Search Results - "Harding RJ"

High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds.

Authors: Yang D Wang X Liu J et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jun 23; Vol. 123 (25), pp. e2515940123. Date of Electronic Publication: 2026 Jun 05.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

High-affinity, structure-validated and selective macrocyclic peptide tools for chemical biology studies of Huntingtin.

Authors: Fanti R Wolf E Ikenoue T et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Mar 24; Vol. 123 (12), pp. e2520462123. Date of Electronic Publication: 2026 Mar 16.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion.

Authors: Collotta G Gatti M Ungureanu IM et al.

Source: Nature communications [Nat Commun] 2026 Mar 06; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 06.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

The Canadian Open Neuroscience Platform-An open science framework for the neuroscience community.

Authors: Harding RJ Bermudez P Bernier A et al.

Corporate Authors: Harding RJ Bermudez P Bernier A et al.

Source: PLoS computational biology [PLoS Comput Biol] 2023 Jul 27; Vol. 19 (7), pp. e1011230. Date of Electronic Publication: 2023 Jul 27 (Print Publication: 2023).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7358 (Electronic) Linking ISSN: 1553734X NLM ISO Abbreviation: PLoS Comput Biol Subsets: MEDLINE

Insights into neurodevelopmental features of Huntington's disease from stem cell-derived models including organoids.

Authors: Sierra, Mariana Powers, Rachael Grotewold, Nikolas et al.

Source: Journal of Huntington's Disease. May2026, Vol. 15 Issue 2, p214-225. 12p.

High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds.

Authors: Yang D Wang X Liu J et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Mar 25. Date of Electronic Publication: 2025 Mar 25.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Synthesis and functional screening of novel inhibitors targeting the HDAC6 zinc finger ubiquitin-binding domain.

Authors: Geurs S Staessens E Bredael K et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Mar 05; Vol. 285, pp. 117208. Date of Electronic Publication: 2024 Dec 27.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

A Review of Evapotranspiration Estimation Models: Advances and Future Development.

Authors: Xue, Yayong Zhang, Zhenshan Li, Xuliang et al.

Source: Water Resources Management. Jun2025, Vol. 39 Issue 8, p3641-3657. 17p.

Assessing ecosystem service trade-offs and synergies in the rapidly urbanizing coastal region of Mangaluru Agglomeration, India.

Authors: Nayak, Deeksha Shukla, Anoop Kumar

Source: PLoS ONE. 3/23/2026, Vol. 21 Issue 3, p1-16. 16p.

Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1.

Authors: Mettu A Glavatskikh M Wang X et al.

Source: Chemical science [Chem Sci] 2025 Jan 09; Vol. 16 (8), pp. 3430-3439. Date of Electronic Publication: 2025 Jan 09 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: eCollection Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

Revisiting huntingtin activity and localization signals in the context of protein structure.

Authors: Truant R Harding RJ Neuman K et al.

Source: Journal of Huntington's disease [J Huntingtons Dis] 2024 Nov; Vol. 13 (4), pp. 419-430. Date of Electronic Publication: 2024 Nov 10.

Publication Type: Journal Article; Review

Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101589965 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-6400 (Electronic) Linking ISSN: 18796397 NLM ISO Abbreviation: J Huntingtons Dis Subsets: MEDLINE

Autoinhibition of ubiquitin-specific protease 8: Insights into domain interactions and mechanisms of regulation.

Authors: Caba C Black M Liu Y et al.

Source: The Journal of biological chemistry [J Biol Chem] 2024 Oct; Vol. 300 (10), pp. 107727. Date of Electronic Publication: 2024 Aug 28.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Pathobiology of the autophagy-lysosomal pathway in the Huntington's disease brain.

Authors: Berg, Martin J. Veeranna Rosa, Corrinne M. et al.

Source: Acta Neuropathologica Communications. 11/7/2025, Vol. 13 Issue 1, p1-26. 26p.

Tipping the PARylation scale: Dysregulation of PAR signaling in Huntington and neurodegenerative diseases.

Authors: Peng, Christina Maiuri, Tamara Truant, Ray

Source: Journal of Huntington's Disease. Nov2025, Vol. 14 Issue 4, p293-303. 11p.

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Luteolin as potential treatment for Huntington's disease: Insights from a transgenic mouse model.

Authors: Mohammed, Abuelnor Ramadan, Azza Elnour, Asim Ahmed et al.

Source: CNS Neuroscience & Therapeutics. Sep2024, Vol. 30 Issue 9, p1-12. 12p.

Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle.

Authors: Mann MK Wolf E Silva M et al.

Source: ACS omega [ACS Omega] 2023 Dec 15; Vol. 9 (1), pp. 917-924. Date of Electronic Publication: 2023 Dec 15 (Print Publication: 2024).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE

Disease–disease interactions: molecular links of neurodegenerative diseases with cancer, viral infections, and type 2 diabetes.

Authors: Lin, Yuxi Yoo, Je Min Li, Yan et al.

Source: Translational Neurodegeneration. 10/17/2025, Vol. 14 Issue 1, p1-26. 26p.

Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.

Authors: Gall-Duncan T Luo J Jurkovic CM et al.

Source: Cell [Cell] 2023 Oct 26; Vol. 186 (22), pp. 4898-4919.e25. Date of Electronic Publication: 2023 Oct 11.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40.

Authors: Alteen MG Deme JC Alvarez CP et al.

Source: Structure (London, England : 1993) [Structure] 2023 Sep 07; Vol. 31 (9), pp. 1121-1131.e6. Date of Electronic Publication: 2023 Jun 29.

Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE