Search Results - "Gaskell PC"

Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review.

Authors: Liu, Shiying Bush, William S. Akinyemi, Rufus Olusola et al.

Source: PLoS Genetics. 9/4/2025, Vol. 21 Issue 9, p1-23. 23p.

Impact of APOE ε4 and ε2 on plasma neurofilament light chain and cognition in autosomal dominant Alzheimer's disease.

Authors: Langella, Stephanie Bonta, Kyra Chen, Yinghua et al.

Source: Alzheimer's Research & Therapy. 10/1/2024, Vol. 16 Issue 1, p1-9. 9p.

The APOE ε4 allele affects the survival of patients with Parkinson's disease independent of dementia.

Authors: Wang, Zheng Li, Lu Xu, Qian et al.

Source: Journal of Translational Medicine. 10/14/2025, Vol. 23 Issue 1, p1-17. 17p.

A reproducible approach for the use of aptamer libraries for the identification of Aptamarkers for brain amyloid deposition based on plasma analysis.

Authors: Meehan, Cathal Lecocq, Soizic Penner, Gregory

Source: PLoS ONE. 8/27/2024, Vol. 19 Issue 8, p1-15. 15p.

β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity.

Authors: Holmes, Brandon B. Weigel, Thaddeus K. Chung, Jesseca M. et al.

Source: Molecular Neurodegeneration. 8/29/2025, Vol. 20 Issue 1, p1-27. 27p.

Multi-omics analysis for identifying cell-type-specific and bulk-level druggable targets in Alzheimer's disease.

Authors: Liu, Shiwei Cho, Minyoung Huang, Yen-Ning et al.

Source: Journal of Translational Medicine. 7/18/2025, Vol. 23 Issue 1, p1-18. 18p.

Interpretable multivariate survival models: Improving predictions for conversion from mild cognitive impairment to Alzheimer's disease via data fusion and machine learning.

Authors: Rosales-Gurmendi, Diana Sofia Fumagal-González, Gerardo Alejandro Orozco, Jorge et al.

Source: PLoS ONE. 4/30/2026, Vol. 21 Issue 4, p1-21. 21p.

A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry.

Authors: Rajabli, Farid Beecham, Gary W. Hendrie, Hugh C. et al.

Source: PLoS Genetics. 7/5/2022, Vol. 18 Issue 7, p1-15. 15p.

Fueling the brain - the role of apolipoprotein E in brain energy metabolism and its implications for Alzheimer's disease.

Authors: Budny V Ruminot I Wybitul M et al.

Source: Translational psychiatry [Transl Psychiatry] 2025 Aug 25; Vol. 15 (1), pp. 316. Date of Electronic Publication: 2025 Aug 25.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE

Diabetes mellitus and risk of incident dementia in APOE ɛ4 carriers: an updated meta-analysis.

Authors: Rashtchian, Ava Etemadi, Mohammad Hossein Asadi, Elham et al.

Source: BMC Neuroscience. 6/25/2024, Vol. 25 Issue 1, p1-10. 10p.

py_ped_sim: a flexible forward pedigree and genetic simulator for complex family pedigree analysis.

Authors: Guardado, Miguel Perez, Cynthia Campana, Sthen et al.

Source: BMC Bioinformatics. 5/7/2025, Vol. 26 Issue 1, p1-18. 18p.

Sequence and trajectory of early Alzheimer's disease-related tau inclusions in the hippocampal formation of cases without amyloid-β deposits.

Authors: Braak H Mayer B Feldengut S et al.

Source: Acta neuropathologica [Acta Neuropathol] 2025 May 23; Vol. 149 (1), pp. 50. Date of Electronic Publication: 2025 May 23.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE

Pros and Cons of Human Brain Organoids to Study Alzheimer's Disease.

Authors: Sainz, Andrea Pérez-Cerdá, Fernando Pérez-Samartín, Alberto et al.

Source: Aging & Disease. Dec2025, Vol. 16 Issue 6, p3483-3504. 22p.

APOE4 reprograms microglial lipid metabolism in Alzheimer's disease: Mechanisms and therapeutic implications.

Authors: Jiajie Chen Shuoyan Zhao Yingying Zhou et al.

Source: BioScience Trends. Dec2025, Vol. 19 Issue 6, p641-658. 18p.

Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD.

Authors: Wang, Shaowei Li, Boyang Li, Jie et al.

Source: Molecular Neurodegeneration. 2/4/2025, Vol. 20 Issue 1, p1-26. 26p.

Lower neurovascular coupling response despite higher cerebral blood flow at rest in apolipoprotein ɛ4 positive adults.

Authors: Pearson, Andrew G. Miller, Kathleen B. Corkery, Adam T. et al.

Source: PLoS ONE. 12/3/2024, Vol. 19 Issue 12, p1-17. 17p.

A novel truncated variant in SPAST results in spastin accumulation and defects in microtubule dynamics.

Authors: Wang, Jie Wu, Yihan Dong, Hong et al.

Source: BMC Medical Genomics. 12/8/2023, Vol. 16 Issue 1, p1-9. 9p.

Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience.

Authors: Walker, Keenan A. An, Yang Moghekar, Abhay et al.

Source: Molecular Neurodegeneration. 10/31/2024, Vol. 19 Issue 1, p1-18. 18p.

Amyloid-β Peptide-targeting Immunotherapy in Alzheimer Disease: A Systematic Review of Clinical Studies.

Authors: Mosleh, Haideh Ghayyem, Hani Sharifpour, Sanaz et al.

Source: Caspian Journal of Neurological Sciences. Autumn2024, Vol. 10 Issue 4, p247-265. 19p.

Associations of combined accelerated biological aging and genetic susceptibility with incident dementia: a prospective study in the UK Biobank.

Authors: Ye, Zirong Lang, Haoxiang Xie, Zishan et al.

Source: BMC Medicine. 9/30/2024, Vol. 22 Issue 1, p1-14. 14p.