Search Results - "Lessard CB"

Progressive Supranuclear Palsy PERK Haplotype B Selectively Translates DLX1 Promoting Tau Toxicity.

Authors: Lessard CB Rubio Rubio D Tolton S et al.

Source: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2026 Apr 01; Vol. 46 (13). Date of Electronic Publication: 2026 Apr 01.

Publication Type: Journal Article

Journal Info: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity.

Authors: Lessard CB Rubio-Rubio D Tolton S et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jul 04. Date of Electronic Publication: 2025 Jul 04.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions.

Authors: Croft CL Goodwin MS Ryu DH et al.

Source: Acta neuropathologica [Acta Neuropathol] 2021 Mar; Vol. 141 (3), pp. 359-381. Date of Electronic Publication: 2021 Jan 26.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE

High-affinity interactions and signal transduction between Aβ oligomers and TREM2.

Authors: Lessard CB Malnik SL Zhou Y et al.

Source: EMBO molecular medicine [EMBO Mol Med] 2018 Nov; Vol. 10 (11).

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE

Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways.

Authors: Ibanez KR McFarland KN Phillips J et al.

Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2022 Jul 27; Vol. 14 (1), pp. 104. Date of Electronic Publication: 2022 Jul 27.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE

γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.

Authors: Ran Y Hossain F Pannuti A et al.

Source: EMBO molecular medicine [EMBO Mol Med] 2017 Jul; Vol. 9 (7), pp. 950-966.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP).

Authors: Lessard CB Cottrell BA Maruyama H et al.

Source: PloS one [PLoS One] 2015 Dec 17; Vol. 10 (12), pp. e0144758. Date of Electronic Publication: 2015 Dec 17 (Print Publication: 2015).

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

A nuclear function for the presenilin 1 neuronal partner NPRAP/δ-catenin.

Authors: Koutras C Lessard CB Lévesque G

Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2011; Vol. 27 (2), pp. 307-16.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.

Authors: Lessard CB Rodriguez E Ladd TB et al.

Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2020 May 19; Vol. 12 (1), pp. 61. Date of Electronic Publication: 2020 May 19.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE

Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.

Authors: Lessard CB Rodriguez E Ladd TB et al.

Source: The Journal of biological chemistry [J Biol Chem] 2019 Jul 19; Vol. 294 (29), pp. 11276-11285. Date of Electronic Publication: 2019 Jun 05.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph.

Authors: Magno L Lessard CB Martins M et al.

Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2019 Feb 02; Vol. 11 (1), pp. 16. Date of Electronic Publication: 2019 Feb 02.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE

Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.

Authors: Sagi SA Lessard CB Winden KD et al.

Source: The Journal of biological chemistry [J Biol Chem] 2011 Nov 18; Vol. 286 (46), pp. 39794-803. Date of Electronic Publication: 2011 Aug 25.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

And four equals one: presenilin takes the gamma-secretase role by itself.

Authors: Lessard CB Wagner SL Koo EH

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2010 Dec 14; Vol. 107 (50), pp. 21236-7. Date of Electronic Publication: 2010 Dec 06.

Publication Type: Comment; Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells.

Authors: Lessard CB Lussier MP Cayouette S et al.

Source: Cellular signalling [Cell Signal] 2005 Apr; Vol. 17 (4), pp. 437-45.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print Cited Medium: Print ISSN: 0898-6568 (Print) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE