Search Results - "Harding HP"

Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis.

Authors: Cunha DA Igoillo-Esteve M Gurzov EN et al.

Source: Diabetes. Nov2012, Vol. 61 Issue 11, p2763-2775. 13p.

Metabolite import by SLC33A1 is required for ATF6 activation during endoplasmic reticulum stress.

Authors: George G Harding HP Kay R et al.

Source: Life science alliance [Life Sci Alliance] 2026 Apr 17; Vol. 9 (6). Date of Electronic Publication: 2026 Apr 17 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE

A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response.

Authors: Shilliday F Gancedo-Rodrigo M George G et al.

Source: Nature communications [Nat Commun] 2026 May 06; Vol. 17 (1). Date of Electronic Publication: 2026 May 06.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells.

Authors: Neidhardt L Cloots E Friemel N et al.

Source: The EMBO journal [EMBO J] 2024 Mar; Vol. 43 (5), pp. 719-753. Date of Electronic Publication: 2023 Dec 18.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

Infancy-onset diabetes caused by de-regulated AMPylation of the human endoplasmic reticulum chaperone BiP.

Authors: Perera LA Hattersley AT Harding HP et al.

Source: EMBO molecular medicine [EMBO Mol Med] 2023 Mar 08; Vol. 15 (3), pp. e16491. Date of Electronic Publication: 2023 Jan 27.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE

Protocol for iterative enrichment of integrated sgRNAs via derivative CRISPR-Cas9 libraries from genomic DNA of sorted fixed cells.

Authors: Ordóñez A Ron D Harding HP

Source: STAR protocols [STAR Protoc] 2024 Dec 20; Vol. 5 (4), pp. 103493. Date of Electronic Publication: 2024 Dec 10.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101769501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-1667 (Electronic) Linking ISSN: 26661667 NLM ISO Abbreviation: STAR Protoc Subsets: MEDLINE

A genome-wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α.

Authors: Tung J Huang L George G et al.

Source: ELife [Elife] 2024 Jul 29; Vol. 13. Date of Electronic Publication: 2024 Jul 29.

Publication Type: Journal Article

Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response.

Authors: Yan Y Shetty M Harding HP et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Apr 02; Vol. 121 (14), pp. e2320013121. Date of Electronic Publication: 2024 Mar 28.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.

Authors: Zyryanova AF Weis F Faille A et al.

Source: Science (New York, N.Y.) [Science] 2018 Mar 30; Vol. 359 (6383), pp. 1533-1536.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Higher-order phosphatase-substrate contacts terminate the integrated stress response.

Authors: Yan Y Harding HP Ron D

Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Oct; Vol. 28 (10), pp. 835-846. Date of Electronic Publication: 2021 Oct 08.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.

Authors: Sekine Y Zyryanova A Crespillo-Casado A et al.

Source: PloS one [PLoS One] 2016 Nov 03; Vol. 11 (11), pp. e0166278. Date of Electronic Publication: 2016 Nov 03 (Print Publication: 2016).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Skeletal muscle-specific eukaryotic translation initiation factor 2α phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism.

Authors: Miyake M Nomura A Ogura A et al.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2016 Feb; Vol. 30 (2), pp. 798-812. Date of Electronic Publication: 2015 Oct 20.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly.

Authors: Abdulkarim B Nicolino M Igoillo-Esteve M et al.

Source: Diabetes [Diabetes] 2015 Nov; Vol. 64 (11), pp. 3951-62. Date of Electronic Publication: 2015 Jul 09.

Publication Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE

Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers.

Authors: Ordóñez A Harding HP Marciniak SJ et al.

Source: Cell reports [Cell Rep] 2021 May 18; Vol. 35 (7), pp. 109144.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

ISRIB Blunts the Integrated Stress Response by Allosterically Antagonising the Inhibitory Effect of Phosphorylated eIF2 on eIF2B.

Authors: Zyryanova AF Kashiwagi K Rato C et al.

Source: Molecular cell [Mol Cell] 2021 Jan 07; Vol. 81 (1), pp. 88-103.e6. Date of Electronic Publication: 2020 Nov 20.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.

Authors: Sekine Y Zyryanova A Crespillo-Casado A et al.

Source: Science (New York, N.Y.) [Science] 2015 May 29; Vol. 348 (6238), pp. 1027-30. Date of Electronic Publication: 2015 Apr 09.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum.

Authors: Avezov E Konno T Zyryanova A et al.

Source: BMC biology [BMC Biol] 2015 Jan 10; Vol. 13, pp. 2. Date of Electronic Publication: 2015 Jan 10.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190720 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7007 (Electronic) Linking ISSN: 17417007 NLM ISO Abbreviation: BMC Biol Subsets: MEDLINE

Impaired eukaryotic translation initiation factor 2B activity specifically in oligodendrocytes reproduces the pathology of vanishing white matter disease in mice.

Authors: Lin Y Pang X Huang G et al.

Source: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2014 Sep 03; Vol. 34 (36), pp. 12182-91.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

Targeting the unfolded protein response in disease.

Authors: Hetz C Chevet E Harding HP

Source: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2013 Sep; Vol. 12 (9), pp. 703-19.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124171 Publication Model: Print Cited Medium: Internet ISSN: 1474-1784 (Electronic) Linking ISSN: 14741776 NLM ISO Abbreviation: Nat Rev Drug Discov Subsets: MEDLINE

Nine-year risk of depression diagnosis increases with increasing self-reported concussions in retired professional football players.

Authors: Kerr ZY Marshall SW Harding HP Jr et al.

Source: The American journal of sports medicine [Am J Sports Med] 2012 Oct; Vol. 40 (10), pp. 2206-12. Date of Electronic Publication: 2012 Aug 24.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Sage Publications Country of Publication: United States NLM ID: 7609541 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-3365 (Electronic) Linking ISSN: 03635465 NLM ISO Abbreviation: Am J Sports Med Subsets: MEDLINE