Search Results - "Holland-Letz, Tim"

Simple, robust and near optimal designs for the estimation of log-logistic dose response functions.

Authors: Holland-Letz, Tim Kopp-Schneider, Annette

Source: Archives of Toxicology. Jun2026, Vol. 100 Issue 6, p2451-2465. 15p.

Early-detection and prevention effects of screening sigmoidoscopy: evidence from randomized trials revisited.

Authors: Brenner, Hermann Holland-Letz, Tim Kopp-Schneider, Annette et al.

Source: JNCI: Journal of the National Cancer Institute. Mar2026, Vol. 118 Issue 3, p422-428. 7p.

The design heatmap: A simple visualization of D‐optimality design problems.

Authors: Holland‐Letz, Tim Kopp‐Schneider, Annette

Source: Biometrical Journal. Dec2020, Vol. 62 Issue 8, p2013-2031. 19p.

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Modeling dose–response functions for combination treatments with log-logistic or Weibull functions.

Authors: Holland-Letz, Tim Leibner, Alexander Kopp-Schneider, Annette

Source: Archives of Toxicology. Jan2020, Vol. 94 Issue 1, p197-204. 8p. 3 Graphs.

Response prediction of ¹⁷⁷Lu-PSMA-617 RLT using PSA, Chromogranin A, and LDH.

Authors: Rathke, Hendrik Holland-Letz, Tim Mier, Walter et al.

Source: Journal of Nuclear Medicine. Dec2019, Vol. 60 Issue 12, Preceding p1-27. 28p.

Parametric modeling and optimal experimental designs for estimating isobolograms for drug interactions in toxicology.

Authors: Holland-Letz, Tim Gunkel, Nikolas Amtmann, Eberhard et al.

Source: Journal of Biopharmaceutical Statistics. 2018, Vol. 28 Issue 4, p763-777. 15p. 1 Chart, 3 Graphs.

Highly efficient destruction of squamous carcinoma cells of the head and neck by photochemical internalization of Ranpirnase.

Authors: Liebers, Nora Holland-Letz, Tim Welschof, Mona et al.

Source: Journal of Experimental Therapeutics & Oncology. 2017, Vol. 12 Issue 2, p113-120. 8p.

On the combination of c- and D-optimal designs: General approaches and applications in dose-response studies.

Authors: Holland‐Letz, Tim¹, t.holland-letz@dkfz.de

Source: Biometrics; Mar2017, Vol. 73 Issue 1, p206-213, 8p

Optimal experimental designs for dose-response studies with continuous endpoints.

Authors: Holland-Letz, Tim Kopp-Schneider, Annette

Source: Archives of Toxicology. Nov2015, Vol. 89 Issue 11, p2059-2068. 10p. 1 Diagram, 5 Charts, 1 Graph.

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.

Authors: Walter, Dagmar Lier, Amelie Geiselhart, Anja et al.

Source: Nature. 4/23/2015, Vol. 520 Issue 7548, p549-552. 4p. 1 Diagram, 10 Graphs.

Subjects: DNA damage, Hematopoietic stem cells, Blood cells, Fanconi's anemia, Homeostasis, Physiological stress, DNA repair, Laboratory mice, Mammals

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo.

Authors: Busch, Katrin Klapproth, Kay Barile, Melania et al.

Source: Nature. 2/25/2015, Vol. 518 Issue 7540, p542-546. 5p. 1 Chart, 14 Graphs.

Subjects: Hematopoietic stem cells, Stem cell transplantation research, Human chromosomes, Immune system, Hematopoiesis

Drawing statistical conclusions from experiments with multiple quantitative measurements per subject.

Authors: Holland-Letz, Tim Kopp-Schneider, Annette

Source: Radiotherapy & Oncology. Nov2020, Vol. 152, p30-33. 4p.

Subjects: Standard deviations, Statistical models, Confidence intervals, Measurement, Experiments

Efficient Algorithms for Optimal Designs with Correlated Observations in Pharmacokinetics and Dose-Finding Studies.

Authors: Holland-Letz, Tim Dette, Holger Renard, Didier

Source: Biometrics; Mar2012, Vol. 68 Issue 1, p138-146, 8p

A geometric characterization of optimal designs for regression models with correlated observations.

Authors: Holland-Letz, Tim Dette, Holger Pepelyshev, Andrey

Source: Journal of the Royal Statistical Society: Series B (Statistical Methodology); Mar2011, Vol. 73 Issue 2, p239-252, 14p

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Association of nucleated red blood cells in blood and arterial oxygen partial tension.

Authors: Kuert, Sandra Holland-Letz, Tim Friese, Jochen et al.

Source: Clinical Chemistry & Laboratory Medicine. Feb2011, Vol. 49 Issue 2, p257-263. 7p. 5 Charts, 2 Graphs.

Reproducibility and reliability of the ankle-brachial index as assessed by vascular experts, family physicians and nurses.

Authors: Holland-Letz, Tim Endres, Heinz G. Biedermann, Stefanie et al.

Source: Vascular Medicine. 2007, Vol. 12 Issue 2, p105-112. 8p.

Poor prognosis indicated by nucleated red blood cells in peripheral blood is not associated with organ failure of the liver or kidney.

Authors: Stachon, Axel Holland-Letz, Tim Kempf, Reiner et al.

Source: Clinical Chemistry & Laboratory Medicine. Aug2006, Vol. 44 Issue 8, p955-961. 7p. 4 Charts, 4 Graphs.

High in-hospital mortality of intensive care patients with nucleated red blood cells in blood.

Authors: Stachon, Axel Holland-Letz, Tim Krieg, Michael

Source: Clinical Chemistry & Laboratory Medicine. Aug2004, Vol. 42 Issue 8, p933-938. 6p.