Search Results - "Labroli M"

Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In Vivo Efficacy.

Authors: Skudlarek JW Cooke AJ Mitchell HJ et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Sep 12; Vol. 67 (17), pp. 15620-15675. Date of Electronic Publication: 2024 Aug 22.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure-Activity Relationships.

Authors: Plotkin MA Labroli M Schubert J et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Jul 09; Vol. 15 (8), pp. 1232-1241. Date of Electronic Publication: 2024 Jul 09 (Print Publication: 2024).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii.

Authors: Wang H Ishchenko A Skudlarek J et al.

Source: Nature microbiology [Nat Microbiol] 2024 May; Vol. 9 (5), pp. 1244-1255. Date of Electronic Publication: 2024 Apr 22.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE

Lead Optimization to Advance Protease-Activated Receptor-1 Antagonists in Early Discovery.

Authors: Mandal M Madeira M Amin RP et al.

Source: Journal of medicinal chemistry [J Med Chem] 2022 Apr 14; Vol. 65 (7), pp. 5575-5592. Date of Electronic Publication: 2022 Mar 29.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase.

Authors: Walker SS Labroli M Painter RE et al.

Source: PloS one [PLoS One] 2017 Jul 10; Vol. 12 (7), pp. e0180965. Date of Electronic Publication: 2017 Jul 10 (Print Publication: 2017).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets.

Authors: Mann PA Müller A Wolff KA et al.

Source: PLoS pathogens [PLoS Pathog] 2016 May 04; Vol. 12 (5), pp. e1005585. Date of Electronic Publication: 2016 May 04 (Print Publication: 2016).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.

Authors: Lee SH Wang H Labroli M et al.

Source: Science translational medicine [Sci Transl Med] 2016 Mar 09; Vol. 8 (329), pp. 329ra32.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles.

Authors: Sanders JM Beshore DC Culberson JC et al.

Source: Journal of medicinal chemistry [J Med Chem] 2017 Aug 24; Vol. 60 (16), pp. 6771-6780. Date of Electronic Publication: 2017 May 05.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.

Authors: Mandal M Tan Z Madsen-Duggan C et al.

Source: Journal of medicinal chemistry [J Med Chem] 2017 May 11; Vol. 60 (9), pp. 3851-3865. Date of Electronic Publication: 2017 Mar 29.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS.

Authors: Berejnaia O Wang H Labroli M et al.

Source: Analytical biochemistry [Anal Biochem] 2017 Feb 01; Vol. 518, pp. 9-15. Date of Electronic Publication: 2016 Nov 02.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0370535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0309 (Electronic) Linking ISSN: 00032697 NLM ISO Abbreviation: Anal Biochem Subsets: MEDLINE

Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus.

Authors: Yang SW Pan J Yang C et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Oct 01; Vol. 26 (19), pp. 4743-4747. Date of Electronic Publication: 2016 Aug 16.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

NMR Binding and Functional Assays for Detecting Inhibitors of S. aureus MnaA.

Authors: Hou Y Mayhood T Sheth P et al.

Source: Journal of biomolecular screening [J Biomol Screen] 2016 Jul; Vol. 21 (6), pp. 579-89. Date of Electronic Publication: 2016 Mar 29.

Publication Type: Journal Article

Journal Info: Publisher: Sage Publications Country of Publication: United States NLM ID: 9612112 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-454X (Electronic) Linking ISSN: 10870571 NLM ISO Abbreviation: J Biomol Screen Subsets: MEDLINE

Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme MurG.

Authors: Mann PA Müller A Xiao L et al.

Source: ACS chemical biology [ACS Chem Biol] 2013 Nov 15; Vol. 8 (11), pp. 2442-51. Date of Electronic Publication: 2013 Sep 05.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: a template-based approach.

Authors: Dwyer MP Keertikar K Paruch K et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Nov 15; Vol. 23 (22), pp. 6178-82. Date of Electronic Publication: 2013 Sep 07.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening.

Authors: Guzi TJ Paruch K Dwyer MP et al.

Source: Molecular cancer therapeutics [Mol Cancer Ther] 2011 Apr; Vol. 10 (4), pp. 591-602. Date of Electronic Publication: 2011 Feb 14.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: a template-based approach--part 2.

Authors: Labroli M Paruch K Dwyer MP et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Jan 01; Vol. 21 (1), pp. 471-4. Date of Electronic Publication: 2010 Oct 28.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: a template-based approach--part 1.

Authors: Dwyer MP Paruch K Labroli M et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Jan 01; Vol. 21 (1), pp. 467-70. Date of Electronic Publication: 2010 Oct 27.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

The synthesis of amino-acid functionalized beta-carbolines as topoisomerase II inhibitors.

Authors: Deveau AM Labroli MA Dieckhaus CM et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2001 May 21; Vol. 11 (10), pp. 1251-5.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase.

Authors: Boger DL Labroli MA Marsilje TH et al.

Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2000 May; Vol. 8 (5), pp. 1075-86.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print Cited Medium: Print ISSN: 0968-0896 (Print) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

The synthesis and evaluation of benzannelated-azatoxins: the benzazatoxins.

Authors: Miller TA Vachaspati PR Labroli MA et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1998 May 05; Vol. 8 (9), pp. 1065-70.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE