Search Results - "Ellsworth BA"

Identification and Studies of Highly Potent and Selective Heterobifunctional Galectin‑3 Degraders.

Authors: Liu C Wang W Balog AJ et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2026 Jul 31; Vol. 17 (8), pp. 1864-1872. Date of Electronic Publication: 2026 Jul 31 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Discovery of Triazine-Based Toll-Like Receptor 9 Antagonists with Oral Activity.

Authors: Mandler MD Zhu Y Hollenbeck EC et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2026 Feb 27; Vol. 17 (3), pp. 727-732. Date of Electronic Publication: 2026 Feb 27 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Discovery of Potent and Selective Reversible Ubiquitin-Like Modifier Activating Enzyme 5 Inhibitors Targeting the UFMylation Pathway.

Authors: Mignone JJ Jurica EA Rajasekaran D et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Oct 09; Vol. 68 (19), pp. 20827-20845. Date of Electronic Publication: 2025 Sep 25.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Atropisomerism Observed in Galactose-Based Monosaccharide Inhibitors of Galectin-3 Comprising 2-Methyl-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione.

Authors: Yoon DS Liu C Jalagam PR et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14184-14199. Date of Electronic Publication: 2024 Aug 05.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Identification of benzothiazole derived monosaccharides as potent, selective, and orally bioavailable inhibitors of human and mouse galectin-3; a rare example of using a S···O binding interaction for drug design.

Authors: Liu C Wang W Feng J et al.

Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Mar 01; Vol. 101, pp. 117638. Date of Electronic Publication: 2024 Feb 11.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

Synthesis of Bicyclo[1.1.0]butanes from Iodo-Bicyclo[1.1.1]pentanes.

Authors: Mandler MD Mignone J Jurica EA et al.

Source: Organic letters [Org Lett] 2023 Nov 10; Vol. 25 (44), pp. 7947-7952. Date of Electronic Publication: 2023 Jun 07.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE; PubMed not MEDLINE

Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities.

Authors: Jurica EA Wu X Williams KN et al.

Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2023 May 01; Vol. 85, pp. 117273. Date of Electronic Publication: 2023 Apr 04.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

Amination of Nitro-Substituted Heteroarenes by Nucleophilic Substitution of Hydrogen.

Authors: Mandler MD Suss N Ramirez A et al.

Source: Organic letters [Org Lett] 2022 Oct 21; Vol. 24 (41), pp. 7643-7648. Date of Electronic Publication: 2022 Oct 10.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE; PubMed not MEDLINE

Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3.

Authors: Liu C Jalagam PR Feng J et al.

Source: Journal of medicinal chemistry [J Med Chem] 2022 Aug 25; Vol. 65 (16), pp. 11084-11099. Date of Electronic Publication: 2022 Aug 15.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis.

Authors: Nara SJ Jogi S Cheruku S et al.

Source: Journal of medicinal chemistry [J Med Chem] 2022 Jul 14; Vol. 65 (13), pp. 8948-8960. Date of Electronic Publication: 2022 Jun 15.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Structural and Thermal Characterization of Halogenated Azidopyridines: Under-Reported Synthons for Medicinal Chemistry.

Authors: Mandler MD Degnan AP Zhang S et al.

Source: Organic letters [Org Lett] 2022 Jan 28; Vol. 24 (3), pp. 799-803. Date of Electronic Publication: 2021 Oct 29.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett

Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases.

Authors: Cheng PTW Kaltenbach RF 3rd Zhang H et al.

Source: Journal of medicinal chemistry [J Med Chem] 2021 Nov 11; Vol. 64 (21), pp. 15549-15581. Date of Electronic Publication: 2021 Oct 28.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis.

Authors: Carpenter J Wu G Wang Y et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Aug 05; Vol. 12 (9), pp. 1413-1420. Date of Electronic Publication: 2021 Aug 05 (Print Publication: 2021).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors.

Authors: Xu L Hartz RA Beno BR et al.

Source: Journal of medicinal chemistry [J Med Chem] 2021 May 27; Vol. 64 (10), pp. 6634-6655. Date of Electronic Publication: 2021 May 14.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Adjunctive renal sympathetic denervation to modify hypertension as upstream therapy in the treatment of atrial fibrillation (H-FIB) study: clinical background and study design.

Authors: Ahmed H Miller MA Dukkipati SR et al.

Source: Journal of cardiovascular electrophysiology [J Cardiovasc Electrophysiol] 2013 May; Vol. 24 (5), pp. 503-9. Date of Electronic Publication: 2013 Feb 19.

Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial

Journal Info: Publisher: Blackwell Country of Publication: United States NLM ID: 9010756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8167 (Electronic) Linking ISSN: 10453873 NLM ISO Abbreviation: J Cardiovasc Electrophysiol Subsets: MEDLINE

Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists.

Authors: Shi J Gu Z Jurica EA et al.

Source: Journal of medicinal chemistry [J Med Chem] 2018 Feb 08; Vol. 61 (3), pp. 681-694. Date of Electronic Publication: 2018 Jan 27.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode.

Authors: Jurica EA Wu X Williams KN et al.

Source: Journal of medicinal chemistry [J Med Chem] 2017 Feb 23; Vol. 60 (4), pp. 1417-1431. Date of Electronic Publication: 2017 Feb 09.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties.

Authors: Ellsworth BA Sher PM Wu X et al.

Source: Journal of medicinal chemistry [J Med Chem] 2013 Dec 12; Vol. 56 (23), pp. 9586-600. Date of Electronic Publication: 2013 Nov 20.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Preparation of N-alkyl 2-pyridones via a lithium iodide promoted O- to N-alkyl migration: scope and mechanism.

Authors: Tasker SZ Bosscher MA Shandro CA et al.

Source: The Journal of organic chemistry [J Org Chem] 2012 Sep 21; Vol. 77 (18), pp. 8220-30. Date of Electronic Publication: 2012 Sep 12.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE

Cannabinoid CB(1) receptor ligand binding and function examined through mutagenesis studies of F200 and S383.

Authors: Sitkoff DF Lee N Ellsworth BA et al.

Source: European journal of pharmacology [Eur J Pharmacol] 2011 Jan 25; Vol. 651 (1-3), pp. 9-17. Date of Electronic Publication: 2010 Oct 31.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE