Search Results - "Loria, Paula M."

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Hit Triage and Validation in Phenotypic Screening: Considerations and Strategies.

Authors: Vincent, Fabien Loria, Paula M. Weston, Andrea D. et al.

Source: Cell Chemical Biology. Nov2020, Vol. 27 Issue 11, p1332-1346. 15p.

Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.

Authors: McClure, Kim F. Piotrowski, David W. Petersen, Donna et al.

Source: Angewandte Chemie International Edition; 12/18/2017, Vol. 56 Issue 51, p16218-16222, 5p

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Modulation of αCaMKII signaling by rapid ERα action

Authors: O'Neill, Erin E. Blewett, Alexis R. Loria, Paula M. et al.

Source: Brain Research. Jul2008, Vol. 1222, p1-17. 17p.

Discovery of N-(piperidin-3-yl)-N-(pyridin-2-yl)piperidine/piperazine-1-carboxamides as small molecule inhibitors of PCSK9.

Authors: Londregan, Allyn T. Aspnes, Gary Limberakis, Chris et al.

Source: Bioorganic & Medicinal Chemistry Letters. Dec2018, Vol. 28 Issue 23/24, p3685-3688. 4p.

Identification of Morpholino-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-ones as Nonsteroidal Mineralocorticoid Antagonists.

Authors: Piotrowski, David W. Kentaro Futatsugi Casimiro-Garcia, Agustin et al.

Source: Journal of Medicinal Chemistry. 2/8/2018, Vol. 61 Issue 3, p1086-1097. 12p.

Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).

Authors: Gopalsamy, Ariamala Narayanan, Arjun Shenping Liu et al.

Source: Journal of Medicinal Chemistry. 4/13/2017, Vol. 60 Issue 7, p3094-3108. 15p.

Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling.

Authors: Plisson, Fabien Hill, Timothy A. Mitchell, Justin M. et al.

Source: European Journal of Medicinal Chemistry. Feb2017, Vol. 127, p703-714. 12p.

A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation.

Authors: Petersen, Donna N. Hawkins, Julie Ruangsiriluk, Wanida et al.

Source: Cell Chemical Biology. Nov2016, Vol. 23 Issue 11, p1362-1371. 10p.

Optimization of amide-based EP3 receptor antagonists.

Authors: Lee, Esther C.Y. Futatsugi, Kentaro Arcari, Joel T. et al.

Source: Bioorganic & Medicinal Chemistry Letters. Jun2016, Vol. 26 Issue 11, p2670-2675. 6p.

Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists.

Authors: Swedberg, Joakim E. Schroeder, Christina I. Mitchell, Justin M. et al.

Source: European Journal of Medicinal Chemistry. Oct2015, Vol. 103, p175-184. 10p.

Identification of (R)-6-(1-(4-Cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic Acid, a HighlyPotent and Selective Nonsteroidal Mineralocorticoid Receptor Antagonist.

Authors: Casimiro-Garcia, Agustin Piotrowski, David W. Ambler, Catherine et al.

Source: Journal of Medicinal Chemistry. May2014, Vol. 57 Issue 10, p4273-4288. 16p.

Design and synthesis of aryl sulfonamide-based nonsteroidal mineralocorticoid receptor antagonists.

Authors: Futatsugi, Kentaro Piotrowski, David W. Casimiro-Garcia, Agustin et al.

Source: Bioorganic & Medicinal Chemistry Letters. Dec2013, Vol. 23 Issue 23, p6239-6242. 4p.