Search Results - "Marsham PR"

Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity.

Authors: Block MH Boyer S Brailsford W et al.

Source: Journal of medicinal chemistry [J Med Chem] 2002 Aug 01; Vol. 45 (16), pp. 3509-23.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors.

Authors: Marsham PR Wardleworth JM Boyle FT et al.

Source: Journal of medicinal chemistry [J Med Chem] 1999 Sep 23; Vol. 42 (19), pp. 3809-20.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Quinazoline antifolates thymidylate synthase inhibitors: lipophilic analogues with modification to the C2-methyl substituent.

Authors: Hennequin LF Boyle FT Wardleworth JM et al.

Source: Journal of medicinal chemistry [J Med Chem] 1996 Feb 02; Vol. 39 (3), pp. 695-704.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series.

Authors: Marsham PR Jackman AL Barker AJ et al.

Source: Journal of medicinal chemistry [J Med Chem] 1995 Mar 17; Vol. 38 (6), pp. 994-1004.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

The measurement of polyglutamate metabolites of the thymidylate synthase inhibitor, ICI D1694, in mouse and human cultured cells.

Authors: Gibson W Bisset GM Marsham PR et al.

Source: Biochemical pharmacology [Biochem Pharmacol] 1993 Feb 24; Vol. 45 (4), pp. 863-9.

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print Cited Medium: Print ISSN: 0006-2952 (Print) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues.

Authors: Thornton TJ Jackman AL Marsham PR et al.

Source: Journal of medicinal chemistry [J Med Chem] 1992 Jun 12; Vol. 35 (12), pp. 2321-7.

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series.

Authors: Marsham PR Jackman AL Hayter AJ et al.

Source: Journal of medicinal chemistry [J Med Chem] 1991 Jul; Vol. 34 (7), pp. 2209-18.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications.

Authors: Marsham PR Hughes LR Jackman AL et al.

Source: Journal of medicinal chemistry [J Med Chem] 1991 May; Vol. 34 (5), pp. 1594-605.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Thymidylate synthase inhibitors: the in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates.

Authors: Jackman AL Marsham PR Moran RG et al.

Source: Advances in enzyme regulation [Adv Enzyme Regul] 1991; Vol. 31, pp. 13-27.

Publication Type: Journal Article; Review

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0044263 Publication Model: Print Cited Medium: Print ISSN: 0065-2571 (Print) Linking ISSN: 00652571 NLM ISO Abbreviation: Adv Enzyme Regul Subsets: MEDLINE

Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position.

Authors: Hughes LR Jackman AL Oldfield J et al.

Source: Journal of medicinal chemistry [J Med Chem] 1990 Nov; Vol. 33 (11), pp. 3060-7.

Publication Type: Comparative Study; Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series.

Authors: Marsham PR Jackman AL Oldfield J et al.

Source: Journal of medicinal chemistry [J Med Chem] 1990 Nov; Vol. 33 (11), pp. 3072-8.

Publication Type: Comparative Study; Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position.

Authors: Jackman AL Marsham PR Thornton TJ et al.

Source: Journal of medicinal chemistry [J Med Chem] 1990 Nov; Vol. 33 (11), pp. 3067-71.

Publication Type: Comparative Study; Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Inhibitors of prostaglandin biosynthesis: a bicyclo-(2.2.1)-heptene analogue of '2' series prostaglandins and related derivatives.

Authors: Leeney TJ Marsham PR Ritchie GA et al.

Source: Prostaglandins [Prostaglandins] 1976 Jun; Vol. 11 (6), pp. 953-60.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 0320271 Publication Model: Print Cited Medium: Print ISSN: 0090-6980 (Print) Linking ISSN: 00906980 NLM ISO Abbreviation: Prostaglandins Subsets: MEDLINE

Quinazoline antifolate thymidylate synthase inhibitors: nitrogen, oxygen, sulfur, and chlorine substituents in the C2 position.

Authors: Marsham PR Chambers P Hayter AJ et al.

Source: Journal of medicinal chemistry [J Med Chem] 1989 Mar; Vol. 32 (3), pp. 569-75.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE