Search Results - "Lessene G"

Effects of modulators of Ca²⁺-activated, intermediate-conductance potassium channels on motility of the rat small intestine, in vivo.

Authors: Ferens, D. Baell, J. Lessene, G. et al.

Source: Neurogastroenterology & Motility. May2007, Vol. 19 Issue 5, p383-389. 7p. 4 Graphs.

Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway.

Authors: Roy, M J Vom, A Czabotar, P E et al.

Source: British Journal of Pharmacology. Apr2014, Vol. 171 Issue 8, p1973-1987. 15p.

Emerging challenges, mechanisms, and therapeutic opportunities in cell death.

Authors: Dixon SJ Kroemer G Lessene G et al.

Source: Cell chemical biology [Cell Chem Biol] 2026 Jul 16; Vol. 33 (7), pp. 889-891.

Publication Type: Editorial

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

BCL-2 and MCL1 co-inhibition enhances glucocorticoid therapy in preclinical models of infant KMT2A-rearranged acute lymphoblastic leukaemia.

Authors: Karsa M Karsa A Spurling D et al.

Source: British journal of haematology [Br J Haematol] 2026 Jun 05. Date of Electronic Publication: 2026 Jun 05.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE

Divergent resistance pathways amongst SARS-CoV-2 PLpro inhibitors highlight the need for scaffold diversity.

Authors: Wu X Devine SM Go M et al.

Source: PLoS pathogens [PLoS Pathog] 2025 Sep 05; Vol. 21 (9), pp. e1013468. Date of Electronic Publication: 2025 Sep 05 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

The benchmarking and application of tag-degraders in vivo to validate therapeutic targets.

Authors: Magtoto CM Mieruszynski S Dong H et al.

Source: Nature communications [Nat Commun] 2026 May 29; Vol. 17 (1). Date of Electronic Publication: 2026 May 29.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.

Authors: M Bader S Calleja DJ Devine SM et al.

Source: Nature communications [Nat Commun] 2025 Apr 03; Vol. 16 (1), pp. 2900. Date of Electronic Publication: 2025 Apr 03.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Improved drug target deconvolution with PISA-DIA using an extended, overlapping temperature gradient.

Authors: Emery-Corbin SJ Yousef JM Adhikari S et al.

Source: Proteomics [Proteomics] 2024 Aug; Vol. 24 (16), pp. e2300644. Date of Electronic Publication: 2024 May 20.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101092707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-9861 (Electronic) Linking ISSN: 16159853 NLM ISO Abbreviation: Proteomics Subsets: MEDLINE

Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis.

Authors: Yuan Z van Delft MF Li MX et al.

Source: PLoS biology [PLoS Biol] 2024 May 02; Vol. 22 (5), pp. e3002617. Date of Electronic Publication: 2024 May 02 (Print Publication: 2024).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteins.

Authors: Gong JN Djajawi TM Moujalled DM et al.

Source: Cell death and differentiation [Cell Death Differ] 2025 Aug; Vol. 32 (8), pp. 1382-1396. Date of Electronic Publication: 2025 Apr 09.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE

Differential regulation of BAX and BAK apoptotic activity revealed by small molecules.

Authors: Li K Yap YQ Moujalled DM et al.

Source: Science advances [Sci Adv] 2025 Mar 07; Vol. 11 (10), pp. eadr8146. Date of Electronic Publication: 2025 Mar 05.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms.

Authors: Grohmann C Magtoto CM Walker JR et al.

Source: Nature communications [Nat Commun] 2022 Apr 19; Vol. 13 (1), pp. 2073. Date of Electronic Publication: 2022 Apr 19.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.

Authors: Jacobsen AV Pierotti CL Lowes KN et al.

Source: Cell death & disease [Cell Death Dis] 2022 Apr 01; Vol. 13 (4), pp. 291. Date of Electronic Publication: 2022 Apr 01.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.

Authors: Meng Y Davies KA Fitzgibbon C et al.

Source: Nature communications [Nat Commun] 2021 Nov 22; Vol. 12 (1), pp. 6783. Date of Electronic Publication: 2021 Nov 22.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Mutational profiling of SARS-CoV-2 papain-like protease reveals requirements for function, structure, and drug escape.

Authors: Wu X Go M Nguyen JV et al.

Source: Nature communications [Nat Commun] 2024 Jul 23; Vol. 15 (1), pp. 6219. Date of Electronic Publication: 2024 Jul 23.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Synthesis and Biological Evaluation of (-) and (+)-Spiroleucettadine and Analogues.

Authors: Badart MP Barnes EM Cording AP et al.

Source: ChemMedChem [ChemMedChem] 2021 Apr 20; Vol. 16 (8), pp. 1308-1315. Date of Electronic Publication: 2021 Jan 26.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors.

Authors: Grohmann C Walker F Devlin M et al.

Source: Cell death & disease [Cell Death Dis] 2021 Mar 12; Vol. 12 (3), pp. 268. Date of Electronic Publication: 2021 Mar 12.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE

BCL-XL exerts a protective role against anemia caused by radiation-induced kidney damage.

Authors: Brinkmann K Waring P Glaser SP et al.

Source: The EMBO journal [EMBO J] 2020 Dec 15; Vol. 39 (24), pp. e105561. Date of Electronic Publication: 2020 Nov 25.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.

Authors: Klemm T Ebert G Calleja DJ et al.

Source: The EMBO journal [EMBO J] 2020 Sep 15; Vol. 39 (18), pp. e106275. Date of Electronic Publication: 2020 Aug 26.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

Defining the susceptibility of colorectal cancers to BH3-mimetic compounds.

Authors: Luo MJ Palmieri M Riffkin CD et al.

Source: Cell death & disease [Cell Death Dis] 2020 Sep 10; Vol. 11 (9), pp. 735. Date of Electronic Publication: 2020 Sep 10.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE