Search Results - "Freundlich JS"

ag85A loss promotes free mycolate accumulation and sensitizes plasma membrane domain to disruption.

Authors: Kado T Shivangi Bosworth PH et al.

Source: Journal of bacteriology [J Bacteriol] 2026 Jul 14, pp. e0024026. Date of Electronic Publication: 2026 Jul 14.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 2985120R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5530 (Electronic) Linking ISSN: 00219193 NLM ISO Abbreviation: J Bacteriol Subsets: MEDLINE

Rifamycin Structural Modifications Attenuate PXR Binding and CYP3A4 Induction.

Authors: George A Lan T Huber AD et al.

Source: Journal of medicinal chemistry [J Med Chem] 2026 Jul 09; Vol. 69 (13), pp. 15858-15871. Date of Electronic Publication: 2026 Jun 23.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning.

Authors: Lepori I Liu Z Evbarunegbe N et al.

Source: Nature microbiology [Nat Microbiol] 2026 Jun 30. Date of Electronic Publication: 2026 Jun 30.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE

Loss of essential outer membrane functions causes drug hypersensitization in Acinetobacter baumannii overexpressing multidrug efflux pumps.

Authors: Hamami E Huo W Neal K et al.

Source: MBio [mBio] 2026 Jun 24, pp. e0090226. Date of Electronic Publication: 2026 Jun 24.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

Dynamic ¹¹C-Para-Aminobenzoic Acid Positron Emission Tomography/Computed Tomography for Visualizing Pulmonary Mycobacteroides abscessus Infections.

Authors: Masias-Leon Y Ruiz-Gonzalez CE Nino-Meza OJ et al.

Source: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2025 Jul; Vol. 211 (7), pp. 1253-1263.

Publication Type: Journal Article; Observational Study; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Thoracic Society Country of Publication: England NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE

A multiplex method for rapidly identifying viral protease inhibitors.

Authors: Hong SJ Resnick SJ Iketani S et al.

Source: Molecular systems biology [Mol Syst Biol] 2025 Feb; Vol. 21 (2), pp. 158-172. Date of Electronic Publication: 2025 Jan 06.

Publication Type: Journal Article

Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101235389 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4292 (Electronic) Linking ISSN: 17444292 NLM ISO Abbreviation: Mol Syst Biol Subsets: MEDLINE

The Quantification of Drug Accumulation within Gram-Negative Bacteria.

Authors: George A Shivangi Bozan A et al.

Source: ACS infectious diseases [ACS Infect Dis] 2026 Jan 09; Vol. 12 (1), pp. 410-424. Date of Electronic Publication: 2025 Dec 24.

Publication Type: Journal Article

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

Loss of Ag85A disrupts plasma membrane domains and promotes free mycolic acid accumulation in mycobacteria.

Authors: Kado T Shivangi Jordan J et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Aug 05. Date of Electronic Publication: 2025 Aug 05.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

The Mycomembrane Differentially and Heterogeneously Restricts Antibiotic Permeation.

Authors: Lepori I Jackson K Liu Z et al.

Source: ACS infectious diseases [ACS Infect Dis] 2025 Jul 11; Vol. 11 (7), pp. 1893-1906. Date of Electronic Publication: 2025 Jun 05.

Publication Type: Journal Article

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

Improved Radiosynthesis of [¹⁸F]-Labeled Oxazolidinone Antibiotics for Future Clinical Translation.

Authors: Sarhan M Shelke AM Mane K et al.

Source: ACS infectious diseases [ACS Infect Dis] 2025 Jul 11; Vol. 11 (7), pp. 2009-2017. Date of Electronic Publication: 2025 Jun 12.

Publication Type: Journal Article

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

Proton gradient controls the lateral rearrangement of inner membrane domains in response to membrane fluidizer stress in Mycobacterium smegmatis.

Authors: Prithviraj M Shivangi Freundlich JS et al.

Source: The Journal of biological chemistry [J Biol Chem] 2025 Jul; Vol. 301 (7), pp. 110361. Date of Electronic Publication: 2025 Jun 11.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

The KasA inhibitor JSF-3285 improves the sterilizing activity of bedaquiline-pretomanid-containing regimens in a mouse model of tuberculosis.

Authors: Soni H Tyagi S Mane K et al.

Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2025 Jun 04; Vol. 69 (6), pp. e0013025. Date of Electronic Publication: 2025 Apr 23.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

The Quantification of Drug Accumulation within Gram-Negative Bacteria.

Authors: George A Shivangi Bozan A et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 May 29. Date of Electronic Publication: 2025 May 29.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Evolution of Small Molecule Inhibitors of Mycobacterium tuberculosis Menaquinone Biosynthesis.

Authors: Sharma P Jiang Q Li SG et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Mar 13; Vol. 68 (5), pp. 5774-5803. Date of Electronic Publication: 2025 Mar 04.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Identification of chemical features that influence mycomembrane permeation and antitubercular activity.

Authors: Lepori I Liu Z Evbarunegbe N et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Feb 27. Date of Electronic Publication: 2025 Feb 27.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Identification of Antituberculars with Favorable Potency and Pharmacokinetics through Structure-Based and Ligand-Based Modeling.

Authors: Warapande V Meng F Bozan A et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Feb 04. Date of Electronic Publication: 2025 Feb 04.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Identification of Cysteine Metabolism Regulator (CymR)-Derived Pentapeptides as Nanomolar Inhibitors of Staphylococcus aureus O-Acetyl-l-serine Sulfhydrylase (CysK).

Authors: Pederick JL Vandborg BC George A et al.

Source: ACS infectious diseases [ACS Infect Dis] 2025 Jan 10; Vol. 11 (1), pp. 238-248. Date of Electronic Publication: 2024 Dec 20.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

Mycobacterium tuberculosis KasA as a drug target: Structure-based inhibitor design.

Authors: Rudraraju RS Daher SS Gallardo-Macias R et al.

Source: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Sep 15; Vol. 12, pp. 1008213. Date of Electronic Publication: 2022 Sep 15 (Print Publication: 2022).

Publication Type: Journal Article; Review; Research Support, N.I.H., Extramural

Journal Info: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE

Identification of cysteine metabolism regulator (CymR)-derived pentapeptides as nanomolar inhibitors of Staphylococcus aureus O-acetyl-ʟ-serine sulfhydrylase (CysK).

Authors: Pederick JL Vandborg BC George A et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 20. Date of Electronic Publication: 2024 Sep 20.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs.

Authors: Chen X Arun B Nino-Meza OJ et al.

Source: Nature communications [Nat Commun] 2024 Aug 14; Vol. 15 (1), pp. 6657. Date of Electronic Publication: 2024 Aug 14.

Publication Type: Journal Article; Observational Study; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE