Search Results - "Klimtchuk ES"

Small Molecule Stabilization of Diverse Amyloidogenic Immunoglobulin Light Chains Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry.

Authors: Peterle D Yan NL Klimtchuk ES et al.

Source: Journal of molecular biology [J Mol Biol] 2026 Jun 29; Vol. 438 (19), pp. 169917. Date of Electronic Publication: 2026 Jun 29.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

Structural Basis for the Pro-amyloidogenic Action and Ligand Binding of a Novel W72R Variant of Human Apolipoprotein A-I.

Authors: Prokaeva T Jayaraman S Klimtchuk ES et al.

Source: Journal of molecular biology [J Mol Biol] 2026 Jun 24; Vol. 438 (19), pp. 169916. Date of Electronic Publication: 2026 Jun 24.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

Small molecule stabilization of diverse amyloidogenic immunoglobulin light chains revealed by hydrogen-deuterium exchange mass spectrometry.

Authors: Peterle D Yan NL Klimtchuk ES et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 08. Date of Electronic Publication: 2026 Jan 08.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Role of complementarity-determining regions 1 and 3 in pathologic amyloid formation by human immunoglobulin κ1 light chains.

Authors: Klimtchuk ES Peterle D Bullitt E et al.

Source: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis [Amyloid] 2023 Dec; Vol. 30 (4), pp. 364-378. Date of Electronic Publication: 2023 May 22.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9433802 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-2818 (Electronic) Linking ISSN: 13506129 NLM ISO Abbreviation: Amyloid Subsets: MEDLINE

An additive destabilising effect of compound T60I and V122I substitutions in ATTRv amyloidosis.

Authors: Prokaeva T Klimtchuk ES Feschenko P et al.

Source: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis [Amyloid] 2023 Jun; Vol. 30 (2), pp. 141-152. Date of Electronic Publication: 2022 Oct 26.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9433802 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-2818 (Electronic) Linking ISSN: 13506129 NLM ISO Abbreviation: Amyloid Subsets: MEDLINE

A novel substitution of proline (P32L) destabilises β2-microglobulin inducing hereditary systemic amyloidosis.

Authors: Prokaeva T Joshi T Klimtchuk ES et al.

Source: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis [Amyloid] 2022 Dec; Vol. 29 (4), pp. 255-262. Date of Electronic Publication: 2022 May 14.

Publication Type: Case Reports; Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9433802 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-2818 (Electronic) Linking ISSN: 13506129 NLM ISO Abbreviation: Amyloid Subsets: MEDLINE

Conformational Differences in the Light Chain Constant Domain of Immunoglobulin G and Free Light Chain May Influence Proteolysis in AL Amyloidosis.

Authors: Klimtchuk ES Prokaeva T Spencer BH et al.

Source: Journal of molecular biology [J Mol Biol] 2024 Dec 01; Vol. 436 (23), pp. 168837. Date of Electronic Publication: 2024 Oct 28.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

Role of Complementarity-Determining Regions 1 and 3 in Pathologic Amyloid Formation by Human Immunoglobulin κ1 Light Chains.

Authors: Klimtchuk ES Peterle D Bullitt EA et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2023 Feb 03. Date of Electronic Publication: 2023 Feb 03.

Publication Type: Preprint; Journal Article

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

A Conservative Point Mutation in a Dynamic Antigen-binding Loop of Human Immunoglobulin λ6 Light Chain Promotes Pathologic Amyloid Formation.

Authors: Peterle D Klimtchuk ES Wales TE et al.

Source: Journal of molecular biology [J Mol Biol] 2021 Dec 03; Vol. 433 (24), pp. 167310. Date of Electronic Publication: 2021 Oct 19.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis.

Authors: Klimtchuk ES Prokaeva TB Spencer BH et al.

Source: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis [Amyloid] 2017 Jun; Vol. 24 (2), pp. 115-122. Date of Electronic Publication: 2017 Jun 20.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9433802 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-2818 (Electronic) Linking ISSN: 13506129 NLM ISO Abbreviation: Amyloid Subsets: MEDLINE

Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease.

Authors: Klimtchuk ES Prokaeva T Frame NM et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Jul 10; Vol. 115 (28), pp. E6428-E6436. Date of Electronic Publication: 2018 Jun 25.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Cooperative stabilization of transthyretin by clusterin and diflunisal.

Authors: Greene MJ Klimtchuk ES Seldin DC et al.

Source: Biochemistry [Biochemistry] 2015 Jan 20; Vol. 54 (2), pp. 268-78. Date of Electronic Publication: 2014 Dec 24.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain.

Authors: Klimtchuk ES Gursky O Patel RS et al.

Source: Biochemistry [Biochemistry] 2010 Nov 16; Vol. 49 (45), pp. 9848-57. Date of Electronic Publication: 2010 Oct 20.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugation.

Authors: Kingsbury JS Laue TM Klimtchuk ES et al.

Source: The Journal of biological chemistry [J Biol Chem] 2008 May 02; Vol. 283 (18), pp. 11887-96. Date of Electronic Publication: 2008 Mar 06.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Print ISSN: 0021-9258 (Print) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Expression, purification, and in vitro cysteine-10 modification of native sequence recombinant human transthyretin.

Authors: Kingsbury JS Klimtchuk ES Théberge R et al.

Source: Protein expression and purification [Protein Expr Purif] 2007 Jun; Vol. 53 (2), pp. 370-7. Date of Electronic Publication: 2007 Jan 17.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9101496 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1046-5928 (Print) Linking ISSN: 10465928 NLM ISO Abbreviation: Protein Expr Purif Subsets: MEDLINE

Changes in structure and stability of calbindin-D(28K) upon calcium binding.

Authors: Venyaminov SY Klimtchuk ES Bajzer Z et al.

Source: Analytical biochemistry [Anal Biochem] 2004 Nov 01; Vol. 334 (1), pp. 97-105.

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0370535 Publication Model: Print Cited Medium: Print ISSN: 0003-2697 (Print) Linking ISSN: 00032697 NLM ISO Abbreviation: Anal Biochem Subsets: MEDLINE

The metal-binding properties of DREAM: evidence for calcium-mediated changes in DREAM structure.

Authors: Craig TA Benson LM Venyaminov SY et al.

Source: The Journal of biological chemistry [J Biol Chem] 2002 Mar 29; Vol. 277 (13), pp. 10955-66. Date of Electronic Publication: 2002 Jan 11.

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Print ISSN: 0021-9258 (Print) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE