Search Results - "Harikumar KB"

Uttroside B, a US FDA-designated 'Orphan Drug', mitigates the development of hepatocellular carcinoma and its pulmonary metastasis via EGFR/ERK-mediated inhibition of SREBP-1 and STAT-3.

Authors: Keerthana CK Rayginia TP Kalimuthu K et al.

Source: Cell death discovery [Cell Death Discov] 2026 Apr 16; Vol. 12 (1). Date of Electronic Publication: 2026 Apr 16.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE

Navigating the complexities of epigenetic dysregulation in breast cancer and its implication in therapeutic interventions: a comprehensive overview.

Authors: Ravindran S Vini R Rajavelu A et al.

Source: Molecular and cellular biochemistry [Mol Cell Biochem] 2026 Jan; Vol. 481 (1), pp. 171-186. Date of Electronic Publication: 2025 Oct 23.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE

Orphan drug uttroside B impedes MASH progression and HCC development in experimental models.

Authors: Rayginia TP Keerthana CK Aiswarya SU et al.

Source: JHEP reports : innovation in hepatology [JHEP Rep] 2025 Oct 10; Vol. 8 (2), pp. 101626. Date of Electronic Publication: 2025 Oct 10 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101761237 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-5559 (Electronic) Linking ISSN: 25895559 NLM ISO Abbreviation: JHEP Rep Subsets: In Process

Therapeutic options in hepatocellular carcinoma: a comprehensive review.

Authors: Suresh D Srinivas AN Prashant A et al.

Source: Clinical and experimental medicine [Clin Exp Med] 2023 Oct; Vol. 23 (6), pp. 1901-1916. Date of Electronic Publication: 2023 Feb 13.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100973405 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1591-9528 (Electronic) Linking ISSN: 15918890 NLM ISO Abbreviation: Clin Exp Med Subsets: MEDLINE

Editorial: Targeting Pancreatic Cancer: Strategies and Hopes.

Authors: Manu KA Harikumar KB Ishimoto T

Source: Frontiers in oncology [Front Oncol] 2022 Mar 31; Vol. 12, pp. 873682. Date of Electronic Publication: 2022 Mar 31 (Print Publication: 2022).

Publication Type: Editorial

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE

Targeting acid ceramidase enhances antitumor immune response in colorectal cancer.

Authors: Vijayan Y James S Viswanathan A et al.

Source: Journal of advanced research [J Adv Res] 2024 Nov; Vol. 65, pp. 73-87. Date of Electronic Publication: 2023 Dec 21.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE

Beyond cyclopamine: Targeting Hedgehog signaling for cancer intervention.

Authors: Thazhackavayal Baby B Kulkarni AM Gayam PKR et al.

Source: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2024 Apr; Vol. 754, pp. 109952. Date of Electronic Publication: 2024 Mar 01.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372430 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0384 (Electronic) Linking ISSN: 00039861 NLM ISO Abbreviation: Arch Biochem Biophys Subsets: MEDLINE

Deletion or inhibition of SphK1 mitigates fulminant hepatic failure by suppressing TNFα-dependent inflammation and apoptosis.

Authors: Avni D Harikumar KB Sanyal AJ et al.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2021 Mar; Vol. 35 (3), pp. e21415.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

Modulatory Role of Phytochemicals/Natural Products in Cancer Immunotherapy.

Authors: Vijayan Y Sandhu JS Harikumar KB

Source: Current medicinal chemistry [Curr Med Chem] 2024; Vol. 31 (32), pp. 5165-5177.

Publication Type: Journal Article; Review

Journal Info: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9440157 Publication Model: Print Cited Medium: Internet ISSN: 1875-533X (Electronic) Linking ISSN: 09298673 NLM ISO Abbreviation: Curr Med Chem Subsets: MEDLINE

A Novel Combinatorial Regimen Using Sorafenib and Uttroside B, A US FDA-designated 'Orphan Drug', for the Treatment of Hepatocellular Carcinoma.

Authors: Keerthana CK Aiswarya SU Rayginia TP et al.

Source: Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2024; Vol. 24 (19), pp. 1431-1441.

Publication Type: Journal Article

Journal Info: Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 101265649 Publication Model: Print Cited Medium: Internet ISSN: 1875-5992 (Electronic) Linking ISSN: 18715206 NLM ISO Abbreviation: Anticancer Agents Med Chem Subsets: MEDLINE

Sphingosine 1-phosphate signaling during infection and immunity.

Authors: Mohammed S Bindu A Viswanathan A et al.

Source: Progress in lipid research [Prog Lipid Res] 2023 Nov; Vol. 92, pp. 101251. Date of Electronic Publication: 2023 Aug 24.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Pergamon Country of Publication: England NLM ID: 7900832 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2194 (Electronic) Linking ISSN: 01637827 NLM ISO Abbreviation: Prog Lipid Res Subsets: MEDLINE

Regulatory role of SphK1 in TLR7/9-dependent type I interferon response and autoimmunity.

Authors: Mohammed S Vineetha NS James S et al.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Mar; Vol. 34 (3), pp. 4329-4347. Date of Electronic Publication: 2020 Jan 23.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

Computational drug repurposing of Akt-1 allosteric inhibitors for non-small cell lung cancer.

Authors: Baby K Maity S Mehta CH et al.

Source: Scientific reports [Sci Rep] 2023 May 16; Vol. 13 (1), pp. 7947. Date of Electronic Publication: 2023 May 16.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Examination of the role of sphingosine kinase 2 in a murine model of systemic lupus erythematosus.

Authors: Mohammed S Vineetha NS James S et al.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2019 Jun; Vol. 33 (6), pp. 7061-7071. Date of Electronic Publication: 2019 Mar 06.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

TAMing pancreatic cancer: combat with a double edged sword.

Authors: Lankadasari MB Mukhopadhyay P Mohammed S et al.

Source: Molecular cancer [Mol Cancer] 2019 Mar 30; Vol. 18 (1), pp. 48. Date of Electronic Publication: 2019 Mar 30.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer

Cross-talk between AMP-activated protein kinase and the sonic hedgehog pathway in the high-fat diet triggered colorectal cancer.

Authors: Beena TB Jesil MA Harikumar KB

Source: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2023 Feb; Vol. 735, pp. 109500. Date of Electronic Publication: 2023 Jan 04.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372430 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0384 (Electronic) Linking ISSN: 00039861 NLM ISO Abbreviation: Arch Biochem Biophys Subsets: MEDLINE

Corrigendum: Sphingosine 1-Phosphate: A Novel Target for Lung Disorders.

Authors: Mohammed S Harikumar KB

Source: Frontiers in immunology [Front Immunol] 2018 Jul 17; Vol. 9, pp. 1628. Date of Electronic Publication: 2018 Jul 17 (Print Publication: 2018).

Publication Type: Journal Article; Published Erratum

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Print ISSN: 1664-3224 (Print) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: PubMed not MEDLINE

Enhanced expression of histone chaperone APLF associate with breast cancer.

Authors: Majumder A Syed KM Mukherjee A et al.

Source: Molecular cancer [Mol Cancer] 2018 Mar 26; Vol. 17 (1), pp. 76. Date of Electronic Publication: 2018 Mar 26.

Publication Type: Letter; Research Support, Non-U.S. Gov't

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer

The Origin and Functions of Exosomes in Cancer.

Authors: Rajagopal C Harikumar KB

Source: Frontiers in oncology [Front Oncol] 2018 Mar 20; Vol. 8, pp. 66. Date of Electronic Publication: 2018 Mar 20 (Print Publication: 2018).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE

Augmented Efficacy of Uttroside B over Sorafenib in a Murine Model of Human Hepatocellular Carcinoma.

Authors: Swetha M Keerthana CK Rayginia TP et al.

Source: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 May 22; Vol. 15 (5). Date of Electronic Publication: 2022 May 22.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE