Search Results - "Loria PM"

Myostatin inhibition enhances the effects of exercise on performance and metabolic outcomes in aged mice.

Authors: LeBrasseur NK Schelhorn TM Bernardo BL et al.

Source: Journals of Gerontology Series A: Biological Sciences & Medical Sciences. Sep2009, Vol. 64A Issue 9, p940-948. 9p.

URL: 53297693

Iron status and root cell morphology of Arabidopsis thaliana as modified by a bacterial ferri-siderophore.

Authors: Avoscan L Lurthy T Lherminier J et al.

Source: Physiologia plantarum [Physiol Plant] 2024 Jan-Feb; Vol. 176 (1), pp. e14223.

Publication Type: Journal Article

Journal Info: Publisher: Scandinavian Society For Plant Physiology Country of Publication: Denmark NLM ID: 1256322 Publication Model: Print Cited Medium: Internet ISSN: 1399-3054 (Electronic) Linking ISSN: 00319317 NLM ISO Abbreviation: Physiol Plant Subsets: MEDLINE

Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.

Authors: Londregan AT Aitmakhanova K Bennett J et al.

Source: Journal of medicinal chemistry [J Med Chem] 2023 Jan 12; Vol. 66 (1), pp. 460-472. Date of Electronic Publication: 2022 Dec 23.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.

Authors: Futatsugi K Cabral S Kung DW et al.

Source: Journal of medicinal chemistry [J Med Chem] 2022 Nov 24; Vol. 65 (22), pp. 15000-15013. Date of Electronic Publication: 2022 Nov 02.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.

Authors: Lintner NG McClure KF Petersen D et al.

Source: PLoS biology [PLoS Biol] 2018 Apr 17; Vol. 16 (4), pp. e1002628. Date of Electronic Publication: 2018 Apr 17 (Print Publication: 2018).

Publication Type: Journal Article; Published Erratum

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: PubMed not MEDLINE

Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate.

Authors: McCorvie TJ Loria PM Tu M et al.

Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2022 Jul; Vol. 29 (7), pp. 628-638. Date of Electronic Publication: 2022 Jul 14.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.

Authors: Griffith DA Edmonds DJ Fortin JP et al.

Source: Journal of medicinal chemistry [J Med Chem] 2022 Jun 23; Vol. 65 (12), pp. 8208-8226. Date of Electronic Publication: 2022 Jun 01.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Modulation of SF3B1 in the pre-mRNA spliceosome induces a RIG-I-dependent type I IFN response.

Authors: Chang AY Zhou YJ Iyengar S et al.

Source: The Journal of biological chemistry [J Biol Chem] 2021 Nov; Vol. 297 (5), pp. 101277. Date of Electronic Publication: 2021 Oct 05.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.

Authors: Lintner NG McClure KF Petersen D et al.

Source: PLoS biology [PLoS Biol] 2017 Mar 21; Vol. 15 (3), pp. e2001882. Date of Electronic Publication: 2017 Mar 21 (Print Publication: 2017).

Publication Type: Journal Article; Validation Study

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

Pharmacological characterization of the first in class clinical candidate PF-05190457: a selective ghrelin receptor competitive antagonist with inverse agonism that increases vagal afferent firing and glucose-dependent insulin secretion ex vivo.

Authors: Kong J Chuddy J Stock IA et al.

Source: British journal of pharmacology [Br J Pharmacol] 2016 May; Vol. 173 (9), pp. 1452-64. Date of Electronic Publication: 2016 Mar 17.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Hit Triage and Validation in Phenotypic Screening: Considerations and Strategies.

Authors: Vincent F Loria PM Weston AD et al.

Source: Cell chemical biology [Cell Chem Biol] 2020 Nov 19; Vol. 27 (11), pp. 1332-1346. Date of Electronic Publication: 2020 Sep 03.

Publication Type: Journal Article; Review

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

Discovery of Diphenylacetamides as CXCR7 Inhibitors with Novel β-Arrestin Antagonist Activity.

Authors: Menhaji-Klotz E Ward J Brown JA et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 May 14; Vol. 11 (6), pp. 1330-1334. Date of Electronic Publication: 2020 May 14 (Print Publication: 2020).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

A genetic screen for neurite outgrowth mutants in Caenorhabditis elegans reveals a new function for the F-box ubiquitin ligase component LIN-23.

Authors: Mehta N Loria PM Hobert O

Source: Genetics [Genetics] 2004 Mar; Vol. 166 (3), pp. 1253-67.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0374636 Publication Model: Print Cited Medium: Print ISSN: 0016-6731 (Print) Linking ISSN: 00166731 NLM ISO Abbreviation: Genetics Subsets: MEDLINE

Discovery of N-(piperidin-3-yl)-N-(pyridin-2-yl)piperidine/piperazine-1-carboxamides as small molecule inhibitors of PCSK9.

Authors: Londregan AT Aspnes G Limberakis C et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Dec 15; Vol. 28 (23-24), pp. 3685-3688. Date of Electronic Publication: 2018 Oct 22.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1).

Authors: Filipski KJ Sammons MF Bhattacharya SK et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Apr 12; Vol. 9 (5), pp. 440-445. Date of Electronic Publication: 2018 Apr 12 (Print Publication: 2018).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Identification of Morpholino-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-ones as Nonsteroidal Mineralocorticoid Antagonists.

Authors: Piotrowski DW Futatsugi K Casimiro-Garcia A et al.

Source: Journal of medicinal chemistry [J Med Chem] 2018 Feb 08; Vol. 61 (3), pp. 1086-1097. Date of Electronic Publication: 2018 Jan 23.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.

Authors: McClure KF Piotrowski DW Petersen D et al.

Source: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 Dec 18; Vol. 56 (51), pp. 16218-16222. Date of Electronic Publication: 2017 Nov 24.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).

Authors: Gopalsamy A Narayanan A Liu S et al.

Source: Journal of medicinal chemistry [J Med Chem] 2017 Apr 13; Vol. 60 (7), pp. 3094-3108. Date of Electronic Publication: 2017 Mar 16.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling.

Authors: Plisson F Hill TA Mitchell JM et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2017 Feb 15; Vol. 127, pp. 703-714. Date of Electronic Publication: 2016 Oct 21.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation.

Authors: Petersen DN Hawkins J Ruangsiriluk W et al.

Source: Cell chemical biology [Cell Chem Biol] 2016 Nov 17; Vol. 23 (11), pp. 1362-1371. Date of Electronic Publication: 2016 Oct 13.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE