Search Results - "INTERLEUKIN-2"

Targeting tumor-specific T cells with LAG3-directed interleukin-2 prevents T-cell exhaustion and reinvigorates antitumor immunity.

Authors: Yu X Liao H Lv J et al.

Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jun 02; Vol. 11 (1). Date of Electronic Publication: 2026 Jun 02.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE

IL-33 and IL-3 synergistically induce CD25 expression on human basophils without functional IL-2 signaling: a potential marker of severe COVID-19.

Authors: Retnakumar SV Singh SC Chauvin C et al.

Source: Frontiers in immunology [Front Immunol] 2025 Dec 11; Vol. 16, pp. 1718240. Date of Electronic Publication: 2025 Dec 11 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

The Lasting Impact of IL-2: Approaching 50 Years of Advancing Immune Tolerance, Cancer Immunotherapies, and Autoimmune Diseases.

Authors: Paul P Choong C Heinemann J et al.

Source: Immunological investigations [Immunol Invest] 2025 Jul; Vol. 54 (5), pp. 589-603. Date of Electronic Publication: 2025 Mar 17.

Publication Type: Journal Article; Review

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8504629 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-4311 (Electronic) Linking ISSN: 08820139 NLM ISO Abbreviation: Immunol Invest Subsets: MEDLINE

Low-dose IL-2 restores Tfh/Tfr imbalance and modulates B cell subset distribution in the pre-arthritis phase of the collagen-induced arthritis model.

Authors: Su R Wang H Li B et al.

Source: Clinical rheumatology [Clin Rheumatol] 2025 Jun; Vol. 44 (6), pp. 2487-2500. Date of Electronic Publication: 2025 Apr 30.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 8211469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1434-9949 (Electronic) Linking ISSN: 07703198 NLM ISO Abbreviation: Clin Rheumatol Subsets: MEDLINE

Facile induction of immune tolerance by an interleukin-2-TGFβ surrogate agonist.

Authors: Sun Q Barrett AK Ogishi M et al.

Source: Nature [Nature] 2026 May; Vol. 653 (8115), pp. 888-899. Date of Electronic Publication: 2026 Mar 11.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

Dual PD-1/IL-2Rα targeting restores CD8⁺ T cell fitness via STAT5/CD47 axis in SMARCA4-deficient NSCLC.

Authors: Shang X Cheng B Li Z et al.

Source: Cell reports. Medicine [Cell Rep Med] 2026 Mar 17; Vol. 7 (3), pp. 102633. Date of Electronic Publication: 2026 Feb 20.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE

WTX-124, a Conditionally Activated Wild-Type IL2, Maximizes the Therapeutic Index of IL2, Unlike "Non-Alpha" Muteins.

Authors: Nirschl CJ Subramanian KK Brodkin HR et al.

Source: Cancer immunology research [Cancer Immunol Res] 2026 Mar 04; Vol. 14 (3), pp. 434-449.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101614637 Publication Model: Print Cited Medium: Internet ISSN: 2326-6074 (Electronic) Linking ISSN: 23266066 NLM ISO Abbreviation: Cancer Immunol Res Subsets: MEDLINE

Gene-corrected regulatory T cell therapy for IL2RA deficiency.

Authors: Ha AS Kalter N Rosenberg M et al.

Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Mar 04; Vol. 34 (3), pp. 1367-1381. Date of Electronic Publication: 2025 Dec 09.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

[Biological activity and antitumor effect of long-acting recombinant human interleukin-2 drug].

Authors: Liang X Zhang F Jin T et al.

Source: Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences [Beijing Da Xue Xue Bao Yi Xue Ban] 2025 Apr 18; Vol. 57 (2), pp. 253-261.

Publication Type: English Abstract; Journal Article

Journal Info: Publisher: Beijing da xue Country of Publication: China NLM ID: 101125284 Publication Model: Print Cited Medium: Print ISSN: 1671-167X (Print) Linking ISSN: 1671167X NLM ISO Abbreviation: Beijing Da Xue Xue Bao Yi Xue Ban Subsets: MEDLINE

Immunosuppressive effects of triptolide via interleukin-2/receptor signaling.

Authors: Xiong Y Yin Y Darshika Kodithuwakku N et al.

Source: Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2024 Dec; Vol. 46 (6), pp. 727-740. Date of Electronic Publication: 2024 Sep 17.

Publication Type: Journal Article

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8800150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2513 (Electronic) Linking ISSN: 08923973 NLM ISO Abbreviation: Immunopharmacol Immunotoxicol Subsets: MEDLINE

Antigen-scaffolds loaded with hyper-stable neoleukin-2/15 expand antigen-specific T cells with a favorable phenotype for adoptive cell therapy.

Authors: Ormhøj M Munk KK Tvingsholm S et al.

Source: Frontiers in immunology [Front Immunol] 2026 Jun 11; Vol. 17, pp. 1804678. Date of Electronic Publication: 2026 Jun 11 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Soluble IL-2 receptor and memory Treg profiles differentiate early rheumatoid arthritis from undifferentiated arthritis at initial presentation.

Authors: Zi X Shi Y Zhao Y et al.

Source: Frontiers in immunology [Front Immunol] 2026 Jun 09; Vol. 17, pp. 1844268. Date of Electronic Publication: 2026 Jun 09 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Cutaneous Eruptions and Lifileucel/Interleukin 2 in Individuals With Metastatic Melanoma.

Authors: Said JT Li Y Sadeghi N et al.

Source: JAMA dermatology [JAMA Dermatol] 2026 Jun 01; Vol. 162 (6), pp. 607-612.

Publication Type: Journal Article

Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589530 Publication Model: Print Cited Medium: Internet ISSN: 2168-6084 (Electronic) Linking ISSN: 21686068 NLM ISO Abbreviation: JAMA Dermatol Subsets: MEDLINE

Costimulation loss enhances IL-2-driven Treg generation by PI3K-STAT3 inhibition in CNS autoimmunity.

Authors: Nam KH Kim GR Kim YR et al.

Source: EMBO molecular medicine [EMBO Mol Med] 2026 Jun; Vol. 18 (6), pp. 2272-2292. Date of Electronic Publication: 2026 May 05.

Publication Type: Journal Article

Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE

B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25⁺ age-associated B cells.

Authors: Gauthier J Maugendre M Léonard S et al.

Source: Immunity [Immunity] 2026 Feb 10; Vol. 59 (2), pp. 354-371.e9. Date of Electronic Publication: 2026 Jan 30.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE

CD301b⁺ dendritic cell-derived IL-2 dictates CD4⁺ T helper cell differentiation.

Authors: Tatsumi N El-Fenej J Davila-Pagan A et al.

Source: Nature communications [Nat Commun] 2025 Feb 26; Vol. 16 (1), pp. 2002. Date of Electronic Publication: 2025 Feb 26.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

IL-2 mutein promotes antigen-specific transplant acceptance in mice through expansion of ST2⁺ regulatory T cells.

Authors: Ganchiku Y Ribas GT Lima K et al.

Source: Nature communications [Nat Commun] 2026 Jun 22; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 22.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Genetic evidence for efficacy of targeting IL-2, IL-6 and TYK2 signalling in the prevention of type 1 diabetes: a Mendelian randomisation study.

Authors: Heikkilä TE Kaiser EK Lin J et al.

Source: Diabetologia [Diabetologia] 2024 Dec; Vol. 67 (12), pp. 2667-2677. Date of Electronic Publication: 2024 Sep 13.

Publication Type: Journal Article

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE

DF6215, an α-optimized IL-2-Fc fusion, expands immune effectors and drives robust preclinical anti-tumor activity.

Authors: Stockmann AP Vincent S Herschelman L et al.

Source: Cell reports. Medicine [Cell Rep Med] 2026 Jan 20; Vol. 7 (1), pp. 102518. Date of Electronic Publication: 2025 Dec 29.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE

Ocrelizumab modulates the IL-2 signaling pathway and associated lncRNAs in multiple sclerosis.

Authors: Rangani F Nahayati MA Pahlevan Kakhki M et al.

Source: Journal of the neurological sciences [J Neurol Sci] 2026 Jan 15; Vol. 480, pp. 125693. Date of Electronic Publication: 2025 Dec 11.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375403 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5883 (Electronic) Linking ISSN: 0022510X NLM ISO Abbreviation: J Neurol Sci Subsets: MEDLINE