Search Results - "Diffley JFX"

Targeting cancer-specific mutations with RNA-triggered chromatin shredding.

Authors: Zeng J Cheng Z Chen H et al.

Source: Nature [Nature] 2026 Aug; Vol. 656 (8126), pp. 199-206. Date of Electronic Publication: 2026 Jun 08.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

Structure of the pre-initiation complex explains CMGE biogenesis.

Authors: Pühringer T Canal B Palm G et al.

Source: Nature [Nature] 2026 Jul; Vol. 655 (8125), pp. 1330-1338. Date of Electronic Publication: 2026 Jun 17.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

S-phase checkpoint protects from aberrant replication fork processing and degradation.

Authors: Núñez-Martín I Drury LS Martínez-Jiménez MI et al.

Source: Nucleic acids research [Nucleic Acids Res] 2025 Jul 19; Vol. 53 (14).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Selective Elimination of TP53 Mutant Cells by Transcript-Activated Chromatin Shredding.

Authors: Zeng J Cheng Z Chen H et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 09. Date of Electronic Publication: 2026 May 09.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Replisome passage through the cohesin ring.

Authors: Glaser S Molodtsov MI Diffley JFX et al.

Source: Cell [Cell] 2025 Oct 02; Vol. 188 (20), pp. 5618-5631.e14. Date of Electronic Publication: 2025 Sep 16.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication.

Authors: Minamino M Diffley JFX Uhlmann F

Source: Molecular cell [Mol Cell] 2025 Oct 02; Vol. 85 (19), pp. 3576-3587.e6. Date of Electronic Publication: 2025 Sep 16.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

Cell cycle regulation has shaped replication origins in budding yeast.

Authors: Lim CT Miller TCR Tan KW et al.

Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2025 Sep; Vol. 32 (9), pp. 1697-1707. Date of Electronic Publication: 2025 Jun 30.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells.

Authors: Bertolin AP Canal B Yekezare M et al.

Source: Molecular cell [Mol Cell] 2025 Jul 03; Vol. 85 (13), pp. 2474-2486.e6. Date of Electronic Publication: 2025 Jun 26.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

The DNA replication checkpoint limits Okazaki fragment accumulation to protect and restart stalled forks.

Authors: Canal B Bertolin AP Lee GC et al.

Source: Molecular cell [Mol Cell] 2025 Jul 03; Vol. 85 (13), pp. 2462-2473.e6. Date of Electronic Publication: 2025 Jun 26.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

Mechanisms for licensing origins of DNA replication in eukaryotic cells.

Authors: Stillman B Diffley JFX Iwasa JH

Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2025 Jul; Vol. 32 (7), pp. 1143-1153. Date of Electronic Publication: 2025 Jun 30.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

A chromatinized origin reduces the mobility of ORC and MCM through interactions and spatial constraint.

Authors: Sánchez H Liu Z van Veen E et al.

Source: Nature communications [Nat Commun] 2023 Oct 23; Vol. 14 (1), pp. 6735. Date of Electronic Publication: 2023 Oct 23.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation.

Authors: Ramírez Montero D Sánchez H van Veen E et al.

Source: Nature communications [Nat Commun] 2023 Apr 14; Vol. 14 (1), pp. 2082. Date of Electronic Publication: 2023 Apr 14.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MCM double hexamer loading visualized with human proteins.

Authors: Weissmann F Greiwe JF Pühringer T et al.

Source: Nature [Nature] 2024 Dec; Vol. 636 (8042), pp. 499-508. Date of Electronic Publication: 2024 Nov 27.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

Author Correction: Unwinding of a eukaryotic origin of replication visualized by cryo-EM.

Authors: Henrikus SS Gross MH Willhoft O et al.

Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2024 Nov; Vol. 31 (11), pp. 1808.

Publication Type: Published Erratum

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE; PubMed not MEDLINE

Unwinding of a eukaryotic origin of replication visualized by cryo-EM.

Authors: Henrikus SS Gross MH Willhoft O et al.

Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2024 Aug; Vol. 31 (8), pp. 1265-1276. Date of Electronic Publication: 2024 May 17.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

Hybrid Ensemble and Single-molecule Assay to Image the Motion of Fully Reconstituted CMG.

Authors: Ramírez Montero D Sánchez H van Veen E et al.

Source: Journal of visualized experiments : JoVE [J Vis Exp] 2024 Jul 26 (209). Date of Electronic Publication: 2024 Jul 26.

Publication Type: Journal Article; Video-Audio Media; Research Support, Non-U.S. Gov't

Journal Info: Publisher: MYJoVE Corporation Country of Publication: United States NLM ID: 101313252 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-087X (Electronic) Linking ISSN: 1940087X NLM ISO Abbreviation: J Vis Exp Subsets: MEDLINE

Author's overview: identifying SARS-CoV-2 antiviral compounds.

Authors: Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.

Source: The Biochemical journal [Biochem J] 2021 Jul 16; Vol. 478 (13), pp. 2533-2535.

Publication Type: Journal Article; Review

Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase.

Authors: Bertolin AP Weissmann F Zeng J et al.

Source: The Biochemical journal [Biochem J] 2021 Jul 16; Vol. 478 (13), pp. 2425-2443.

Publication Type: Journal Article

Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease.

Authors: Canal B McClure AW Curran JF et al.

Source: The Biochemical journal [Biochem J] 2021 Jul 16; Vol. 478 (13), pp. 2445-2464.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease.

Authors: Canal B Fujisawa R McClure AW et al.

Source: The Biochemical journal [Biochem J] 2021 Jul 16; Vol. 478 (13), pp. 2465-2479.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE