Search Results - "Hoth LR"

Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies.

Authors: Conrad KS Cheng TW Ysselstein D et al.

Source: Nature communications [Nat Commun] 2017 Dec 04; Vol. 8 (1), pp. 1908. Date of Electronic Publication: 2017 Dec 04.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators.

Authors: Rajamohan F Reyes AR Frisbie RK et al.

Source: The Biochemical journal [Biochem J] 2016 Mar 01; Vol. 473 (5), pp. 581-92. Date of Electronic Publication: 2015 Dec 03.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease.

Authors: Rajamohan F Reyes AR Tu M et al.

Source: Journal of lipid research [J Lipid Res] 2020 Aug; Vol. 61 (8), pp. 1192-1202. Date of Electronic Publication: 2020 Jun 01.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0376606 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-7262 (Electronic) Linking ISSN: 00222275 NLM ISO Abbreviation: J Lipid Res Subsets: MEDLINE

A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification.

Authors: Nolte WM Fortin JP Stevens BD et al.

Source: Nature chemical biology [Nat Chem Biol] 2014 Aug; Vol. 10 (8), pp. 629-31. Date of Electronic Publication: 2014 Jul 06.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

Crystal structures of interleukin 17A and its complex with IL-17 receptor A.

Authors: Liu S Song X Chrunyk BA et al.

Source: Nature communications [Nat Commun] 2013; Vol. 4, pp. 1888.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia.

Authors: Cunningham D Danley DE Geoghegan KF et al.

Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2007 May; Vol. 14 (5), pp. 413-9. Date of Electronic Publication: 2007 Apr 15.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1545-9993 (Print) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules.

Authors: Qiu X Mistry A Ammirati MJ et al.

Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2007 Feb; Vol. 14 (2), pp. 106-13. Date of Electronic Publication: 2007 Jan 21.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1545-9993 (Print) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

Introduction of a Crystalline, Shelf-Stable Reagent for the Synthesis of Sulfur(VI) Fluorides.

Authors: Zhou H Mukherjee P Liu R et al.

Source: Organic letters [Org Lett] 2018 Feb 02; Vol. 20 (3), pp. 812-815. Date of Electronic Publication: 2018 Jan 12.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: PubMed not MEDLINE

Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue.

Authors: Fadeyi OO Hoth LR Choi C et al.

Source: ACS chemical biology [ACS Chem Biol] 2017 Aug 18; Vol. 12 (8), pp. 2015-2020. Date of Electronic Publication: 2017 Jul 20.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system.

Authors: Caspers NL Han S Rajamohan F et al.

Source: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2016 Nov 01; Vol. 72 (Pt 11), pp. 840-845. Date of Electronic Publication: 2016 Oct 27.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons Inc Country of Publication: United States NLM ID: 101620319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2053-230X (Electronic) Linking ISSN: 2053230X NLM ISO Abbreviation: Acta Crystallogr F Struct Biol Commun Subsets: MEDLINE

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists.

Authors: Liu S Dakin LA Xing L et al.

Source: Scientific reports [Sci Rep] 2016 Aug 16; Vol. 6, pp. 30859. Date of Electronic Publication: 2016 Aug 16.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Expression and functional characterization of human lysosomal acid lipase gene (LIPA) mutation responsible for cholesteryl ester storage disease (CESD) phenotype.

Authors: Rajamohan F Reyes AR Ruangsiriluk W et al.

Source: Protein expression and purification [Protein Expr Purif] 2015 Jun; Vol. 110, pp. 22-9. Date of Electronic Publication: 2015 Jan 22.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9101496 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0279 (Electronic) Linking ISSN: 10465928 NLM ISO Abbreviation: Protein Expr Purif Subsets: MEDLINE

Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.

Authors: Calabrese MF Rajamohan F Harris MS et al.

Source: Structure (London, England : 1993) [Structure] 2014 Aug 05; Vol. 22 (8), pp. 1161-1172. Date of Electronic Publication: 2014 Jul 24.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry.

Authors: Landgraf RR Goswami D Rajamohan F et al.

Source: Structure (London, England : 1993) [Structure] 2013 Nov 05; Vol. 21 (11), pp. 1942-53. Date of Electronic Publication: 2013 Sep 26.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

Unexpected mucin-type O-glycosylation and host-specific N-glycosylation of human recombinant interleukin-17A expressed in a human kidney cell line.

Authors: Geoghegan KF Song X Hoth LR et al.

Source: Protein expression and purification [Protein Expr Purif] 2013 Jan; Vol. 87 (1), pp. 27-34. Date of Electronic Publication: 2012 Oct 13.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9101496 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0279 (Electronic) Linking ISSN: 10465928 NLM ISO Abbreviation: Protein Expr Purif Subsets: MEDLINE

Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase.

Authors: Rajamohan F Harris MS Frisbie RK et al.

Source: Protein expression and purification [Protein Expr Purif] 2010 Oct; Vol. 73 (2), pp. 189-97. Date of Electronic Publication: 2010 May 06.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9101496 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0279 (Electronic) Linking ISSN: 10465928 NLM ISO Abbreviation: Protein Expr Purif Subsets: MEDLINE

Binding to the low-density lipoprotein receptor accelerates futile catalytic cycling in PCSK9 and raises the equilibrium level of intramolecular acylenzyme.

Authors: Geoghegan KF Hoth LR Varghese AH et al.

Source: Biochemistry [Biochemistry] 2009 Apr 07; Vol. 48 (13), pp. 2941-9.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

Biophysical and biochemical approach to locating an inhibitor binding site on cholesteryl ester transfer protein.

Authors: Cunningham D Lin W Hoth LR et al.

Source: Bioconjugate chemistry [Bioconjug Chem] 2008 Aug; Vol. 19 (8), pp. 1604-13. Date of Electronic Publication: 2008 Jul 23.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE

The 2.0 A crystal structure of the ERalpha ligand-binding domain complexed with lasofoxifene.

Authors: Vajdos FF Hoth LR Geoghegan KF et al.

Source: Protein science : a publication of the Protein Society [Protein Sci] 2007 May; Vol. 16 (5), pp. 897-905.

Publication Type: Journal Article

Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Print ISSN: 0961-8368 (Print) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

Expression and protein chemistry yielding crystallization of the catalytic domain of ADAM17 complexed with a hydroxamate inhibitor.

Authors: Hoth LR Tan DH Wang IK et al.

Source: Protein expression and purification [Protein Expr Purif] 2007 Apr; Vol. 52 (2), pp. 313-9. Date of Electronic Publication: 2006 Nov 07.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9101496 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1046-5928 (Print) Linking ISSN: 10465928 NLM ISO Abbreviation: Protein Expr Purif Subsets: MEDLINE