Search Results - "Freestone GC"

Targeting the non-coding RNA-PANoptosis axis: a novel frontier in disease diagnosis and therapy.

Authors: Wang S Feng C Chen X et al.

Source: Apoptosis : an international journal on programmed cell death [Apoptosis] 2026 Aug 07; Vol. 31 (8). Date of Electronic Publication: 2026 Aug 07.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 9712129 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-675X (Electronic) Linking ISSN: 13608185 NLM ISO Abbreviation: Apoptosis Subsets: MEDLINE

The choice of negative control antisense oligonucleotides dramatically impacts downstream analysis depending on the cellular background.

Authors: Ducoli, Luca Agrawal, Saumya Hon, Chung-Chau et al.

Source: BMC Genomic Data. 9/14/2021, Vol. 22 Issue 1, p1-10. 10p.

Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties.

Authors: Hudson AR Santora VJ Petroski RE et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Jul 15; Vol. 30 (14), pp. 127214. Date of Electronic Publication: 2020 Apr 25.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Targeting Lipoprotein(a): Can RNA Therapeutics Provide the Next Step in the Prevention of Cardiovascular Disease?

Authors: Thau, Henriette Neuber, Sebastian Emmert, Maximilian Y. et al.

Source: Cardiology & Therapy. Mar2024, Vol. 13 Issue 1, p39-67. 29p.

Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles.

Authors: Østergaard ME Carrer M Anderson BA et al.

Source: Nucleic acids research [Nucleic Acids Res] 2025 Apr 10; Vol. 53 (7).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Whole mitochondrial genome sequencing in individuals with Leber hereditary optic neuropathy negative for the common pathogenic mitochondrial DNA variants.

Authors: Srilekha S Ambika S Hemavathy N et al.

Source: Frontiers in neurology [Front Neurol] 2025 Sep 01; Vol. 16, pp. 1584748. Date of Electronic Publication: 2025 Sep 01 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101546899 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2295 (Print) Linking ISSN: 16642295 NLM ISO Abbreviation: Front Neurol Subsets: PubMed not MEDLINE

The efficacy of oligonucleotide-based gene therapeutics in gene silencing.

Authors: Patra C Hussein Z Ace VD et al.

Source: Theranostics [Theranostics] 2026 Jan 01; Vol. 16 (2), pp. 599-616. Date of Electronic Publication: 2026 Jan 01 (Print Publication: 2026).

Publication Type: Journal Article; Review

Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.

Authors: Anderson BA Freestone GC Low A et al.

Source: Nucleic acids research [Nucleic Acids Res] 2021 Sep 20; Vol. 49 (16), pp. 9026-9041.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs.

Authors: Vasquez G Freestone GC Wan WB et al.

Source: Nucleic acids research [Nucleic Acids Res] 2021 Feb 26; Vol. 49 (4), pp. 1828-1839.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

A therapeutic approach for the hepatitis C virus: in silico design of an antisense oligonucleotide-based candidate capsid inhibitor.

Authors: Hasturk B Eren F

Source: Virus genes [Virus Genes] 2024 Oct; Vol. 60 (5), pp. 446-454. Date of Electronic Publication: 2024 Jul 31.

Publication Type: Journal Article

Journal Info: Publisher: Kluwer Academic Country of Publication: United States NLM ID: 8803967 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1572-994X (Electronic) Linking ISSN: 09208569 NLM ISO Abbreviation: Virus Genes Subsets: MEDLINE

Toxicologic Pathology Forum: Opinion on Interpretive Challenges for Procedure-Related Effects Associated With Direct Central Nervous System Delivery of Oligonucleotides to Rodents, Dogs, and Nonhuman Primates.

Authors: Berman-Booty LD Klein SK Mazur C et al.

Source: Toxicologic pathology [Toxicol Pathol] 2023 Aug; Vol. 51 (6), pp. 375-389. Date of Electronic Publication: 2024 Jan 05.

Publication Type: Journal Article

Journal Info: Publisher: Sage Publications Country of Publication: United States NLM ID: 7905907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-1601 (Electronic) Linking ISSN: 01926233 NLM ISO Abbreviation: Toxicol Pathol Subsets: MEDLINE

Chemerin knockout reveals sex difference in the role of chemerin in blood pressure and vascular remodeling.

Authors: Wabel E Garver H Krieger-Burke T et al.

Source: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2026 Jul 01; Vol. 331 (1), pp. H166-H181. Date of Electronic Publication: 2026 Jun 01.

Publication Type: Journal Article

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1539 (Electronic) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE

Phosphorothioate antisense oligonucleotide induced innate immune activation is attenuated by tryptophan oxidation products.

Authors: Pytte J Saldana L Zhang W et al.

Source: Nucleic acids research [Nucleic Acids Res] 2026 Apr 13; Vol. 54 (7).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Discovery of long-acting APOC3 siRNA for treating patients with hypertriglyceridemia.

Authors: Prakash TP Mullick AE Riney S et al.

Source: Nucleic acids research [Nucleic Acids Res] 2025 Oct 28; Vol. 53 (20).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Single alkyl phosphonate modification of the siRNA backbone in the seed region enhances specificity and therapeutic profile.

Authors: Nikan M Li Q Tanowitz M et al.

Source: Nucleic acids research [Nucleic Acids Res] 2025 Jul 19; Vol. 53 (14).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Evolution of antisense oligonucleotides: navigating nucleic acid chemistry and delivery challenges.

Authors: Ruchi R Raman GM Kumar V et al.

Source: Expert opinion on drug discovery [Expert Opin Drug Discov] 2025 Jan; Vol. 20 (1), pp. 63-80. Date of Electronic Publication: 2024 Dec 17.

Publication Type: Journal Article; Review

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101295755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1746-045X (Electronic) Linking ISSN: 17460441 NLM ISO Abbreviation: Expert Opin Drug Discov Subsets: MEDLINE

KCTD17-mediated Ras stabilization promotes hepatocellular carcinoma progression.

Authors: Jung YH Lee YJ Dao T et al.

Source: Clinical and molecular hepatology [Clin Mol Hepatol] 2024 Oct; Vol. 30 (4), pp. 895-913. Date of Electronic Publication: 2024 Aug 05.

Publication Type: Journal Article

Journal Info: Publisher: Korean Association for the Study of the Liver Country of Publication: Korea (South) NLM ID: 101586730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2287-285X (Electronic) Linking ISSN: 22872728 NLM ISO Abbreviation: Clin Mol Hepatol Subsets: MEDLINE

New insights into the therapeutic approaches for the treatment of tauopathies.

Authors: Singh H Das A Khan MM et al.

Source: Neural regeneration research [Neural Regen Res] 2024 May; Vol. 19 (5), pp. 1020-1026.

Publication Type: Journal Article

Journal Info: Publisher: Wolters Kluwer Health, Medknow Country of Publication: India NLM ID: 101316351 Publication Model: Print Cited Medium: Print ISSN: 1673-5374 (Print) Linking ISSN: 16735374 NLM ISO Abbreviation: Neural Regen Res Subsets: PubMed not MEDLINE

Updates in Small Interfering RNA for the Treatment of Dyslipidemias.

Authors: Carugo S Sirtori CR Gelpi G et al.

Source: Current atherosclerosis reports [Curr Atheroscler Rep] 2023 Nov; Vol. 25 (11), pp. 805-817. Date of Electronic Publication: 2023 Oct 04.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 100897685 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-6242 (Electronic) Linking ISSN: 15233804 NLM ISO Abbreviation: Curr Atheroscler Rep Subsets: MEDLINE

Nonviral delivery systems for antisense oligonucleotide therapeutics.

Authors: Huang S Hao XY Li YJ et al.

Source: Biomaterials research [Biomater Res] 2022 Sep 30; Vol. 26 (1), pp. 49. Date of Electronic Publication: 2022 Sep 30.

Publication Type: Journal Article; Review

Journal Info: Publisher: AAAS Science Partner Journals Country of Publication: United States NLM ID: 101650636 Publication Model: Electronic Cited Medium: Print ISSN: 1226-4601 (Print) Linking ISSN: 12264601 NLM ISO Abbreviation: Biomater Res Subsets: PubMed not MEDLINE