Search Results - "Hardingham, Giles E."

CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV.

Authors: Chawla, Sangeeta Hardingham, Giles E. Quinn, David R.

Source: Science; September 4 1998, Vol. 281 Issue 5382, p1505-1509, 5p

Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration.

Authors: Patani, Rickie Hardingham, Giles E. Liddelow, Shane A.

Source: Nature Reviews Neurology. Jul2023, Vol. 19 Issue 7, p395-409. 15p.

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Good, bad, and neglectful: Astrocyte changes in neurodegenerative disease.

Authors: Jiwaji, Zoeb Hardingham, Giles E.

Source: Free Radical Biology & Medicine. Mar2022, Vol. 182, p93-99. 7p.

In Cortical Neurons HDAC3 Activity Suppresses RD4- Dependent SMRT Export.

Authors: Soriano, Francesc X. Hardingham, Giles E.

Source: PLoS ONE. 2011, Vol. 6 Issue 6, p1-8. 8p.

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders.

Authors: Hardingham, Giles E. Bading, Hilmar

Source: Nature Reviews Neuroscience. Oct2010, Vol. 11 Issue 10, p682-696. 15p. 1 Black and White Photograph, 6 Diagrams.

Subjects: Methyl aspartate, Neurodegeneration, Neural receptors, Neural stimulation, Cell death, Etiology of diseases, Animal experimentation, Cell receptors, Cellular signal transduction, Comparative studies, Gene expression, Research methodology, Medical cooperation, Nervous system, Research, Oxidative stress, Evaluation research, Neuroprotective agents

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses.

Authors: Papadia, Sofia Soriano, Francesc X. Léveillé, Frédéric et al.

Source: Nature Neuroscience. Apr2008, Vol. 11 Issue 4, p476-487. 12p. 9 Graphs.

Subjects: Antioxidants, Nervous system, Longevity, Methyl aspartate, Heredity

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways.

Authors: Hardingham, Giles E. Fukunaga, Yuko Bading, Hilmar

Source: Nature Neuroscience. May2002, Vol. 5 Issue 5, p405. 10p.

Subjects: Methyl aspartate, Cyclic adenylic acid, Gene expression

Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity.

Authors: Hardingham, Giles E. Arnold, Fiona J. L. Bading, Hilmar

Source: Nature Neuroscience. Mar2001, Vol. 4 Issue 3, p261. 7p.

Subjects: Calcium, Nervous system, Synapses, Gene expression

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GRIN2A-related disorders: genotype and functional consequence predict phenotype.

Authors: Strehlow, Vincent Heyne, Henrike O Vlaskamp, Danique R M et al.

Source: Brain: A Journal of Neurology; Jan2019, Vol. 142 Issue 1, p80-92, 13p

The Regulation of Astrocytic Glutamate Transporters in Health and Neurodegenerative Diseases.

Authors: Todd, Alison C. Hardingham, Giles E.

Source: International Journal of Molecular Sciences. Dec2020, Vol. 21 Issue 24, p9607. 1p.

Lineage divergence of activity-driven transcription and evolution of cognitive ability.

Authors: Hardingham, Giles E. Pruunsild, Priit Greenberg, Michael E. et al.

Source: Nature Reviews Neuroscience. Jan2018, Vol. 19 Issue 1, p9-15. 7p. 2 Diagrams, 1 Chart.

Subjects: RNA physiology, Animals, Cell differentiation, Cognition, Genes, Immunity, Mice, Neural transmission, Research funding

Transcriptional regulators of redox balance and other homeostatic processes with the potential to alter neurodegenerative disease trajectory.

Authors: Burnside, Scott W. Hardingham, Giles E.

Source: Biochemical Society Transactions. 12/15/2017, Vol. 45 Issue 6, p1295-1303. 9p.

NMDA Receptor C-Terminal Domain Signalling in Development, Maturity, and Disease.

Authors: Haddow, Kirsty Kind, Peter C. Hardingham, Giles E.

Source: International Journal of Molecular Sciences. Oct2022, Vol. 23 Issue 19, p11392. 20p.

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Adaptive regulation of the brain’s antioxidant defences by neurons and astrocytes.

Authors: Baxter, Paul S. Hardingham, Giles E.

Source: Free Radical Biology & Medicine. Nov2016, Vol. 100, p147-152. 6p.

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis.

Authors: Hardingham, Giles E. Do, Kim Q.

Source: Nature Reviews Neuroscience. Feb2016, Vol. 17 Issue 2, p125-134. 10p. 2 Color Photographs, 3 Diagrams.

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