Search Results - "Edink E"

Pyrazolo[5,1- c ][1,2,4]triazole: A Promising Emerging Biologically Active Scaffold in Medicinal Chemistry.

Authors: Pintea, Beniamin-Nicolae Panțîr, Vasilica-Georgiana Badea, Valentin et al.

Source: International Journal of Molecular Sciences. Sep2025, Vol. 26 Issue 17, p8190. 26p.

To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A?

Authors: Zheng, Yang Schroeder, Susanne Kanev, Georgi K. et al.

Source: International Journal of Molecular Sciences. Apr2023, Vol. 24 Issue 7, p6817. 18p.

Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages.

Authors: Munday, Jane C. Kunz, Stefan Kalejaiye, Titilola D. et al.

Source: PLoS Neglected Tropical Diseases. 7/30/2020, Vol. 14 Issue 7, p1-29. 29p.

From recipe to research: introducing undergraduate students to the nature of science using a hybrid practical course centred on drug discovery for neglected diseases.

Authors: Wijtmans M Edink E van Linden OP et al.

Source: Drug discovery today [Drug Discov Today] 2021 Jun; Vol. 26 (6), pp. 1359-1368. Date of Electronic Publication: 2021 Feb 18.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9604391 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5832 (Electronic) Linking ISSN: 13596446 NLM ISO Abbreviation: Drug Discov Today Subsets: MEDLINE

Discovery of Diaryl Ether Substituted Tetrahydrophthalazinones as TbrPDEB1 Inhibitors Following Structure-Based Virtual Screening.

Authors: de Heuvel E Kooistra AJ Edink E et al.

Source: Frontiers in chemistry [Front Chem] 2021 Jan 21; Vol. 8, pp. 608030. Date of Electronic Publication: 2021 Jan 21 (Print Publication: 2020).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101627988 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2646 (Print) Linking ISSN: 22962646 NLM ISO Abbreviation: Front Chem Subsets: PubMed not MEDLINE

Developments and challenges in hit progression within fragment-based drug discovery.

Authors: Grosjean H Biggin PC

Source: Nature communications [Nat Commun] 2026 Jan 31; Vol. 17 (1). Date of Electronic Publication: 2026 Jan 31.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Exploring a New Generation of Pyrimidine and Pyridine Derivatives as Anti-Influenza Agents Targeting the Polymerase PA–PB1 Subunits Interaction.

Authors: Giacchello, Ilaria Cianciusi, Annarita Bertagnin, Chiara et al.

Source: Pharmaceutics. Jul2024, Vol. 16 Issue 7, p954. 25p.

Acetylcholine-Binding Protein Affinity Profiling of Neurotoxins in Snake Venoms with Parallel Toxin Identification.

Authors: Palermo, Giulia Schouten, Wietse M. Alonso, Luis Lago et al.

Source: International Journal of Molecular Sciences. Dec2023, Vol. 24 Issue 23, p16769. 18p.

Tackling Sleeping Sickness: Current and Promising Therapeutics and Treatment Strategies.

Authors: Jamabo, Miebaka Mahlalela, Maduma Edkins, Adrienne L. et al.

Source: International Journal of Molecular Sciences. Aug2023, Vol. 24 Issue 15, p12529. 30p.

Green Drug Discovery: Novel Fragment Space from the Biomass-Derived Molecule Dihydrolevoglucosenone (Cyrene TM).

Authors: Dekker, Tom Harteveld, Jaap W. Wágner, Gábor et al.

Source: Molecules. Feb2023, Vol. 28 Issue 4, p1777. 19p.

Forces Driving a Magic Bullet to Its Target: Revisiting the Role of Thermodynamics in Drug Design, Development, and Optimization.

Authors: Minetti, Conceição A. Remeta, David P.

Source: Life (2075-1729). Sep2022, Vol. 12 Issue 9, p1438-N.PAG. 42p.

Design, Synthesis, Molecular Docking Analysis and Biological Evaluations of 4-[(Quinolin-4-yl)amino]benzamide Derivatives as Novel Anti-Influenza Virus Agents.

Authors: Zhang, Chao Tang, Yun-Sang Meng, Chu-Ren et al.

Source: International Journal of Molecular Sciences. Jun2022, Vol. 23 Issue 11, p6307-6307. 30p.

Fragment-Based Drug Discovery for Trypanosoma brucei Glycosylphosphatidylinositol-Specific Phospholipase C through Biochemical and WaterLOGSY-NMR Methods.

Authors: Ibrahim, Mohammed Auwal Yamasaki, Tomoko Furukawa, Koji et al.

Source: Journal of Biochemistry. Jun2022, Vol. 171 Issue 6, p619-629. 11p.

Recent Trends of Polymer-Protein Conjugate Application in Biocatalysis: A Review.

Authors: Basak, Souvik Punetha, Vinay Deep Bisht, Ganga et al.

Source: Polymer Reviews. 2015, Vol. 55 Issue 1, p163-198. 36p.

Preparation and Properties of Thermoresponsive Bioconjugates of Trypsin.

Authors: Raghava, Smita Mondal, Kalyani Gupta, Munishwar N. et al.

Source: Artificial Cells, Blood Substitutes & Biotechnology. May/Jun2006, Vol. 34 Issue 3, p323-336. 14p.

Understanding structure-function relationships of the human neuronal acetylcholine receptor: insights from the first crystal structures of neuronal subunits.

Authors: Giastas, Petros Zouridakis, Marios Tzartos, Socrates J

Source: British Journal of Pharmacology. Jun2018, Vol. 175 Issue 11, p1880-1891. 12p. 6 Diagrams.

Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine-Binding Protein as a Structural Surrogate.

Authors: Shahsavar, Azadeh Gajhede, Michael Kastrup, Jette S. et al.

Source: Basic & Clinical Pharmacology & Toxicology. Jun2016, Vol. 118 Issue 6, p399-407. 9p.

Predicting Allosteric Effects from Orthosteric Binding in Hsp90-Ligand Interactions: Implications for Fragment-Based Drug Design.

Authors: Chandramohan, Arun Krishnamurthy, Srinath Larsson, Andreas et al.

Source: PLoS Computational Biology. 6/2/2016, Vol. 12 Issue 6, p1-17. 17p.

Evaluation of Various Solvent Extracts of Tetrastigma leucostaphylum (Dennst.) Alston Leaves, a Bangladeshi Traditional Medicine Used for the Treatment of Diarrhea.

Authors: Rudra, Sajib Tahamina, Afroza Emon, Nazim Uddin et al.

Source: Molecules. Nov2020, Vol. 25 Issue 21, p4994. 1p.

A Structural Model of the Human α7 Nicotinic Receptor in an Open Conformation.

Authors: Chiodo, Letizia Malliavin, Thérèse E. Maragliano, Luca et al.

Source: PLoS ONE. 7/24/2015, Vol. 10 Issue 7, p1-30. 30p.