Search Results - "Hummersone, Marc"

N3-Substituted Temozolomide Analogs Overcome Methylguanine-DNA Methyltransferase and Mismatch Repair Precipitating Apoptotic and Autophagic Cancer Cell Death.

Authors: Zhang, Jihong Hummersone, Marc Matthews, Charles S. et al.

Source: Oncology. Dec2014, Vol. 88 Issue 1, p28-48. 21p. 2 Diagrams, 2 Charts, 8 Graphs.

Synthetic studies on the bryostatin B-ring

Authors: Hummersone, Marc Geoffery

URL: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.812685

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

Authors: Pike, Kurt G. Malagu, Karine Hummersone, Marc G. et al.

Source: Bioorganic & Medicinal Chemistry Letters. Mar2013, Vol. 23 Issue 5, p1212-1216. 5p.

Certain Imidazotetrazines Escape O6-Methylguanine-DNA Methyltransferase and Mismatch Repair.

Authors: Zhang, Jihong Stevens, Malcolm F.G. Hummersone, Marc et al.

Source: Oncology. 2011, Vol. 80 Issue 3/4, p195-207. 13p. 1 Color Photograph, 1 Diagram, 2 Charts, 3 Graphs.

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.

Authors: Rizzo, Angela Iachettini, Sara Zizza, Pasquale et al.

Source: Journal of Experimental & Clinical Cancer Research (17569966). 2014, Vol. 33 Issue 1, p1-15. 15p.

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts.

Authors: Sara Iachettini Stevens, Malcolm F. G. Frigerio, Mark et al.

Source: Journal of Experimental & Clinical Cancer Research (17569966). 2013, Vol. 32 Issue 1, p1-12. 12p.

1-Substituted(Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-onesEndowed with Dual DNA-PK/PI3-K Inhibitory Activity.

Authors: Cano, Céline Saravanan, Kappusamy Bailey, Chris et al.

Source: Journal of Medicinal Chemistry. Vol. 56 Issue 16, p6386-6401. 16p.

DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype.

Authors: Cano, Céline Barbeau, Olivier R. Bailey, Christine et al.

Source: Journal of Medicinal Chemistry. 12/23/2010, Vol. 53 Issue 24, p8498-8507. 10p.

The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase

Authors: Malagu, Karine Duggan, Heather Menear, Keith et al.

Source: Bioorganic & Medicinal Chemistry Letters. Oct2009, Vol. 19 Issue 20, p5950-5953. 4p.

Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position.

Authors: Cousin D Hummersone MG Bradshaw TD et al.

Source: MedChemComm [Medchemcomm] 2018 Jan 19; Vol. 9 (3), pp. 545-553. Date of Electronic Publication: 2018 Jan 19 (Print Publication: 2018).

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101531525 Publication Model: eCollection Cited Medium: Print ISSN: 2040-2503 (Print) Linking ISSN: 20402503 NLM ISO Abbreviation: Medchemcomm Subsets: PubMed not MEDLINE

Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities.

Authors: Rizzo A Iachettini S Zizza P et al.

Source: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2015 Feb 05; Vol. 34, pp. 9. Date of Electronic Publication: 2015 Feb 05.

Publication Type: Published Erratum

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 8308647 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-9966 (Electronic) Linking ISSN: 03929078 NLM ISO Abbreviation: J Exp Clin Cancer Res Subsets: PubMed not MEDLINE

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.

Authors: Chresta CM Davies BR Hickson I et al.

Source: Cancer research [Cancer Res] 2010 Jan 01; Vol. 70 (1), pp. 288-98. Date of Electronic Publication: 2009 Dec 22.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion.

Authors: Golding SE Rosenberg E Valerie N et al.

Source: Molecular cancer therapeutics [Mol Cancer Ther] 2009 Oct; Vol. 8 (10), pp. 2894-902. Date of Electronic Publication: 2009 Oct 06.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.

Authors: Hollick JJ Rigoreau LJ Cano-Soumillac C et al.

Source: Journal of medicinal chemistry [J Med Chem] 2007 Apr 19; Vol. 50 (8), pp. 1958-72. Date of Electronic Publication: 2007 Mar 20.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Enantioselective formal total synthesis of the antitumor macrolide bryostatin 7.

Authors: Manaviazar S Frigerio M Bhatia GS et al.

Source: Organic letters [Org Lett] 2006 Sep 28; Vol. 8 (20), pp. 4477-80.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print Cited Medium: Print ISSN: 1523-7060 (Print) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

Synthesis of a simplified bryostatin C-ring analogue that binds to the CRD2 of human PKC-alpha and construction of a novel BC-analogue by an unusual Julia olefination process.

Authors: Hale KJ Frigerio M Manaviazar S et al.

Source: Organic letters [Org Lett] 2003 Feb 20; Vol. 5 (4), pp. 499-502.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print Cited Medium: Print ISSN: 1523-7060 (Print) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

The chemistry and biology of the bryostatin antitumour macrolides.

Authors: Hale KJ Hummersone MG Manaviazar S et al.

Source: Natural product reports [Nat Prod Rep] 2002 Aug; Vol. 19 (4), pp. 413-53.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 8502408 Publication Model: Print Cited Medium: Print ISSN: 0265-0568 (Print) Linking ISSN: 02650568 NLM ISO Abbreviation: Nat Prod Rep Subsets: MEDLINE