Search Results - "Lessene G"

Divergent resistance pathways amongst SARS-CoV-2 PLpro inhibitors highlight the need for scaffold diversity.

Authors: Wu X Devine SM Go M et al.

Source: PLoS pathogens [PLoS Pathog] 2025 Sep 05; Vol. 21 (9), pp. e1013468. Date of Electronic Publication: 2025 Sep 05 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.

Authors: M Bader S Calleja DJ Devine SM et al.

Source: Nature communications [Nat Commun] 2025 Apr 03; Vol. 16 (1), pp. 2900. Date of Electronic Publication: 2025 Apr 03.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

The effect of combining HIV latency reversal with inhibition of phosphoinositide-3 kinases or B-cell lymphoma-2 on the HIV reservoir.

Authors: Kim, Youry Anderson, Jenny L. Tumpach, Carolin et al.

Source: PLoS Pathogens. 1/29/2025, Vol. 22 Issue 1, p1-21. 21p.

The benchmarking and application of tag-degraders in vivo to validate therapeutic targets.

Authors: Magtoto CM Mieruszynski S Dong H et al.

Source: Nature communications [Nat Commun] 2026 May 29; Vol. 17 (1). Date of Electronic Publication: 2026 May 29.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

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SNAI2 cooperates with MEK1/2 and HDACs to suppress BIM- and BMF-dependent apoptosis in TERT promoter mutant cancers.

Authors: Tandon, Amol Stern, Josh Lewis

Source: PLoS ONE. 6/25/2025, Vol. 20 Issue 6, p1-17. 17p.

The Study of Effects of Monophenolic Antioxidants, Sodium Anphen and Potassium Phenosan, on Cell Apoptosis by Fluorescence and Confocal Microscopy.

Authors: Mil, Elena M. Albantova, Anastasia A. Matienko, Ludmila I. et al.

Source: International Journal of Molecular Sciences. Apr2026, Vol. 27 Issue 8, p3514. 14p.

Puerarin Inhibits Proliferation, Migration and Invasion of Colon Cancer Cells and Induces Apoptosis via Suppression of the PI3K/AKT Signaling Pathway.

Authors: Chen, Lin Li, Xuhong Zhao, Shijie et al.

Source: Pharmaceuticals (14248247). Sep2025, Vol. 18 Issue 9, p1378. 18p.

Reverse engineering of BNIP3 identifies a mitochondrial protective peptide.

Authors: Hendgen-Cotta UB Roth A Beuck C et al.

Source: Nature communications [Nat Commun] 2026 Jun 17; Vol. 17 (1). Date of Electronic Publication: 2026 Jun 17.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Structural Basis and Inhibitor Development of SARS-CoV-2 Papain-like Protease.

Authors: Wang, Junshuai Xu, Yuancong Yang, Yishu et al.

Source: Molecules. Feb2026, Vol. 31 Issue 3, p474. 24p.

ESR1 Regulates Fecundity and Functions in Sheep Endometrial Stromal Cells.

Authors: Li, Kang Gao, Xiaoxiao Wang, Zhibo et al.

Source: International Journal of Molecular Sciences. Dec2025, Vol. 26 Issue 23, p11410. 14p.

Yeast NatB Regulates Cell Death of Bax-Expressing Cells.

Authors: Guedes, Joana P. Mendes, Filipa Machado, Beatriz O. et al.

Source: Biomolecules (2218-273X). Dec2025, Vol. 15 Issue 12, p1731. 13p.

COP1 Deficiency in BRAF V600E Melanomas Confers Resistance to Inhibitors of the MAPK Pathway.

Authors: Ndoja, Ada Rose, Christopher M. Lin, Eva et al.

Source: Cells (2073-4409). Jul2025, Vol. 14 Issue 13, p975. 18p.

Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis.

Authors: Yuan Z van Delft MF Li MX et al.

Source: PLoS biology [PLoS Biol] 2024 May 02; Vol. 22 (5), pp. e3002617. Date of Electronic Publication: 2024 May 02 (Print Publication: 2024).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

Mechanistic Insights Into the Hepatoprotective Effects of Punicalagin Against Oxidative Stress: Involvement of the PI3K/AKT/mTOR Pathway and Autophagy.

Authors: Yang, Xia Xiong, Chuan Zhang, Jing et al.

Source: Journal of Food Biochemistry. 5/30/2026, Vol. 2026, p1-15. 15p.

Subjects: PI3K/AKT/mTOR pathway, Autophagy, Mitochondria, Oxidative stress, Pomegranate, Apoptosis, Liver injuries

Mitochondrial Voltage-Dependent Anion Channel: From a Passive Pore to a Cellular Hub Through Protein Complexation.

Authors: Rajendran, Megha Bezrukov, Sergey M. Rostovtseva, Tatiana K.

Source: International Journal of Molecular Sciences. Jul2026, Vol. 27 Issue 13, p5804. 24p.

Interactomics of SARS-CoV-2 Macrodomain 1 Reveals Putative Clients of ADP-Ribosyl Hydrolase Activity.

Authors: Cameron, Crissey D. Heilmann, Grace Roman, Brynn K. et al.

Source: Viruses (1999-4915). Jun2026, Vol. 18 Issue 6, p587. 18p.

Co-targeting of epigenetic regulators and BCL-XL improves efficacy of immune checkpoint blockade therapy in multiple solid tumors.

Authors: Senent, Yaiza Fresquet, Vicente Jiménez, Victoria et al.

Source: Molecular Cancer. 5/30/2025, Vol. 24 Issue 1, p1-20. 20p.

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First in human phase 1 study of DT2216, a selective BCL-xL degrader, in patients with relapsed/refractory solid malignancies.

Authors: Mahadevan, Daruka Barve, Minal Mahalingam, Devalingam et al.

Source: Journal of Hematology & Oncology. 11/12/2025, Vol. 18 Issue 1, p1-12. 12p.