Search Results - "Freestone PS"

Antiseizure Medications that Did Not Reach the Epilepsy Market: An Assessment of Factors Contributing to Their Failed Clinical Development Over the Last Three Decades.

Authors: Bialer M Perucca E

Source: Drugs [Drugs] 2026 May; Vol. 86 (5), pp. 599-625. Date of Electronic Publication: 2026 Mar 01.

Publication Type: Journal Article; Review

Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 7600076 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1950 (Electronic) Linking ISSN: 00126667 NLM ISO Abbreviation: Drugs Subsets: MEDLINE

The Double-Edged Effect of Connexins and Pannexins of Glial Cells in Central and Peripheral Nervous System After Nerve Injury.

Authors: Cen YY Gao XL Feng YH et al.

Source: Molecular neurobiology [Mol Neurobiol] 2025 Nov; Vol. 62 (11), pp. 14474-14518. Date of Electronic Publication: 2025 May 01.

Publication Type: Journal Article; Review

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

Evaluation of ocular tolerability and bioavailability of tonabersat transfersomes ex vivo.

Authors: Bhujbal S Rupenthal ID Agarwal P

Source: Drug delivery and translational research [Drug Deliv Transl Res] 2026 Apr; Vol. 16 (4), pp. 1222-1232. Date of Electronic Publication: 2025 May 13.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE; In Process

Distinct dopaminergic spike-timing-dependent plasticity rules are suited to different functional roles.

Authors: Sosis B Rubin JE

Source: Biological cybernetics [Biol Cybern] 2026 May 11; Vol. 120 (3-4). Date of Electronic Publication: 2026 May 11.

Publication Type: Journal Article

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7502533 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0770 (Electronic) Linking ISSN: 03401200 NLM ISO Abbreviation: Biol Cybern Subsets: MEDLINE

The Effects of Carvacrol on Transient Receptor Potential (TRP) Channels in an Animal Model of Parkinson's Disease.

Authors: Akan, Tülay Aydın, Yasemin Korkmaz, Orhan Tansel et al.

Source: Neurotoxicity Research. Dec2023, Vol. 41 Issue 6, p660-669. 10p.

Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease.

Authors: Matschke, Lina A. Komadowski, Marlene A. Stöhr, Annette et al.

Source: Scientific Reports. 2/24/2022, Vol. 12 Issue 1, p1-14. 14p.

Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease.

Authors: Pike, Adrianne F. Longhena, Francesca Faustini, Gaia et al.

Source: Journal of Neuroinflammation. 2/16/2022, Vol. 19 Issue 1, p1-16. 16p.

Formulation and characterization of transfersomes for ocular delivery of tonabersat.

Authors: Bhujbal, Santosh Rupenthal, Ilva D. Agarwal, Priyanka

Source: Pharmaceutical Development & Technology. Jun2025, Vol. 30 Issue 5, p558-571. 14p.

Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling.

Authors: Yu, Hailong Cao, Xiang Li, Wei et al.

Source: Journal of Neuroinflammation. 10/28/2020, Vol. 17 Issue 1, p1-19. 19p.

Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra.

Authors: Burkert, Nicole Roy, Shoumik Häusler, Max et al.

Source: Communications Biology. 11/10/2023, Vol. 6 Issue 1, p1-26. 26p.

Inhibition of ventral tegmental area projections to the paraventricular thalamus attenuates conditioned cues-induced heroin seeking behavior in rats.

Authors: Zhou Y Li W Cai D et al.

Source: Metabolic brain disease [Metab Brain Dis] 2025 Oct 27; Vol. 40 (8), pp. 298. Date of Electronic Publication: 2025 Oct 27.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 8610370 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7365 (Electronic) Linking ISSN: 08857490 NLM ISO Abbreviation: Metab Brain Dis Subsets: MEDLINE

Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma: A preclinical F98 glioblastoma rat model study.

Authors: De Meulenaere, Valerie Bonte, Ellen Verhoeven, Jeroen et al.

Source: PLoS ONE. 10/21/2019, Vol. 14 Issue 10, p1-17. 17p.

The role of high‐conductance calcium‐activated potassium channel in headache and migraine pathophysiology.

Authors: Al‐Karagholi, Mohammad Al‐Mahdi Hakbilen, Cemile Ceren Ashina, Messoud

Source: Basic & Clinical Pharmacology & Toxicology. Nov2022, Vol. 131 Issue 5, p347-354. 8p.

Reversal of dopamine-mediated firing inhibition through activation of the dopamine transporter in substantia nigra pars compacta neurons.

Authors: Aversa, Daniela Martini, Alessandro Guatteo, Ezia et al.

Source: British Journal of Pharmacology. Sep2018, Vol. 175 Issue 17, p3534-3547. 14p. 6 Graphs.

Identification of N-arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1 receptors.

Authors: Redmond, William J. Cawston, Erin E. Grimsey, Natasha L. et al.

Source: British Journal of Pharmacology. Jan2016, Vol. 173 Issue 1, p115-127. 13p. 1 Chart, 7 Graphs.

Promising cannabinoid-based therapies for Parkinson's disease: motor symptoms to neuroprotection.

Authors: Vasant More, Sandeep Dong-Kug Choi

Source: Molecular Neurodegeneration. 2015, Vol. 10 Issue 1, p1-26. 26p. 2 Diagrams, 1 Chart.

The Pathophysiologic Roles of TRPM7 Channel.

Authors: Hyun Soo Park Chansik Hong Byung Joo Kim et al.

Source: Korean Journal of Physiology & Pharmacology. Feb2014, Vol. 18 Issue 1, p15-23. 9p.

MPP⁺-dependent inhibition of Ih reduces spontaneous activity and enhances EPSP summation in nigral dopamine neurons.

Authors: Masi, A Narducci, R Landucci, E et al.

Source: British Journal of Pharmacology. May2013, Vol. 169 Issue 1, p130-142. 13p.

Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson's disease models.

Authors: Xiong, Nian Long, Xi Xiong, Jing et al.

Source: Critical Reviews in Toxicology. Aug2012, Vol. 42 Issue 7, p613-632. 20p. 2 Diagrams, 3 Charts.

In Vitro Maturation of Dopaminergic Neurons Derived from Mouse Embryonic Stem Cells: Implications for Transplantation.

Authors: Watmuff, Bradley Pouton, Colin W. Haynes, John M.

Source: PLoS ONE. Feb2012, Vol. 7 Issue 2, p1-11. 11p.