Search Results - "Fanning SW"

A non-enzymatic role for METTL3 as an Androgen Receptor co-regulator that promotes prostate cancer proliferation.

Authors: Kostlan RJ Phoenix JT Budreika A et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jul 09. Date of Electronic Publication: 2026 Jul 09.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Inhibition of NR2F2 restores hormone therapy response to endocrine refractory breast cancers.

Authors: Cai Y Zhao P Wu F et al.

Source: Science translational medicine [Sci Transl Med] 2025 Jun 04; Vol. 17 (801), pp. eadk7786. Date of Electronic Publication: 2025 Jun 04.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

Allosteric Induction of Estrogen Receptor Ligand Binding Domain Tetramerization by a Distinct Complete Estrogen Receptor Antagonist.

Authors: Fink EC Chawla R Hancock GR et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2026 Jan 16; Vol. 17 (2), pp. 441-449. Date of Electronic Publication: 2026 Jan 16 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Androgen receptor monomers and dimers regulate opposing biological processes in prostate cancer cells.

Authors: Safi R Wardell SE Watkinson P et al.

Source: Nature communications [Nat Commun] 2024 Sep 03; Vol. 15 (1), pp. 7675. Date of Electronic Publication: 2024 Sep 03.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Estrogen Receptor Alpha Mutations, Truncations, Heterodimers, and Therapies.

Authors: Hancock GR Gertz J Jeselsohn R et al.

Source: Endocrinology [Endocrinology] 2024 Apr 29; Vol. 165 (6).

Publication Type: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE

SOX2 utilizes FOXA1 as a heteromeric transcriptional partner to drive proliferation in therapy-resistant prostate cancer.

Authors: Phoenix JT Budreika A Schmeck DA et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jul 19. Date of Electronic Publication: 2025 Jul 19.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Benzestrol Isomer Stereochemistry Determines the Distinct Estrogenic Activities and Conformations of the Eight Isomers When Bound to Estrogen Receptor α.

Authors: Hou Y Nwachukwu JC Carlson K et al.

Source: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2025 Jul 09; Vol. 8 (8), pp. 2526-2535. Date of Electronic Publication: 2025 Jul 09 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101721411 Publication Model: eCollection Cited Medium: Internet ISSN: 2575-9108 (Electronic) Linking ISSN: 25759108 NLM ISO Abbreviation: ACS Pharmacol Transl Sci Subsets: PubMed not MEDLINE

Editorial: Hormone resistance in cancer.

Authors: Phoenix JT Budreika A Kostlan RJ et al.

Source: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Aug 24; Vol. 14, pp. 1272932. Date of Electronic Publication: 2023 Aug 24 (Print Publication: 2023).

Publication Type: Editorial

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE

Discovery of Palazestrant (OP-1250), a Potent and Orally Bioavailable Complete Estrogen Receptor Antagonist (CERAN) and Selective Estrogen Receptor Degrader (SERD).

Authors: Ng RA Barratt S Parisian A et al.

Source: ACS omega [ACS Omega] 2025 May 29; Vol. 10 (22), pp. 22685-22700. Date of Electronic Publication: 2025 May 29 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE

Imlunestrant a next-generation oral SERD overcomes ESR1 mutant resistance in estrogen receptor-positive breast cancer.

Authors: Sherman S Sandusky ZM Russo D et al.

Source: JCI insight [JCI Insight] 2025 May 06; Vol. 10 (12). Date of Electronic Publication: 2025 May 06 (Print Publication: 2025).

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: eCollection Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC).

Authors: Monsen PJ Bommi PV Grigorescu AA et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Feb 27; Vol. 68 (4), pp. 4961-4987. Date of Electronic Publication: 2025 Feb 13.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

The Homeobox Transcription Factor NKX3.1 Displays an Oncogenic Role in Castration-Resistant Prostate Cancer Cells.

Authors: Budreika A Phoenix JT Kostlan RJ et al.

Source: Cancers [Cancers (Basel)] 2025 Jan 18; Vol. 17 (2). Date of Electronic Publication: 2025 Jan 18.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE

Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells.

Authors: Young KS Hancock GR Fink EC et al.

Source: Breast cancer research : BCR [Breast Cancer Res] 2025 Jan 17; Vol. 27 (1), pp. 10. Date of Electronic Publication: 2025 Jan 17.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100927353 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-542X (Electronic) Linking ISSN: 14655411 NLM ISO Abbreviation: Breast Cancer Res Subsets: MEDLINE

Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells.

Authors: Hancock GR Young KS Hosfield DJ et al.

Source: NPJ breast cancer [NPJ Breast Cancer] 2022 Dec 14; Vol. 8 (1), pp. 130. Date of Electronic Publication: 2022 Dec 14.

Publication Type: Journal Article

Journal Info: Publisher: Breast Cancer Research Foundation Country of Publication: United States NLM ID: 101674891 Publication Model: Electronic Cited Medium: Print ISSN: 2374-4677 (Print) Linking ISSN: 23744677 NLM ISO Abbreviation: NPJ Breast Cancer Subsets: PubMed not MEDLINE

Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.

Authors: Hosfield DJ Weber S Li NS et al.

Source: ELife [Elife] 2022 May 16; Vol. 11. Date of Electronic Publication: 2022 May 16.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't

Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

Development of NR0B2 as a therapeutic target for the re-education of tumor associated myeloid cells.

Authors: Vidana Gamage HE Albright ST Smith AJ et al.

Source: Cancer letters [Cancer Lett] 2024 Aug 10; Vol. 597, pp. 217086. Date of Electronic Publication: 2024 Jun 27.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE

NR0B2 re-educates myeloid immune cells to reduce regulatory T cell expansion and progression of breast and other solid tumors.

Authors: Vidana Gamage HE Shahoei SH Wang Y et al.

Source: Cancer letters [Cancer Lett] 2024 Aug 10; Vol. 597, pp. 217042. Date of Electronic Publication: 2024 Jun 20.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE

Targeting Unique Ligand Binding Domain Structural Features Downregulates DKK1 in Y537S ESR1 Mutant Breast Cancer Cells.

Authors: Young KS Hancock GR Fink E et al.

Source: Research square [Res Sq] 2024 Jun 25. Date of Electronic Publication: 2024 Jun 25.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE

Targeting Unique Ligand Binding Domain Structural Features Downregulates DKK1 in Y537S ESR1 Mutant Breast Cancer Cells.

Authors: Young KS Hancock GR Fink E et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 02. Date of Electronic Publication: 2024 Jun 02.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.

Authors: Boudreau MW Duraki D Wang L et al.

Source: Science translational medicine [Sci Transl Med] 2021 Jul 21; Vol. 13 (603).

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE