 (9), pp. 2456-60. Date of Electronic Publication: 2009 Mar 18.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Design, synthesis, and biological evaluation of (2R,alphaS)-3,4-dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-alpha-(trifluoromethyl)-1(2H)-quinolineethanol as potent and orally active cholesteryl ester transfer protein inhibitor.

Authors: Kuo GH Rano T Pelton P et al.

Source: Journal of medicinal chemistry [J Med Chem] 2009 Mar 26; Vol. 52 (6), pp. 1768-72.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Pharmacological characterization of RWJ-676070, a dual vasopressin V(1A)/V(2) receptor antagonist.

Authors: Gunnet JW Wines P Xiang M et al.

Source: European journal of pharmacology [Eur J Pharmacol] 2008 Aug 20; Vol. 590 (1-3), pp. 333-42. Date of Electronic Publication: 2008 Jun 07.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0014-2999 (Print) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists.

Authors: Matthews JM Chen X Cryan E et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Dec 15; Vol. 17 (24), pp. 6773-8. Date of Electronic Publication: 2007 Oct 17.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies.

Authors: Xiang MA Rybczynski PJ Patel M et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Dec 01; Vol. 17 (23), pp. 6623-8. Date of Electronic Publication: 2007 Sep 19.

Publication Type: Comparative Study; Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE