Search Results - "Epemolu O"

194 - Targeting drug resistance mutations: Discovery of EUD-GK-91 chemical series.

Authors: Zuccotto, F. Angiolini, M. Bernardi, A. et al.

Source: European Journal of Cancer. Dec2016 Supplement 1, Vol. 69, pS68-S68. 1p.

Design and Development of Lysyl tRNA Synthetase Inhibitors, for the Treatment of Tuberculosis.

Authors: Davis SH Mathieson M Buchanan KI et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Aug 14; Vol. 68 (15), pp. 16459-16482. Date of Electronic Publication: 2025 Aug 01.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Identification of a Series Containing a Pentafluorophenyl Moiety That Targets Pks13 to Inhibit Growth of Mycobacterium tuberculosis.

Authors: Green SR Harrison JR Thompson S et al.

Source: ACS infectious diseases [ACS Infect Dis] 2025 Mar 14; Vol. 11 (3), pp. 715-726. Date of Electronic Publication: 2025 Feb 27.

Publication Type: Journal Article

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.

Authors: Green SR Davis SH Damerow S et al.

Source: Nature communications [Nat Commun] 2022 Oct 11; Vol. 13 (1), pp. 5992. Date of Electronic Publication: 2022 Oct 11.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Anti-Inflammatory Effects of Auranamide and Patriscabratine-Mechanisms and In Silico Studies.

Authors: Mak KK Shiming Z Low JS et al.

Source: Molecules (Basel, Switzerland) [Molecules] 2022 Aug 05; Vol. 27 (15). Date of Electronic Publication: 2022 Aug 05.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market.

Authors: Brandon AM Antonides LH Riley J et al.

Source: Molecules (Basel, Switzerland) [Molecules] 2021 Mar 05; Vol. 26 (5). Date of Electronic Publication: 2021 Mar 05.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity.

Authors: Green SR Wilson C Eadsforth TC et al.

Source: Journal of medicinal chemistry [J Med Chem] 2023 Nov 23; Vol. 66 (22), pp. 15380-15408. Date of Electronic Publication: 2023 Nov 10.

Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Swietenine Alleviates Nonalcoholic Fatty Liver Disease in Diabetic Mice via Lipogenesis Inhibition and Antioxidant Mechanisms.

Authors: Mak KK Zhang S Chellian J et al.

Source: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2023 Feb 27; Vol. 12 (3). Date of Electronic Publication: 2023 Feb 27.

Publication Type: Journal Article

Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101668981 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3921 (Print) Linking ISSN: 20763921 NLM ISO Abbreviation: Antioxidants (Basel) Subsets: PubMed not MEDLINE

Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability.

Authors: Mak KK Shiming Z Sakirolla R et al.

Source: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2023 Feb 13; Vol. 12 (2). Date of Electronic Publication: 2023 Feb 13.

Publication Type: Journal Article

Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101668981 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3921 (Print) Linking ISSN: 20763921 NLM ISO Abbreviation: Antioxidants (Basel) Subsets: PubMed not MEDLINE

Synthesis and Anti-Inflammatory Activity of 2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophene-Derived NRF2 Activators.

Authors: Mak KK Shiming Z Epemolu O et al.

Source: ChemistryOpen [ChemistryOpen] 2022 Oct; Vol. 11 (10), pp. e202200181.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 101594811 Publication Model: Print Cited Medium: Internet ISSN: 2191-1363 (Electronic) Linking ISSN: 21911363 NLM ISO Abbreviation: ChemistryOpen Subsets: MEDLINE

The role of DMPK science in improving pharmaceutical research and development efficiency.

Authors: Mak KK Epemolu O Pichika MR

Source: Drug discovery today [Drug Discov Today] 2022 Mar; Vol. 27 (3), pp. 705-729. Date of Electronic Publication: 2021 Nov 10.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9604391 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5832 (Electronic) Linking ISSN: 13596446 NLM ISO Abbreviation: Drug Discov Today Subsets: MEDLINE

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.

Authors: Wilson C Ray P Zuccotto F et al.

Source: Journal of medicinal chemistry [J Med Chem] 2022 Jan 13; Vol. 65 (1), pp. 409-423. Date of Electronic Publication: 2021 Dec 15.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition.

Authors: Frost J Galdeano C Soares P et al.

Source: Nature communications [Nat Commun] 2016 Nov 04; Vol. 7, pp. 13312. Date of Electronic Publication: 2016 Nov 04.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth.

Authors: Ray PC Huggett M Turner PA et al.

Source: ACS omega [ACS Omega] 2021 Jan 13; Vol. 6 (3), pp. 2284-2311. Date of Electronic Publication: 2021 Jan 13 (Print Publication: 2021).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE

Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity.

Authors: Thomas MG De Rycker M Wall RJ et al.

Source: Journal of medicinal chemistry [J Med Chem] 2020 Sep 10; Vol. 63 (17), pp. 9523-9539. Date of Electronic Publication: 2020 Aug 13.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1).

Authors: Bell M Foley D Naylor C et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 Feb 14; Vol. 10 (3), pp. 341-347. Date of Electronic Publication: 2019 Feb 14 (Print Publication: 2019).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1.

Authors: Bell M Foley D Naylor C et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Oct 15; Vol. 28 (19), pp. 3255-3259. Date of Electronic Publication: 2018 Jul 30.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future.

Authors: Smith PW Zuccotto F Bates RH et al.

Source: ACS infectious diseases [ACS Infect Dis] 2018 Oct 12; Vol. 4 (10), pp. 1439-1447. Date of Electronic Publication: 2018 Sep 10.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.

Authors: Cleghorn LAT Ray PC Odingo J et al.

Source: Journal of medicinal chemistry [J Med Chem] 2018 Aug 09; Vol. 61 (15), pp. 6592-6608. Date of Electronic Publication: 2018 Jul 26.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.

Authors: Murugesan D Ray PC Bayliss T et al.

Source: ACS infectious diseases [ACS Infect Dis] 2018 Jun 08; Vol. 4 (6), pp. 954-969. Date of Electronic Publication: 2018 Mar 26.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE