Search Results - "Lock RB"

Pharmacological inhibition of sclerostin protects bone from B-cell acute lymphoblastic leukemia-mediated destruction.

Authors: Kuek V Oommen J Ferrari E et al.

Source: HemaSphere [Hemasphere] 2026 Mar 31; Vol. 10 (4), pp. e70355. Date of Electronic Publication: 2026 Mar 31 (Print Publication: 2026).

Publication Type: Letter

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101740619 Publication Model: eCollection Cited Medium: Internet ISSN: 2572-9241 (Electronic) Linking ISSN: 25729241 NLM ISO Abbreviation: Hemasphere Subsets: PubMed not MEDLINE

Preclinical evaluation of the ROR1-targeting antibody-drug conjugates zilovertamab vedotin and VLS-211 against B-cell ALL patient-derived xenografts.

Authors: Smith CM Watts B Evans K et al.

Source: HemaSphere [Hemasphere] 2026 Jul 22; Vol. 10 (7), pp. e70438. Date of Electronic Publication: 2026 Jul 22 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101740619 Publication Model: eCollection Cited Medium: Internet ISSN: 2572-9241 (Electronic) Linking ISSN: 25729241 NLM ISO Abbreviation: Hemasphere Subsets: PubMed not MEDLINE

A novel CRLF2-targeted antibody-drug conjugate exhibits potent anti-leukemic activity against Ph-like acute lymphoblastic leukemia.

Authors: Mohamed SMA Schofield P Evans K et al.

Source: Leukemia [Leukemia] 2026 Jul; Vol. 40 (7), pp. 1569-1573. Date of Electronic Publication: 2026 May 05.

Publication Type: Letter

Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE; In Process

BCL-2 and MCL1 co-inhibition enhances glucocorticoid therapy in preclinical models of infant KMT2A-rearranged acute lymphoblastic leukaemia.

Authors: Karsa M Karsa A Spurling D et al.

Source: British journal of haematology [Br J Haematol] 2026 Jun 05. Date of Electronic Publication: 2026 Jun 05.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE

The myeloid cell leukaemia-1 inhibitor MIK665 is a potent therapy in preclinical models of paediatric acute myeloid leukaemia.

Authors: Connerty P Colgan JN El-Najjar F et al.

Source: British journal of haematology [Br J Haematol] 2026 Jun 04. Date of Electronic Publication: 2026 Jun 04.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE

Polyamine depletion limits progression of acute leukaemia.

Authors: Gao W Karsa M Xiao L et al.

Source: International journal of cancer [Int J Cancer] 2025 Jun 15; Vol. 156 (12), pp. 2360-2376. Date of Electronic Publication: 2025 Feb 22.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE

Comprehensive Multiplatform Tyrosine Kinase Profiling Reveals Novel Actionable FGFR Aberrations across Sarcomas Affecting the Young.

Authors: Fordham AM Brown LM Mayoh C et al.

Source: Molecular cancer therapeutics [Mol Cancer Ther] 2026 Apr 27, pp. OF1-OF18. Date of Electronic Publication: 2026 Apr 27.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

Comprehensive multi-platform tyrosine kinase profiling reveals novel actionable FGFR aberrations across sarcomas affecting the young.

Authors: Fordham AM Brown LM Mayoh C et al.

Source: Molecular cancer therapeutics [Mol Cancer Ther] 2026 Mar 19. Date of Electronic Publication: 2026 Mar 19.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

Immune-deficient MISTRG mice support expansion of leukaemia-initiating cells in xenograft models of paediatric acute myeloid leukaemia.

Authors: Connerty P Xie J El-Najjar F et al.

Source: British journal of haematology [Br J Haematol] 2025 Apr; Vol. 206 (4), pp. 1092-1096. Date of Electronic Publication: 2025 Feb 21.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE

Inhibition of the NLRP3 inflammasome using MCC950 reduces vincristine-induced adverse effects in an acute lymphoblastic leukemia patient-derived xenograft model.

Authors: Starobova H McCalmont H Shatunova S et al.

Source: HemaSphere [Hemasphere] 2025 Mar 18; Vol. 9 (3), pp. e70092. Date of Electronic Publication: 2025 Mar 18 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101740619 Publication Model: eCollection Cited Medium: Internet ISSN: 2572-9241 (Electronic) Linking ISSN: 25729241 NLM ISO Abbreviation: Hemasphere Subsets: PubMed not MEDLINE

Targeting osteoclasts for treatment of high-risk B-cell acute lymphoblastic leukemia.

Authors: Kotecha RS Trinder SM Hughes AM et al.

Source: Blood cancer journal [Blood Cancer J] 2025 Feb 27; Vol. 15 (1), pp. 25. Date of Electronic Publication: 2025 Feb 27.

Publication Type: Letter

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101568469 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-5385 (Electronic) Linking ISSN: 20445385 NLM ISO Abbreviation: Blood Cancer J Subsets: MEDLINE; In Process

The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia.

Authors: Toscan CE McCalmont H Ashoorzadeh A et al.

Source: Blood cancer journal [Blood Cancer J] 2024 Nov 06; Vol. 14 (1), pp. 192. Date of Electronic Publication: 2024 Nov 06.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101568469 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-5385 (Electronic) Linking ISSN: 20445385 NLM ISO Abbreviation: Blood Cancer J Subsets: MEDLINE

TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells.

Authors: Truong P Shen S Joshi S et al.

Source: Nature communications [Nat Commun] 2024 Aug 28; Vol. 15 (1), pp. 7360. Date of Electronic Publication: 2024 Aug 28.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

FDA-approved disulfiram as a novel treatment for aggressive leukemia.

Authors: Karsa M Xiao L Ronca E et al.

Source: Journal of molecular medicine (Berlin, Germany) [J Mol Med (Berl)] 2024 Apr; Vol. 102 (4), pp. 507-519. Date of Electronic Publication: 2024 Feb 13.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 9504370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1440 (Electronic) Linking ISSN: 09462716 NLM ISO Abbreviation: J Mol Med (Berl) Subsets: MEDLINE

The tip of the iceberg-The roles of long noncoding RNAs in acute myeloid leukemia.

Authors: Connerty P Lock RB

Source: Wiley interdisciplinary reviews. RNA [Wiley Interdiscip Rev RNA] 2023 Nov-Dec; Vol. 14 (6), pp. e1796. Date of Electronic Publication: 2023 Jun 02.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101536955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-7012 (Electronic) Linking ISSN: 17577004 NLM ISO Abbreviation: Wiley Interdiscip Rev RNA Subsets: MEDLINE

In vivo activity of the dual PI3Kδ and PI3Kγ inhibitor duvelisib against pediatric acute lymphoblastic leukemia xenografts.

Authors: Randall J Evans K Watts B et al.

Source: Pediatric blood & cancer [Pediatr Blood Cancer] 2023 Aug; Vol. 70 (8), pp. e30398. Date of Electronic Publication: 2023 May 04.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: John Wiley Country of Publication: United States NLM ID: 101186624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-5017 (Electronic) Linking ISSN: 15455009 NLM ISO Abbreviation: Pediatr Blood Cancer Subsets: MEDLINE

Targeting LMO2-induced autocrine FLT3 signaling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia.

Authors: Tremblay CS Saw J Yan F et al.

Source: Leukemia [Leukemia] 2025 Mar; Vol. 39 (3), pp. 577-589. Date of Electronic Publication: 2025 Jan 23.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE

Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia.

Authors: Moles E Howard CB Huda P et al.

Source: Science translational medicine [Sci Transl Med] 2023 May 17; Vol. 15 (696), pp. eabm1262. Date of Electronic Publication: 2023 May 17.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies.

Authors: Germon ZP Sillar JR Mannan A et al.

Source: Science signaling [Sci Signal] 2023 Mar 28; Vol. 16 (778), pp. eabp9586. Date of Electronic Publication: 2023 Mar 28.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE

The CD123 antibody-drug conjugate pivekimab sunirine exerts profound activity in preclinical models of pediatric acute lymphoblastic leukemia.

Authors: Watts B Smith CM Evans K et al.

Source: HemaSphere [Hemasphere] 2025 Jan 17; Vol. 9 (1), pp. e70063. Date of Electronic Publication: 2025 Jan 17 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101740619 Publication Model: eCollection Cited Medium: Internet ISSN: 2572-9241 (Electronic) Linking ISSN: 25729241 NLM ISO Abbreviation: Hemasphere Subsets: PubMed not MEDLINE