Search Results - "Kerchner GA"

Plasma phosphorylated tau 217 detects amyloid-β in neuronal synuclein disease.

Authors: Smith AM Lorkiewicz SA Arslan B et al.

Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2026 Apr 10; Vol. 12 (1). Date of Electronic Publication: 2026 Apr 10.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE

Efficacy and safety of intravenous prasinezumab in individuals with early-stage Parkinson's disease on stable symptomatic monotherapy (PADOVA): a phase 2b, multicentre, randomised, double-blind, placebo-controlled study.

Authors: Nikolcheva T Pagano G Anzures-Cabrera J et al.

Corporate Authors: Nikolcheva T Pagano G Anzures-Cabrera J et al.

Source: Lancet (London, England) [Lancet] 2026 May 30; Vol. 407 (10544), pp. 2227-2240.

Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase II

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE

Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.

Authors: Wilson EN Umans J Swarovski MS et al.

Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2025 Apr 26; Vol. 11 (1), pp. 96. Date of Electronic Publication: 2025 Apr 26.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE

Plasma Aβ42/Aβ40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum.

Authors: Trelle AN Young CB Vossler H et al.

Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2025 Feb; Vol. 21 (2), pp. e14442. Date of Electronic Publication: 2024 Dec 23.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

Biologically defined neuronal synuclein disease as a tool to advance drug development.

Authors: Pagano G Dam T Kerchner GA et al.

Source: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2024 Dec 20; Vol. 10 (1), pp. 235. Date of Electronic Publication: 2024 Dec 20.

Publication Type: Letter

Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE

Plasma pTau181 Reveals a Pathological Signature that Predicts Cognitive Outcomes in Lewy Body Disease.

Authors: Abdelnour C Young CB Shahid-Besanti M et al.

Source: Annals of neurology [Ann Neurol] 2024 Sep; Vol. 96 (3), pp. 526-538. Date of Electronic Publication: 2024 Jun 18.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE

Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson's disease.

Authors: Rutledge J Lehallier B Zarifkar P et al.

Source: Acta neuropathologica [Acta Neuropathol] 2024 Mar 11; Vol. 147 (1), pp. 52. Date of Electronic Publication: 2024 Mar 11.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE

Synergistic effects of APOE ε4 and Alzheimer's pathology on the neural correlates of episodic remembering in cognitively unimpaired older adults.

Authors: Trelle AN Sheng J Wilson EN et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jun 25. Date of Electronic Publication: 2025 Jun 25.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Decision making in clinical trials: Interim analyses, innovative design, and biomarkers.

Authors: Welsh-Bohmer KA Kerchner GA Dhadda S et al.

Source: Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2023 Oct 18; Vol. 9 (4), pp. e12421. Date of Electronic Publication: 2023 Oct 18 (Print Publication: 2023).

Publication Type: Journal Article

Journal Info: Publisher: Wiley on behalf of the Alzheimer's Association Country of Publication: United States NLM ID: 101650118 Publication Model: eCollection Cited Medium: Internet ISSN: 2352-8737 (Electronic) Linking ISSN: 23528737 NLM ISO Abbreviation: Alzheimers Dement (N Y) Subsets: PubMed not MEDLINE

Development of a quantitative semi-mechanistic model of Alzheimer's disease based on the amyloid/tau/neurodegeneration framework (the Q-ATN model).

Authors: Mazer NA Hofmann C Lott D et al.

Corporate Authors: Mazer NA Hofmann C Lott D et al.

Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 Jun; Vol. 19 (6), pp. 2287-2297. Date of Electronic Publication: 2022 Dec 01.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't

Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial.

Authors: Bateman RJ Li Y McDade EM et al.

Corporate Authors: Bateman RJ Li Y McDade EM et al.

Source: The Lancet. Neurology [Lancet Neurol] 2025 Apr; Vol. 24 (4), pp. 316-330.

Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III; Clinical Trial, Phase II

Journal Info: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 101139309 Publication Model: Print Cited Medium: Internet ISSN: 1474-4465 (Electronic) Linking ISSN: 14744422 NLM ISO Abbreviation: Lancet Neurol Subsets: MEDLINE

Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU Trial.

Authors: Bateman RJ Li Y McDade EM et al.

Corporate Authors: Bateman RJ Li Y McDade EM et al.

Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Jan 29. Date of Electronic Publication: 2025 Jan 29.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE

Long-term safety of gantenerumab in participants with Alzheimer's disease: A phase III, open-label extension study (SCarlet RoAD).

Authors: Boada M Neve A Das B et al.

Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2025 Jan; Vol. 103 (2), pp. 528-541. Date of Electronic Publication: 2024 Dec 16.

Publication Type: Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial; Multicenter Study; Research Support, Non-U.S. Gov't

Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 9814863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE

Evaluation of dose-dependent treatment effects after mid-trial dose escalation in biomarker, clinical, and cognitive outcomes for gantenerumab or solanezumab in dominantly inherited Alzheimer's disease.

Authors: Wang G Li Y Xiong C et al.

Corporate Authors: Wang G Li Y Xiong C et al.

Source: Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2022 Nov 03; Vol. 14 (1), pp. e12367. Date of Electronic Publication: 2022 Nov 03 (Print Publication: 2022).

Publication Type: Journal Article

Journal Info: Publisher: Wiley on behalf of the Alzheimer's Association Country of Publication: United States NLM ID: 101654604 Publication Model: eCollection Cited Medium: Print ISSN: 2352-8729 (Print) Linking ISSN: 23528729 NLM ISO Abbreviation: Alzheimers Dement (Amst) Subsets: PubMed not MEDLINE

Sustained effect of prasinezumab on Parkinson's disease motor progression in the open-label extension of the PASADENA trial.

Authors: Pagano G Monnet A Reyes A et al.

Corporate Authors: Pagano G Monnet A Reyes A et al.

Source: Nature medicine [Nat Med] 2024 Dec; Vol. 30 (12), pp. 3669-3675. Date of Electronic Publication: 2024 Oct 08.

Publication Type: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial

Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease: A Randomized Clinical Trial.

Authors: Teng E Manser PT Pickthorn K et al.

Corporate Authors: Teng E Manser PT Pickthorn K et al.

Source: JAMA neurology [JAMA Neurol] 2022 Aug 01; Vol. 79 (8), pp. 758-767.

Publication Type: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE

Safety, Tolerability, and Pharmacokinetics of High-Volume Subcutaneous Crenezumab, With and Without Recombinant Human Hyaluronidase in Healthy Volunteers.

Authors: Dolton MJ Chesterman A Moein A et al.

Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 Nov; Vol. 110 (5), pp. 1337-1348. Date of Electronic Publication: 2021 Aug 27.

Publication Type: Clinical Trial, Phase I; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

Multiple biomarkers improve diagnostic accuracy across Lewy body and Alzheimer's disease spectra.

Authors: Plastini MJ Abdelnour C Young CB et al.

Source: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2024 May; Vol. 11 (5), pp. 1197-1210. Date of Electronic Publication: 2024 Mar 04.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Wiley Periodicals, Inc on behalf of American Neurological Association Country of Publication: United States NLM ID: 101623278 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2328-9503 (Electronic) Linking ISSN: 23289503 NLM ISO Abbreviation: Ann Clin Transl Neurol Subsets: MEDLINE

Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson's disease.

Authors: Pagano G Taylor KI Anzures Cabrera J et al.

Corporate Authors: Pagano G Taylor KI Anzures Cabrera J et al.

Source: Nature medicine [Nat Med] 2024 Apr; Vol. 30 (4), pp. 1096-1103. Date of Electronic Publication: 2024 Apr 15.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

Evaluation of partial volume correction and analysis of longitudinal [¹⁸F]GTP1 tau PET imaging in Alzheimer's disease using linear mixed-effects models.

Authors: Sanabria Bohórquez SM Baker S Manser PT et al.

Source: Frontiers in neuroimaging [Front Neuroimaging] 2024 Mar 28; Vol. 3, pp. 1355402. Date of Electronic Publication: 2024 Mar 28 (Print Publication: 2024).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 9918402387106676 Publication Model: eCollection Cited Medium: Internet ISSN: 2813-1193 (Electronic) Linking ISSN: 28131193 NLM ISO Abbreviation: Front Neuroimaging Subsets: PubMed not MEDLINE