Search Results - "Foley, Timothy L."

Phosphopantetheinyl transferase inhibition and secondary metabolism.

Authors: Foley, Timothy L. Young, Brian S. Burkart, Michael D.

Source: FEBS Journal. Dec2009, Vol. 276 Issue 23, p7134-7145. 12p. 5 Diagrams, 2 Graphs.

A simple method for determining compound affinity and chemical yield from DNA-encoded library selections.

Authors: Hall, Justin Foley, Timothy L. Chen, Qiuxia et al.

Source: Biochemical & Biophysical Research Communications. Jun2020, Vol. 527 Issue 1, p250-256. 7p.

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4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide(ML267), a Potent Inhibitor of Bacterial Phosphopantetheinyl TransferaseThat Attenuates Secondary Metabolism and Thwarts Bacterial Growth.

Authors: Foley, Timothy L. Rai, Ganesha Yasgar, Adam et al.

Source: Journal of Medicinal Chemistry. Feb2014, Vol. 57 Issue 3, p1063-1078. 16p.

A homogeneous resonance energy transfer assay for phosphopantetheinyl transferase

Authors: Foley, Timothy L. Burkart, Michael D.

Source: Analytical Biochemistry. Nov2009, Vol. 394 Issue 1, p39-47. 9p.

Site-specific protein modification: advances and applications

Authors: Foley, Timothy L Burkart, Michael D

Source: Current Opinion in Chemical Biology. Feb2007, Vol. 11 Issue 1, p12-19. 8p.

Manipulation of Carrier Proteins in Antibiotic Biosynthesis

Authors: La Clair, James J. Foley, Timothy L. Schegg, Tracy R. et al.

Source: Chemistry & Biology. Feb2004, Vol. 11 Issue 2, p195. 7p.

A method for estimating binding affinity from primary DEL selection data.

Authors: Chen, Qiuxia Hall, Justin Foley, Timothy L. et al.

Source: Biochemical & Biophysical Research Communications. Dec2020, Vol. 533 Issue 2, p249-255. 7p.

Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery.

Authors: Coussens, Nathan P. Sittampalam, G. Sitta Guha, Rajarshi et al.

Source: CTS: Clinical & Translational Science. Sep2018, Vol. 11 Issue 5, p461-470. 10p.

In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels.

Authors: Cherry, Jonathan J. DiDonato, Christine J. Androphy, Elliot J. et al.

Source: PLoS ONE. 9/25/2017, Vol. 12 Issue 9, p1-31. 31p.

Toward the assembly and characterization of an encoded library hit confirmation platform: Bead-Assisted Ligand Isolation Mass Spectrometry (BALI-MS).

Authors: Ratnayake, Anokha S. Flanagan, Mark E. Foley, Timothy L. et al.

Source: Bioorganic & Medicinal Chemistry. Jul2021, Vol. 41, pN.PAG-N.PAG. 1p.

Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.

Authors: McAllister, Laura A. Butler, Christopher R. Mente, Scot et al.

Source: Journal of Medicinal Chemistry. 4/12/2018, Vol. 61 Issue 7, p3008-3026. 19p.

Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase.

Authors: Butler, Christopher R. Beck, Elizabeth M. Harris, Anthony et al.

Source: Journal of Medicinal Chemistry. 12/14/2017, Vol. 60 Issue 23, p9860-9873. 14p.

Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).

Authors: Gopalsamy, Ariamala Narayanan, Arjun Shenping Liu et al.

Source: Journal of Medicinal Chemistry. 4/13/2017, Vol. 60 Issue 7, p3094-3108. 15p.

Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis.

Authors: Duffen JL Crouse KK Ji L et al.

Source: Nature communications [Nat Commun] 2026 Mar 09; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 09.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Enabling Open Machine Learning of Deoxyribonucleic Acid-Encoded Library Selections to Accelerate the Discovery of Small Molecule Protein Binders.

Authors: Wellnitz J Ahmad S Bagale N et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Oct 23; Vol. 68 (20), pp. 21635-21648. Date of Electronic Publication: 2025 Oct 06.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Fluorophosphonates on-Demand: A General and Simplified Approach toward Fluorophosphonate Synthesis.

Authors: Dutra JK Foley TL Huang Z et al.

Source: Chembiochem : a European journal of chemical biology [Chembiochem] 2021 May 14; Vol. 22 (10), pp. 1769-1774. Date of Electronic Publication: 2021 Mar 12.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

Structural basis of the acyl-transfer mechanism of human GPAT1.

Authors: Johnson ZL Ammirati M Wasilko DJ et al.

Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2023 Jan; Vol. 30 (1), pp. 22-30. Date of Electronic Publication: 2022 Dec 15.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

Understanding Data Noise and Uncertainty through Analysis of Replicate Samples in DNA-Encoded Library Selection.

Authors: Zhu H Foley TL Montgomery JI et al.

Source: Journal of chemical information and modeling [J Chem Inf Model] 2022 May 09; Vol. 62 (9), pp. 2239-2247. Date of Electronic Publication: 2021 Dec 04.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-960X (Electronic) Linking ISSN: 15499596 NLM ISO Abbreviation: J Chem Inf Model Subsets: MEDLINE

Selecting Approaches for Hit Identification and Increasing Options by Building the Efficient Discovery of Actionable Chemical Matter from DNA-Encoded Libraries.

Authors: Foley TL Burchett W Chen Q et al.

Source: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Feb; Vol. 26 (2), pp. 263-280. Date of Electronic Publication: 2021 Jan 08.

Publication Type: Journal Article

Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE