Search Results - "Fallan C"

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Discovery of AZD9750, an Orally Bioavailable Androgen Receptor Degrader for the Treatment of Prostate Cancer.

Authors: Scott JS Evans L Astles PC et al.

Source: Journal of medicinal chemistry [J Med Chem] 2026 Feb 12; Vol. 69 (3), pp. 3209-3232. Date of Electronic Publication: 2026 Jan 29.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Structural and Physicochemical Features of Oral PROTACs.

Authors: Schade M Scott JS Hayhow TG et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Aug 08; Vol. 67 (15), pp. 13106-13116. Date of Electronic Publication: 2024 Jul 30.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer.

Authors: Bagal SK Astles PC Diène C et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Jul 25; Vol. 67 (14), pp. 11732-11750. Date of Electronic Publication: 2024 Jul 11.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC.

Authors: Hayhow TG Williamson B Lawson M et al.

Source: Communications biology [Commun Biol] 2024 May 13; Vol. 7 (1), pp. 563. Date of Electronic Publication: 2024 May 13.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

Visible Light-Mediated Cyclisation Reaction for the Synthesis of Highly-Substituted Tetrahydroquinolines and Quinolines.

Authors: Sherborne GJ Kemmitt P Prentice C et al.

Source: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2023 Jan 09; Vol. 62 (2), pp. e202207829. Date of Electronic Publication: 2022 Dec 07.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8H-purin-8-one Inhibitors of DNA-PK.

Authors: Goldberg FW Ting AKT Beattie D et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Jul 07; Vol. 13 (8), pp. 1295-1301. Date of Electronic Publication: 2022 Jul 07 (Print Publication: 2022).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Skipped Fluorination Motifs: Synthesis of Building Blocks and Comparison of Lipophilicity Trends with Vicinal and Isolated Fluorination Motifs.

Authors: Troup RI Jeffries B Saudain RE et al.

Source: The Journal of organic chemistry [J Org Chem] 2021 Jan 15; Vol. 86 (2), pp. 1882-1900. Date of Electronic Publication: 2021 Jan 05.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE

A Buchwald-Hartwig Protocol to Enable Rapid Linker Exploration of Cereblon E3-Ligase PROTACs*.

Authors: Hayhow TG Borrows REA Diène CR et al.

Source: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Dec 15; Vol. 26 (70), pp. 16818-16823. Date of Electronic Publication: 2020 Nov 03.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry Subsets: MEDLINE

Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors.

Authors: Degorce SL Aagaard A Anjum R et al.

Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2020 Dec 01; Vol. 28 (23), pp. 115815. Date of Electronic Publication: 2020 Oct 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups.

Authors: Jeffries B Wang Z Troup RI et al.

Source: Beilstein journal of organic chemistry [Beilstein J Org Chem] 2020 Sep 02; Vol. 16, pp. 2141-2150. Date of Electronic Publication: 2020 Sep 02 (Print Publication: 2020).

Publication Type: Journal Article

Journal Info: Publisher: Beilstein-Institut Country of Publication: Germany NLM ID: 101250746 Publication Model: eCollection Cited Medium: Print ISSN: 1860-5397 (Print) Linking ISSN: 18605397 NLM ISO Abbreviation: Beilstein J Org Chem Subsets: PubMed not MEDLINE

The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor.

Authors: Goldberg FW Finlay MRV Ting AKT et al.

Source: Journal of medicinal chemistry [J Med Chem] 2020 Apr 09; Vol. 63 (7), pp. 3461-3471. Date of Electronic Publication: 2020 Jan 15.

Publication Type: News

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Current strategies for the design of PROTAC linkers: a critical review.

Authors: Troup RI Fallan C Baud MGJ

Source: Exploration of targeted anti-tumor therapy [Explor Target Antitumor Ther] 2020; Vol. 1 (5), pp. 273-312. Date of Electronic Publication: 2020 Oct 30.

Publication Type: Journal Article; Review

Journal Info: Publisher: Open Exploration Country of Publication: United States NLM ID: 101770662 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2692-3114 (Electronic) Linking ISSN: 26923114 NLM ISO Abbreviation: Explor Target Antitumor Ther Subsets: PubMed not MEDLINE

Proteolysis targeting chimeras (PROTACs) in 'beyond rule-of-five' chemical space: Recent progress and future challenges.

Authors: Edmondson SD Yang B Fallan C

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 Jul 01; Vol. 29 (13), pp. 1555-1564. Date of Electronic Publication: 2019 Apr 20.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

A C=O⋅⋅⋅Isothiouronium Interaction Dictates Enantiodiscrimination in Acylative Kinetic Resolutions of Tertiary Heterocyclic Alcohols.

Authors: Greenhalgh MD Smith SM Walden DM et al.

Source: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2018 Mar 12; Vol. 57 (12), pp. 3200-3206. Date of Electronic Publication: 2018 Feb 19.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: PubMed not MEDLINE

N- to C-sulfonyl photoisomerisation of dihydropyridinones: a synthetic and mechanistic study.

Authors: Yeh PP Taylor JE Stark DG et al.

Source: Organic & biomolecular chemistry [Org Biomol Chem] 2017 Oct 31; Vol. 15 (42), pp. 8914-8922.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Print Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: PubMed not MEDLINE

Non-bonding 1,5-S···O interactions govern chemo- and enantioselectivity in isothiourea-catalyzed annulations of benzazoles.

Authors: Robinson ERT Walden DM Fallan C et al.

Source: Chemical science [Chem Sci] 2016 Dec 01; Vol. 7 (12), pp. 6919-6927. Date of Electronic Publication: 2016 Jul 04.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

Enantioselective synthesis of 2,3-disubstituted trans-2,3-dihydrobenzofurans using a Brønsted base/thiourea bifunctional catalyst.

Authors: Barrios Antúnez DJ Greenhalgh MD Fallan C et al.

Source: Organic & biomolecular chemistry [Org Biomol Chem] 2016 Jul 26; Vol. 14 (30), pp. 7268-74.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Print Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE

Asymmetric Isothiourea-Catalysed Formal [3+2] Cycloadditions of Ammonium Enolates with Oxaziridines.

Authors: Smith SR Fallan C Taylor JE et al.

Source: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2015 Jul 13; Vol. 21 (29), pp. 10530-6. Date of Electronic Publication: 2015 Jun 12.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry Subsets: PubMed not MEDLINE

Exploring the scope of the isothiourea-mediated synthesis of dihydropyridinones.

Authors: Yeh PP Daniels DS Fallan C et al.

Source: Organic & biomolecular chemistry [Org Biomol Chem] 2015 Feb 21; Vol. 13 (7), pp. 2177-91.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Print Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: PubMed not MEDLINE