Search Results - "Mehellou Y"

Oxidative Stress-Responsive 1 Kinase Catalytic Activity Promotes Triple Negative Breast Cancer Oncogenic Potential.

Authors: Fdel AM Waters L Sharma I et al.

Source: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2025 Feb 27; Vol. 8 (3), pp. 726-735. Date of Electronic Publication: 2025 Feb 27 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101721411 Publication Model: eCollection Cited Medium: Internet ISSN: 2575-9108 (Electronic) Linking ISSN: 25759108 NLM ISO Abbreviation: ACS Pharmacol Transl Sci Subsets: PubMed not MEDLINE

Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains.

Authors: Elvers KT Lipka-Lloyd M Trueman RC et al.

Source: Chembiochem : a European journal of chemical biology [Chembiochem] 2022 Jan 05; Vol. 23 (1), pp. e202100441. Date of Electronic Publication: 2021 Nov 24.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

Generation of Stable Isopentenyl Monophosphate Aryloxy Triester Phosphoramidates as Activators of Vγ9Vδ2 T Cells.

Authors: Xu Q Taher TE Ashby E et al.

Source: ChemMedChem [ChemMedChem] 2021 Aug 05; Vol. 16 (15), pp. 2375-2380. Date of Electronic Publication: 2021 May 19.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

Phosphonodiamidate prodrugs of phosphoantigens (ProPAgens) exhibit potent Vγ9/Vδ2 T cell activation and eradication of cancer cells.

Authors: Xu Q Sharif M James E et al.

Source: RSC medicinal chemistry [RSC Med Chem] 2024 Jun 03; Vol. 15 (7), pp. 2462-2473. Date of Electronic Publication: 2024 Jun 03 (Print Publication: 2024).

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem Subsets: PubMed not MEDLINE

Aryloxy Triester Phosphoramidates as Phosphoserine Prodrugs: A Proof of Concept Study.

Authors: Miccoli A Dhiani BA Thornton PJ et al.

Source: ChemMedChem [ChemMedChem] 2020 Apr 20; Vol. 15 (8), pp. 671-674. Date of Electronic Publication: 2020 Mar 26.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner.

Authors: Dhiani BA Mehellou Y

Source: Chembiochem : a European journal of chemical biology [Chembiochem] 2020 Mar 02; Vol. 21 (5), pp. 638-643. Date of Electronic Publication: 2019 Oct 15.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

Parkinson's Disease: Are PINK1 Activators Inching Closer to the Clinic?

Authors: Mehellou Y; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3NB, U.K.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Jun 15; Vol. 14 (7), pp. 870-874. Date of Electronic Publication: 2023 Jun 15 (Print Publication: 2023).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

PINK1-Dependent Mitophagy Inhibits Elevated Ubiquitin Phosphorylation Caused by Mitochondrial Damage.

Authors: Lambourne OA Bell S Wilhelm LP et al.

Source: Journal of medicinal chemistry [J Med Chem] 2023 Jun 08; Vol. 66 (11), pp. 7645-7656. Date of Electronic Publication: 2023 May 29.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Chemical Strategies for Activating PINK1, a Protein Kinase Mutated in Parkinson's Disease.

Authors: Lambourne OA Mehellou Y

Source: Chembiochem : a European journal of chemical biology [Chembiochem] 2018 Dec 04; Vol. 19 (23), pp. 2433-2437. Date of Electronic Publication: 2018 Nov 07.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

The Photosensitising Clinical Agent Verteporfin Is an Inhibitor of SPAK and OSR1 Kinases.

Authors: AlAmri MA Kadri H Alderwick LJ et al.

Source: Chembiochem : a European journal of chemical biology [Chembiochem] 2018 Oct 04; Vol. 19 (19), pp. 2072-2080. Date of Electronic Publication: 2018 Aug 22.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

Niclosamide, a Drug with Many (Re)purposes.

Authors: Kadri H Lambourne OA Mehellou Y

Source: ChemMedChem [ChemMedChem] 2018 Jun 06; Vol. 13 (11), pp. 1088-1091. Date of Electronic Publication: 2018 May 08.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1.

Authors: Barini E Miccoli A Tinarelli F et al.

Source: Chembiochem : a European journal of chemical biology [Chembiochem] 2018 Mar 02; Vol. 19 (5), pp. 425-429. Date of Electronic Publication: 2018 Jan 24.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

WNK Signaling Inhibitors as Potential Antihypertensive Drugs.

Authors: AlAmri MA Kadri H Dhiani BA et al.

Source: ChemMedChem [ChemMedChem] 2017 Oct 20; Vol. 12 (20), pp. 1677-1686. Date of Electronic Publication: 2017 Sep 26.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

Aryloxy Pivaloyloxymethyl Prodrugs as Nucleoside Monophosphate Prodrugs.

Authors: Alanazi AS Miccoli A Mehellou Y

Source: Journal of medicinal chemistry [J Med Chem] 2021 Nov 25; Vol. 64 (22), pp. 16703-16710. Date of Electronic Publication: 2021 Nov 04.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C-terminal Domains.

Authors: AlAmri MA Kadri H Alderwick LJ et al.

Source: ChemMedChem [ChemMedChem] 2017 May 09; Vol. 12 (9), pp. 639-645. Date of Electronic Publication: 2017 Apr 12.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

Towards the Development of Small-Molecule MO25 Binders as Potential Indirect SPAK/OSR1 Kinase Inhibitors.

Authors: Kadri H Alamri MA Navratilova IH et al.

Source: Chembiochem : a European journal of chemical biology [Chembiochem] 2017 Mar 02; Vol. 18 (5), pp. 460-465. Date of Electronic Publication: 2017 Jan 30.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

The ProTides Boom.

Authors: Mehellou Y; School of Pharmacy, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, B15 2TT, UK. y.mehellou@bham.ac.uk.

Source: ChemMedChem [ChemMedChem] 2016 Jun 06; Vol. 11 (11), pp. 1114-6. Date of Electronic Publication: 2016 May 09.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

A two-pronged attack on antibiotic-resistant microbes.

Authors: Mehellou Y Willcox BE

Source: Nature [Nature] 2021 Jan; Vol. 589 (7843), pp. 517-518.

Publication Type: News; Comment

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

SPAK and OSR1 kinases bind and phosphorylate the β2-Adrenergic receptor.

Authors: Elzwawi A Grafton G Barnes NM et al.

Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Oct 29; Vol. 532 (1), pp. 88-93. Date of Electronic Publication: 2020 Aug 20.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

Aryloxy Diester Phosphonamidate Prodrugs of Phosphoantigens (ProPAgens) as Potent Activators of Vγ9/Vδ2 T-Cell Immune Responses.

Authors: Kadri H Taher TE Xu Q et al.

Source: Journal of medicinal chemistry [J Med Chem] 2020 Oct 08; Vol. 63 (19), pp. 11258-11270. Date of Electronic Publication: 2020 Sep 29.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE