Search Results - "Harding RJ"

High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds.

Authors: Yang D Wang X Liu J et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 23; Vol. 123 (25), pp. e2515940123. Date of Electronic Publication: 2026 Jun 05.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

High-affinity, structure-validated and selective macrocyclic peptide tools for chemical biology studies of Huntingtin.

Authors: Fanti R Wolf E Ikenoue T et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Mar 24; Vol. 123 (12), pp. e2520462123. Date of Electronic Publication: 2026 Mar 16.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Development of a Dual Chemical Probe for the USP16 and HDAC6 Zinc-Finger Ubiquitin-Binding Domain.

Authors: Silva M Mann M Mirabi B et al.

Source: Journal of medicinal chemistry [J Med Chem] 2026 Mar 12; Vol. 69 (5), pp. 5703-5711. Date of Electronic Publication: 2026 Feb 20.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion.

Authors: Collotta G Gatti M Ungureanu IM et al.

Source: Nature communications [Nat Commun] 2026 Mar 06; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 06.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Novel monoclonal antibodies against the C-terminal HEAT domain of huntingtin.

Authors: Park YN Fanti R Sadeghi S et al.

Source: Journal of Huntington's disease [J Huntingtons Dis] 2026 Mar 05, pp. 18796397261426634. Date of Electronic Publication: 2026 Mar 05.

Publication Type: Journal Article

Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101589965 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-6400 (Electronic) Linking ISSN: 18796397 NLM ISO Abbreviation: J Huntingtons Dis Subsets: MEDLINE

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.

Authors: Herasymenko O Silva M Correy GJ et al.

Source: Journal of chemical information and modeling [J Chem Inf Model] 2026 Feb 09; Vol. 66 (3), pp. 1566-1581. Date of Electronic Publication: 2026 Jan 21.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-960X (Electronic) Linking ISSN: 15499596 NLM ISO Abbreviation: J Chem Inf Model Subsets: MEDLINE

PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites.

Authors: Yadav M AlQazzaz MA Ciamponi FE et al.

Source: Nucleic acids research [Nucleic Acids Res] 2025 Apr 22; Vol. 53 (8).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification.

Authors: Harding RJ Xie Y Caron NS et al.

Source: Biomarker research [Biomark Res] 2025 Apr 21; Vol. 13 (1), pp. 63. Date of Electronic Publication: 2025 Apr 21.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101607860 Publication Model: Electronic Cited Medium: Print ISSN: 2050-7771 (Print) Linking ISSN: 20507771 NLM ISO Abbreviation: Biomark Res Subsets: PubMed not MEDLINE

Enabling Open Machine Learning of Deoxyribonucleic Acid-Encoded Library Selections to Accelerate the Discovery of Small Molecule Protein Binders.

Authors: Wellnitz J Ahmad S Bagale N et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Oct 23; Vol. 68 (20), pp. 21635-21648. Date of Electronic Publication: 2025 Oct 06.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

High-Affinity, Structure-Validated and Selective Macrocyclic Peptide Tools for Chemical Biology Studies of Huntingtin.

Authors: Wolf E Fanti R Ikenoue T et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Aug 06. Date of Electronic Publication: 2025 Aug 06.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.

Authors: Herasymenko O Silva M Abu-Saleh AAA et al.

Source: Journal of chemical information and modeling [J Chem Inf Model] 2025 Jul 14; Vol. 65 (13), pp. 6884-6898. Date of Electronic Publication: 2025 Jun 20.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-960X (Electronic) Linking ISSN: 15499596 NLM ISO Abbreviation: J Chem Inf Model Subsets: MEDLINE

Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities.

Authors: Gusev F Gutkin E Gentile F et al.

Source: Journal of chemical information and modeling [J Chem Inf Model] 2025 Jun 09; Vol. 65 (11), pp. 5706-5717. Date of Electronic Publication: 2025 May 25.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-960X (Electronic) Linking ISSN: 15499596 NLM ISO Abbreviation: J Chem Inf Model Subsets: MEDLINE

The Canadian Open Neuroscience Platform-An open science framework for the neuroscience community.

Authors: Harding RJ Bermudez P Bernier A et al.

Corporate Authors: Harding RJ Bermudez P Bernier A et al.

Source: PLoS computational biology [PLoS Comput Biol] 2023 Jul 27; Vol. 19 (7), pp. e1011230. Date of Electronic Publication: 2023 Jul 27 (Print Publication: 2023).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7358 (Electronic) Linking ISSN: 1553734X NLM ISO Abbreviation: PLoS Comput Biol Subsets: MEDLINE

High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds.

Authors: Yang D Wang X Liu J et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Mar 25. Date of Electronic Publication: 2025 Mar 25.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain.

Authors: Geurs S Staessens E Bredael K et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Mar 05; Vol. 285, pp. 117208. Date of Electronic Publication: 2024 Dec 27.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Detection of antibodies against the huntingtin protein in human plasma.

Authors: Denis HL Alpaugh M Alvarez CP et al.

Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2023 Jan 18; Vol. 80 (2), pp. 45. Date of Electronic Publication: 2023 Jan 18.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE

Identification of Inhibitors of Chikungunya virus nsP2 ATPase.

Authors: Navarro H Scott JE Smith GR et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jan 14. Date of Electronic Publication: 2025 Jan 14.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1.

Authors: Mettu A Glavatskikh M Wang X et al.

Source: Chemical science [Chem Sci] 2025 Jan 09; Vol. 16 (8), pp. 3430-3439. Date of Electronic Publication: 2025 Jan 09 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: eCollection Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

A guide to selecting high-performing antibodies for Huntingtin (UniProt ID: P42858) for use in western blot, immunoprecipitation, and immunofluorescence.

Authors: Fanti R Ayoubi R Alende C et al.

Corporate Authors: Fanti R Ayoubi R Alende C et al.

Source: F1000Research [F1000Res] 2025 Jan 02; Vol. 13, pp. 922. Date of Electronic Publication: 2025 Jan 02 (Print Publication: 2024).

Publication Type: Journal Article

Journal Info: Publisher: F1000 Research Ltd Country of Publication: England NLM ID: 101594320 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-1402 (Electronic) Linking ISSN: 20461402 NLM ISO Abbreviation: F1000Res Subsets: MEDLINE

CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson's Disease Associated Protein.

Authors: Li F Ackloo S Arrowsmith CH et al.

Source: Journal of chemical information and modeling [J Chem Inf Model] 2024 Nov 25; Vol. 64 (22), pp. 8521-8536. Date of Electronic Publication: 2024 Nov 05.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-960X (Electronic) Linking ISSN: 15499596 NLM ISO Abbreviation: J Chem Inf Model Subsets: MEDLINE