Search Results - "Lessard, Samuel"

Leveraging large-scale multi-omics evidences to identify therapeutic targets from genome-wide association studies.

Authors: Lessard, Samuel Chao, Michael Reis, Kadri et al.

Source: BMC Genomics. 11/19/2024, Vol. 25 Issue 1, p1-16. 16p.

Zinc finger nuclease-mediated gene editing in hematopoietic stem cells results in reactivation of fetal hemoglobin in sickle cell disease.

Authors: Lessard, Samuel Rimmelé, Pauline Ling, Hui et al.

Source: Scientific Reports. 10/16/2024, Vol. 14 Issue 1, p1-18. 18p.

An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level.

Authors: Bauer, Daniel E. Kamran, Sophia C. Lessard, Samuel et al.

Source: Science (pre-March 2025). 10/11/2013, Vol. 342 Issue 6155, preceding p253-257. 6p.

Subjects: Hemoglobinopathy, Erythrocyte membranes, Transcription factors, Fetus, Genetics, Chromatin, Gene expression, B cells, Health

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Building a human genetic data lake to scale up insights for drug discovery.

Authors: Chatelain, Clement Lessard, Samuel Klinger, Katherine et al.

Source: Drug Discovery Today. Jun2025, Vol. 30 Issue 6, pN.PAG-N.PAG. 1p.

Selective AMPKβ1 activation induces fetal hemoglobin in human erythroid cells and sickle cell mice via the noncanonical NRF2 pathway.

Authors: Hara, Yannis Lemgart, Viktor T. Lessard, Samuel et al.

Source: Science Advances. 11/21/2025, Vol. 11 Issue 47, p1-21. 21p.

Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci.

Authors: Lessard, Samuel Tardif, Jean-Claude Lettre, Guillaume et al.

Source: Proceedings of the National Academy of Sciences of the United States of America. 12/26/2017, Vol. 114 Issue 52, p11257-11266. 10p.

Subjects: CRISPRs, Human genetic variation, Locus (Genetics), Genome editing, Single nucleotide polymorphisms

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An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility.

Authors: Lessard, Samuel Gatof, Emily Stern Beaudoin, Mélissa et al.

Source: Journal of Clinical Investigation. Aug2017, Vol. 127 Issue 8, p3065-3074. 10p.

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Frameshift indels introduced by genome editing can lead to in-frame exon skipping.

Authors: Lalonde, Simon Stone, Oliver A. Lessard, Samuel et al.

Source: PLoS ONE. 6/1/2017, Vol. 12 Issue 6, p1-13. 13p.

Lower Methylation of the ANGPTL2 Gene in Leukocytes from Post-Acute Coronary Syndrome Patients.

Authors: Nguyen, Albert Mamarbachi, Maya Turcot, Valérie et al.

Source: PLoS ONE. 4/21/2016, Vol. 11 Issue 4, p1-17. 17p.

The Human Pleiotropic Map of GWAS Associations and Therapeutic Implications.

Authors: Tsepilov YA Suveges D Considine D et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 01. Date of Electronic Publication: 2026 May 01.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Genetic liability to psoriasis predicts severe disease outcomes.

Authors: Saklatvala JR Lessard S Teder-Laving M et al.

Corporate Authors: Saklatvala JR Lessard S Teder-Laving M et al.

Source: Genome medicine [Genome Med] 2025 Dec 17; Vol. 18 (1), pp. 14. Date of Electronic Publication: 2025 Dec 17.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE

Genetic analyses of inflammatory polyneuropathy and chronic inflammatory demyelinating polyradiculoneuropathy identified candidate genes.

Authors: Du Z Lessard S Iyyanki T et al.

Source: HGG advances [HGG Adv] 2024 Jul 18; Vol. 5 (3), pp. 100317. Date of Electronic Publication: 2024 Jun 08.

Publication Type: Journal Article; Meta-Analysis

Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101772885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-2477 (Electronic) Linking ISSN: 26662477 NLM ISO Abbreviation: HGG Adv Subsets: MEDLINE

Genome-wide association study analysis of disease severity in Acne reveals novel biological insights.

Authors: Du Z Iyyanki T Lessard S et al.

Corporate Authors: Du Z Iyyanki T Lessard S et al.

Source: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Nov 14. Date of Electronic Publication: 2023 Nov 14.

Publication Type: Preprint; Journal Article

Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE

SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells.

Authors: Hara Y Lemgart VT Halland N et al.

Source: Blood advances [Blood Adv] 2023 Jun 13; Vol. 7 (11), pp. 2317-2323.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE

14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts.

Authors: Lessard S Beaudoin M Orkin SH et al.

Source: Human molecular genetics [Hum Mol Genet] 2018 Apr 15; Vol. 27 (8), pp. 1411-1420.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

Genome-Wide Association Study and Gene-Based Analysis of Participants With Hemophilia A and Inhibitors in the My Life, Our Future Research Repository.

Authors: Lessard S He C Rajpal DK et al.

Source: Frontiers in medicine [Front Med (Lausanne)] 2022 Jun 23; Vol. 9, pp. 903838. Date of Electronic Publication: 2022 Jun 23 (Print Publication: 2022).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101648047 Publication Model: eCollection Cited Medium: Print ISSN: 2296-858X (Print) Linking ISSN: 2296858X NLM ISO Abbreviation: Front Med (Lausanne) Subsets: PubMed not MEDLINE

Testing the role of predicted gene knockouts in human anthropometric trait variation.

Authors: Lessard S Manning AK Low-Kam C et al.

Corporate Authors: Lessard S Manning AK Low-Kam C et al.

Source: Human molecular genetics [Hum Mol Genet] 2016 May 15; Vol. 25 (10), pp. 2082-2092. Date of Electronic Publication: 2016 Feb 21.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE