Search Results - "McCombie SW"

Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors.

Authors: Gilbert EJ Zhou G Wong MK et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Jan 15; Vol. 20 (2), pp. 608-11. Date of Electronic Publication: 2009 Nov 22.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Optimization of triaryl bis-sulfones as cannabinoid-2 receptor ligands.

Authors: Lavey BJ Kozlowski JA Shankar BB et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Jul 01; Vol. 17 (13), pp. 3760-4. Date of Electronic Publication: 2007 Apr 10.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Interaction of small molecule inhibitors of HIV-1 entry with CCR5.

Authors: Seibert C Ying W Gavrilov S et al.

Source: Virology [Virology] 2006 May 25; Vol. 349 (1), pp. 41-54. Date of Electronic Publication: 2006 Feb 21.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0110674 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0042-6822 (Print) Linking ISSN: 00426822 NLM ISO Abbreviation: Virology Subsets: MEDLINE

Inhibition of the development of collagen-induced arthritis in rhesus monkeys by a small molecular weight antagonist of CCR5.

Authors: Vierboom MP Zavodny PJ Chou CC et al.

Source: Arthritis and rheumatism [Arthritis Rheum] 2005 Feb; Vol. 52 (2), pp. 627-36.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 0370605 Publication Model: Print Cited Medium: Print ISSN: 0004-3591 (Print) Linking ISSN: 00043591 NLM ISO Abbreviation: Arthritis Rheum Subsets: MEDLINE

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist.

Authors: Tagat JR McCombie SW Nazareno D et al.

Source: Journal of medicinal chemistry [J Med Chem] 2004 May 06; Vol. 47 (10), pp. 2405-8.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity.

Authors: Clader JW Billard W Binch H 3rd et al.

Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2004 Jan 15; Vol. 12 (2), pp. 319-26.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print Cited Medium: Print ISSN: 0968-0896 (Print) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. III: synthesis, antiviral and pharmacokinetic profiles of symmetrical heteroaryl carboxamides.

Authors: McCombie SW Tagat JR Vice SF et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2003 Feb 10; Vol. 13 (3), pp. 567-71.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification.

Authors: Boyle CD Vice SF Campion J et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2002 Dec 02; Vol. 12 (23), pp. 3479-82.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands.

Authors: Kozlowski JA Zhou G Tagat JR et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2002 Mar 11; Vol. 12 (5), pp. 791-4.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Synthesis and structure-activity relationships of M(2)-selective muscarinic receptor ligands in the 1-[4-(4-arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family.

Authors: McCombie SW Lin SI Tagat JR et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2002 Mar 11; Vol. 12 (5), pp. 795-8.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Synthesis of mono- and difluoronaphthoic acids.

Authors: Tagat JR McCombie SW Nazareno DV et al.

Source: The Journal of organic chemistry [J Org Chem] 2002 Feb 22; Vol. 67 (4), pp. 1171-7.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print Cited Medium: Print ISSN: 0022-3263 (Print) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: PubMed not MEDLINE

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist.

Authors: Tagat JR Steensma RW McCombie SW et al.

Source: Journal of medicinal chemistry [J Med Chem] 2001 Oct 11; Vol. 44 (21), pp. 3343-6.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution.

Authors: Boyle CD Chackalamannil S Clader JW et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2001 Sep 03; Vol. 11 (17), pp. 2311-4.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element.

Authors: Tagat JR McCombie SW Steensma RW et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2001 Aug 20; Vol. 11 (16), pp. 2143-6.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

SCH 47112, a novel staurosporine derivative, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and epidermal hyperplasia in hairless mouse skin.

Authors: Reynolds NJ McCombie SW Shankar BB et al.

Source: Archives of dermatological research [Arch Dermatol Res] 1997 Aug; Vol. 289 (9), pp. 540-6.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8000462 Publication Model: Print Cited Medium: Print ISSN: 0340-3696 (Print) Linking ISSN: 03403696 NLM ISO Abbreviation: Arch Dermatol Res Subsets: MEDLINE

Synthesis and in vitro activity of the penem antibiotics.

Authors: McCombie SW Ganguly AK

Source: Medicinal research reviews [Med Res Rev] 1988 Jul-Sep; Vol. 8 (3), pp. 393-440.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 8103150 Publication Model: Print Cited Medium: Print ISSN: 0198-6325 (Print) Linking ISSN: 01986325 NLM ISO Abbreviation: Med Res Rev Subsets: MEDLINE

Some recent advances in the chemistry of antibiotics of the gentamicin series.

Authors: Daniels PJ Cooper AB McCombie SW et al.

Source: The Japanese journal of antibiotics [Jpn J Antibiot] 1979 Dec; Vol. 32 Suppl, pp. S195-204.

Publication Type: Journal Article; Review

Journal Info: Publisher: Japan Antibiotics Research Assn Country of Publication: Japan NLM ID: 0154402 Publication Model: Print Cited Medium: Print ISSN: 0368-2781 (Print) Linking ISSN: 03682781 NLM ISO Abbreviation: Jpn J Antibiot Subsets: MEDLINE

Pyrroles and related compounds. 30. Cyclisation of porphyrin beta-keto-esters to phaeoporphyrins.

Authors: Kenner GW McCombie SW Smith KM

Source: Journal of the Chemical Society. Perkin transactions 1 [J Chem Soc Perkin 1] 1974; Vol. 4, pp. 527-30.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 7505598 Publication Model: Print Cited Medium: Print ISSN: 0300-922X (Print) Linking ISSN: 0300922X NLM ISO Abbreviation: J Chem Soc Perkin 1 Subsets: MEDLINE

Pyrroles and related compounds. 29. Vinylporphyrin beta-keto-esters.

Authors: Cox MT Jackson AH Kenner GW et al.

Source: Journal of the Chemical Society. Perkin transactions 1 [J Chem Soc Perkin 1] 1974; Vol. 4, pp. 516-27.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 7505598 Publication Model: Print Cited Medium: Print ISSN: 0300-922X (Print) Linking ISSN: 0300922X NLM ISO Abbreviation: J Chem Soc Perkin 1 Subsets: MEDLINE

Pyrroles and related compounds. XXIV. Separation and oxidative degradation of chlorophyll derivatives.

Authors: Kenner GW McCombie SW Smith KM

Source: Journal of the Chemical Society. Perkin transactions 1 [J Chem Soc Perkin 1] 1973; Vol. 21, pp. 2517-23.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 7505598 Publication Model: Print Cited Medium: Print ISSN: 0300-922X (Print) Linking ISSN: 0300922X NLM ISO Abbreviation: J Chem Soc Perkin 1 Subsets: MEDLINE